Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Emily J Poulin"'
Autor:
Jesse Lyons, Phaedra C Ghazi, Alina Starchenko, Alessio Tovaglieri, Katherine R Baldwin, Emily J Poulin, Jessica J Gierut, Casie Genetti, Vijay Yajnik, David T Breault, Douglas A Lauffenburger, Kevin M Haigis
Publikováno v:
PLoS Biology, Vol 16, Iss 3, p e2002417 (2018)
Inflammatory bowel disease (IBD) is a chronic condition driven by loss of homeostasis between the mucosal immune system, the commensal gut microbiota, and the intestinal epithelium. Our goal is to understand how these components of the intestinal eco
Externí odkaz:
https://doaj.org/article/47ef114201964675b32fd68e61204548
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Proteomics data from human cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2426b866d556530901ce4ab6f469c7a7
https://doi.org/10.1158/2159-8290.22532587
https://doi.org/10.1158/2159-8290.22532587
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Supplementary Figures S1-S18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea23cd43399e8b35ccc18f1cea0e40ed
https://doi.org/10.1158/2159-8290.22532605
https://doi.org/10.1158/2159-8290.22532605
Autor:
Kevin M. Haigis, Kenneth D. Westover, Douglas A. Lauffenburger, Steven P. Gygi, Benjamin S. Braun, Pedro A. Perez-Mancera, John R. Engen, Yina Li, Jessica J. Gierut, Lana Bogdanova, Roxana E. Iacob, Thomas E. Wales, Sudershan Gondi, Phaedra C. Ghazi, Rebecca A. DeStefanis, Christian W. Johnson, Brian A. Joughin, Douglas K. Brubaker, Jonathan A. Nowak, Joshua Cook, Wei Yan, Carolina Morales, Tannie Q. Huang, Joao A. Paulo, Samantha Dale Strasser, Yi-Jang Lin, Jia Lu, Asim K. Bera, Emily J. Poulin
Data collection and refinement statistics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f8366377fb78585b44b56e2021cd08
https://doi.org/10.1158/2159-8290.22532602
https://doi.org/10.1158/2159-8290.22532602
Autor:
Qin Zhang, Dennis K. Jeppesen, James N. Higginbotham, Michelle Demory Beckler, Emily J. Poulin, Alex J. Walsh, Melissa C. Skala, Eliot T. McKinley, H. Charles Manning, Matthew R. Hight, Michael L. Schulte, Kimberly R. Watt, G. Daniel Ayers, Melissa M. Wolf, Gabriela Andrejeva, Jeffrey C. Rathmell, Jeffrey L. Franklin, Robert J. Coffey
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 627-629.e6 (2018)
Externí odkaz:
https://doaj.org/article/2f29401d5351432ba699592b4cc25b76
Using a new Lrig1 reporter mouse to assess differences between two Lrig1 antibodies in the intestine
Publikováno v:
Stem Cell Research, Vol 13, Iss 3, Pp 422-430 (2014)
Lrig1 is an intestinal stem cell marker important for epithelial homeostasis. However, the position of the Lrig1+ population in the intestinal crypt has been debated, largely due to discrepant staining patterns using two Lrig1 antibodies. Here, we se
Externí odkaz:
https://doaj.org/article/f517137d04014df59e5b9ce0cbb56ddc
Autor:
Jinhua Wang, Senthil Muthaswamy, Kevin M. Haigis, Rita Sulahian, Kenneth D. Westover, Emily J. Poulin, Ryoma Ohi, Sergio Espinosa, Shuning He, Taebo Sim, Lianbo Li, Miljan Kuljanin, Nathanael S. Gray, Yan Liu, Nam Doo Kim, Joseph D. Mancias, Ling Huang, Brian M. Wolpin, Charles Y. Lin, Andrew J. Aguirre, Srivatsan Raghavan, Nora Diéguez-Martínez, Radha L. Kalekar, Jost Vrabic Koren, Zeng Zhiyang, Fleur M. Ferguson, James D Vasta, Behnam Nabet, William C. Hahn, Raymond W.S. Ng, Cesear Corona, Wayne Harshbarger, Alan L. Leggett, Matthew B. Robers, A. Thomas Look, Jose M. Lizcano, Annan Yang
Publikováno v:
Nature chemical biology
Doublecortin like kinase 1 (DCLK1) is an understudied kinase that is upregulated in a wide range of cancers, including pancreatic ductal adenocarcinoma (PDAC). However, little is known about its potential as a therapeutic target. We used chemoproteom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0e3c79de5a15f9fac24f15a81dc963
https://doi.org/10.1038/s41589-020-0506-0
https://doi.org/10.1038/s41589-020-0506-0
Autor:
Christian W. Johnson, Pedro A. Perez-Mancera, Steven P. Gygi, Joshua Cook, Benjamin S. Braun, Jessica J. Gierut, Samantha Dale Strasser, Douglas K. Brubaker, Jonathan A. Nowak, Brian A. Joughin, Rebecca A. Destefanis, Kenneth D. Westover, John R. Engen, Lana Bogdanova, Kevin M. Haigis, Carolina Morales, Emily J. Poulin, Jia Lu, Yi Jang Lin, Phaedra C. Ghazi, Asim K. Bera, Joao A. Paulo, Yina Li, Thomas E. Wales, Wei Yan, Sudershan R. Gondi, Roxana E. Iacob, Tannie Q. Huang, Douglas A. Lauffenburger
Publikováno v:
Cancer Discov
CANCER DISCOVERY
PMC
CANCER DISCOVERY
PMC
KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS proteins. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f87a5e50f6b926f0042b2b594d2960
https://europepmc.org/articles/PMC6548671/
https://europepmc.org/articles/PMC6548671/
Autor:
Kevin M. Haigis, Emily J. Poulin
Publikováno v:
Genes & Development. 31:333-335
KRAS is the most frequently mutated oncogene in human cancer and plays a central, although poorly understood, role in colorectal cancer (CRC) progression. In this issue of Genes & Development, Boutin and colleagues (pp. 370–382) present a new mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4082858accda8d065e04fda5509b5bd8
https://doi.org/10.1101/gad.297630.117
https://doi.org/10.1101/gad.297630.117