The prevalence of Post-Ebola Syndrome hearing loss, Sierra Leone

Autor: Samuel C. Ficenec, Donald S. Grant, Ibrahim Sumah, Foday Alhasan, Mohamed S. Yillah, Jenneh Brima, Edwin Konuwa, Michael A. Gbakie, Fatima K. Kamara, Nell G. Bond, Emily J. Engel, Jeffrey G. Shaffer, William A. Fischer, David A. Wohl, Susan D. Emmett, John S. Schieffelin

Publikováno v: BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-11 (2022)

Abstract Background Globally, hearing loss is the second leading cause of disability, affecting approximately 18.7% of the world’s population. However, the burden of hearing loss is unequally distributed, with the majority of affected individuals l

Externí odkaz: https://doaj.org/article/198778c878c1470b9209ddacc98b607f

The Origins and Future of Sentinel: An Early-Warning System for Pandemic Preemption and Response

Autor: Yolanda Botti-Lodovico, Parvathy Nair, Dolo Nosamiefan, Matthew Stremlau, Stephen Schaffner, Sebastian V. Agignoae, John Oke Aiyepada, Fehintola V. Ajogbasile, George O. Akpede, Foday Alhasan, Kristian G. Andersen, Danny A. Asogun, Oladele Oluwafemi Ayodeji, Aida S. Badiane, Kayla Barnes, Matthew R. Bauer, Antoinette Bell-Kareem, Muoebonam Ekene Benard, Ebo Ohomoime Benevolence, Osiemi Blessing, Chloe K. Boehm, Matthew L. Boisen, Nell G. Bond, Luis M. Branco, Michael J. Butts, Amber Carter, Andres Colubri, Awa B. Deme, Katherine C. DeRuff, Younousse Diédhiou, Akhilomen Patience Edamhande, Siham Elhamoumi, Emily J. Engel, Philomena Eromon, Mosoka Fallah, Onikepe A. Folarin, Ben Fry, Robert Garry, Amy Gaye, Michael Gbakie, Sahr M. Gevao, Gabrielle Gionet, Adrianne Gladden-Young, Augustine Goba, Jules Francois Gomis, Anise N. Happi, Mary Houghton, Chikwe Ihekwuazu, Christopher Ojemiega Iruolagbe, Jonathan Jackson, Simbirie Jalloh, Jeremy Johnson, Lansana Kanneh, Adeyemi Kayode, Molly Kemball, Ojide Chiedozie Kingsley, Veronica Koroma, Dylan Kotliar, Samar Mehta, Hayden C. Metsky, Airende Michael, Marzieh Ezzaty Mirhashemi, Kayvon Modjarrad, Mambu Momoh, Cameron A. Myhrvold, Okonofua Grace Naregose, Tolla Ndiaye, Mouhamadou Ndiaye, Aliou Ndiaye, Erica Normandin, Ikponmwosa Odia, Judith Uche Oguzie, Sylvanus A. Okogbenin, Peter O. Okokhere, Johnson Okolie, Idowu B. Olawoye, Testimony J. Olumade, Paul E. Oluniyi, Omigie Omoregie, Daniel J. Park, Mariétou Faye Paye, Brittany Petros, Anthony A. Philippakis, Abechi Priscilla, Alan Ricks, Anne Rimoin, John Demby Sandi, John S. Schieffelin, Monica Schreiber, Mame Cheikh Seck, Sameed Siddiqui, Katherine Siddle, Allison R. Smither, Mouhamad Sy, Ngayo Sy, Christopher H. Tomkins-Tinch, Oyewale Tomori, Chinedu Ugwu, Jessica N. Uwanibe, Eghosasere Anthonia Uyigue, Dada Ireti Victoria, Anika Vinzé, Megan E. Vodzak, Nicole Welch, Haja Isatta Wurie, Daba Zoumarou, Donald S. Grant, Daouda Ndiaye, Bronwyn MacInnis, Pardis C. Sabeti, Christian Happi

Publikováno v: Viruses, Vol 13, Iss 8, p 1605 (2021)

While investigating a signal of adaptive evolution in humans at the gene LARGE, we encountered an intriguing finding by Dr. Stefan Kunz that the gene plays a critical role in Lassa virus binding and entry. This led us to pursue field work to test our

Externí odkaz: https://doaj.org/article/fdc2cdf7bd364441a6c4a021de0b3451

Antibody Responses In Non-Severe SARS-CoV-2 Infections Are Driven By CD4+ T cells and Age

Autor: Amelie E. Murrell, Ewono Eyoh, Jeffrey G. Shaffer, Monika L. Dietrich, Ivy V. Trinh, Thomas J. Yockachonis, Shuangyi Bai, Crystal Y. Zheng, Celia V. Mayne, Sofia E. Cabrera, Anyssa Aviles-Amaro, Addison E. Stone, Saraswatie Rambaran, Sruti Chandra, Debra H. Elliott, Ashley R. Smira, Sara N. Harris, Katharine E. Olson, Samantha J. Bilton, Medea J. Gabriel, Nicole D. Falgout, Emily J. Engel, Alisha D. Prystowsky, Bo Ning, Tony Hu, Jay K. Kolls, Samuel J. Landry, Stacy S. Drury, John S. Schieffelin, Kevin J. Zwezdaryk, James E. Robinson, Bronwyn M. Gunn, Elizabeth B. Norton

SUMMARYSARS-CoV-2 infection causes a spectrum of clinical outcomes and diverse memory responses. Population studies indicate that viral neutralizing antibody responses are protective, but do not always develop post-infection. Other antiviral antibody

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::651a40f7e10a61d64575925de7e3064f
https://doi.org/10.1101/2022.04.22.22274032

Lassa Fever among Children in Eastern Province, Sierra Leone: A 7-year Retrospective Analysis (2012–2018)

Autor: Joseph R. Starnes, John S. Schieffelin, Donald S. Grant, Robert J. Samuels, Emily J Engel, Troy D. Moon, Augustine Goba, John Demby Sandi, Mambu Momoh, Robert F. Garry, Veronica J. Koroma, Foday Alhasan, Michael Gbakie, Jeffrey G. Shaffer

Publikováno v: The American Journal of Tropical Medicine and Hygiene

Pediatric Lassa fever (LF) usually presents as a nonspecific febrile illness, similar to other endemic diseases in countries like Sierra Leone, where LF is considered to be hyperendemic. The nonspecificity of presentation and lack of research have ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1878167a486974ce40e2c7acb14e3ab2
http://europepmc.org/articles/PMC7866338

Post-Ebola Syndrome Presents With Multiple Overlapping Symptom Clusters: Evidence From an Ongoing Cohort Study in Eastern Sierra Leone

Autor: Nell G. Bond, Adaora Okoli, Robert J. Samuels, Michael Gbakie, William A. Fischer, Don Grant, Jeffrey G. Shaffer, Foday Alhasan, David A. Wohl, Robert F. Garry, Ibrahim Mustapha, Fatima Kamara, Emily J Engel, Lansana Kanneh, John S. Schieffelin, Sarah Talia Himmelfarb

Publikováno v: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

Background Following the 2013–2016 West African Ebola outbreak, distinct, persistent health complaints were recognized in Ebola virus disease (EVD) survivors. Here we provide an in-depth characterization of post-Ebola syndrome >2.5 years after reso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e298d95630b1c81efd49ac8f877fdeb4
https://pubmed.ncbi.nlm.nih.gov/33870418