Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Emily Gwyer"'
Autor:
Katie J Smith, Danielle Minns, Brian J McHugh, Rebecca K Holloway, Richard O'Connor, Anna Williams, Lauren Melrose, Rhoanne McPherson, Veronique E Miron, Donald J Davidson, Emily Gwyer Findlay
Publikováno v:
PLoS Biology, Vol 20, Iss 8, p e3001554 (2022)
Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear. The IL-17-producing Th17 subset of T cells has been widely implicated in MS and in the mouse model,
Externí odkaz:
https://doaj.org/article/6092c03798ea4893825a68dc61de5313
Autor:
Danielle Minns, Katie J. Smith, Virginia Alessandrini, Gareth Hardisty, Lauren Melrose, Lucy Jackson-Jones, Andrew S. MacDonald, Donald J. Davidson, Emily Gwyer Findlay
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Neutrophils secrete numerous immune effector molecules including cathelicidin which is associated with antimicrobial properties. Here the authors implicate neutrophil derived cathelicidin in modulation of CD4 T cell homoeostasis and the promotion of
Externí odkaz:
https://doaj.org/article/575b66e7e8b04cad96678a2c55c7e867
Autor:
Tom M. Quinn, Erin E. Gaughan, Annya Bruce, Jean Antonelli, Richard O'Connor, Feng Li, Sarah McNamara, Oliver Koch, Claire MacKintosh, David Dockrell, Timothy Walsh, Kevin G. Blyth, Colin Church, Jürgen Schwarze, Cecilia Boz, Asta Valanciute, Matthew Burgess, Philip Emanuel, Bethany Mills, Giulia Rinaldi, Gareth Hardisty, Ross Mills, Emily Gwyer Findlay, Sunny Jabbal, Andrew Duncan, Sinéad Plant, Adam D.L. Marshall, Irene Young, Kay Russell, Emma Scholefield, Alastair F. Nimmo, Islom B. Nazarov, Grant C. Churchill, James S.O. McCullagh, Kourosh H. Ebrahimi, Colin Ferrett, Kate Templeton, Steve Rannard, Andrew Owen, Anne Moore, Keith Finlayson, Manu Shankar-Hari, John Norrie, Richard A. Parker, Ahsan R. Akram, Daniel C. Anthony, James W. Dear, Nik Hirani, Kevin Dhaliwal
Publikováno v:
EBioMedicine, Vol 76, Iss , Pp 103856- (2022)
Summary: Background: Many repurposed drugs have progressed rapidly to Phase 2 and 3 trials in COVID19 without characterisation of Pharmacokinetics /Pharmacodynamics including safety data. One such drug is nafamostat mesylate. Methods: We present the
Externí odkaz:
https://doaj.org/article/30aabc317f5544bcb011f0340db28762
Autor:
Gareth R. Hardisty, Frances Llanwarne, Danielle Minns, Jonathan L. Gillan, Donald J. Davidson, Emily Gwyer Findlay, Robert D. Gray
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Low density neutrophils (LDNs) are described in a number of inflammatory conditions, cancers and infections and associated with immunopathology, and a mechanistic role in disease. The role of LDNs at homeostasis in healthy individuals has not been in
Externí odkaz:
https://doaj.org/article/ef201149d27142c98fc2a4833c490b41
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophils and T cells exist in close proximity in lymph nodes and inflamed tissues during health and disease. They are able to form stable interactions, with profound effects on the phenotype and function of the T cells. However, the outcome of the
Externí odkaz:
https://doaj.org/article/991e9ab501f2406ba19b400e1e2501b7
Autor:
Emily Gwyer Findlay, Andrew J. Currie, Ailiang Zhang, Jana Ovciarikova, Lisa Young, Holly Stevens, Brian J. McHugh, Marta Canel, Mohini Gray, Simon W.F. Milling, John D.M. Campbell, John Savill, Alan Serrels, Donald J. Davidson
Publikováno v:
OncoImmunology, Vol 8, Iss 8 (2019)
Immunization of patients with autologous, ex vivo matured dendritic cell (DC) preparations, in order to prime antitumor T-cell responses, is the focus of intense research. Despite progress and approval of clinical approaches, significant enhancement
Externí odkaz:
https://doaj.org/article/8c619a0ba3fa49a6a60740bf5be1c638
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Neutrophils are the most abundant leukocytes in peripheral blood and respond rapidly to danger, infiltrating tissues within minutes of infectious or sterile injury. Neutrophils were long thought of as simple killers, but now we recognise them as resp
Externí odkaz:
https://doaj.org/article/c15763243f844959bc39460b9eb807b7
Autor:
Paula E Beaumont, Brian McHugh, Emily Gwyer Findlay, Annie Mackellar, Karen J Mackenzie, Richard L Gallo, John R W Govan, A John Simpson, Donald J Davidson
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99029 (2014)
Cathelicidins are multifunctional cationic host-defence peptides (CHDP; also known as antimicrobial peptides) and an important component of innate host defence against infection. In addition to microbicidal potential, these peptides have properties w
Externí odkaz:
https://doaj.org/article/0fbf999318614893be87e3f90c106aae
Autor:
Ana Villegas-Mendez, J Brian de Souza, Seen-Wai Lavelle, Emily Gwyer Findlay, Tovah N Shaw, Nico van Rooijen, Christiaan J Saris, Christopher A Hunter, Eleanor M Riley, Kevin N Couper
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003293 (2013)
The IL-27R, WSX-1, is required to limit IFN-γ production by effector CD4⁺ T cells in a number of different inflammatory conditions but the molecular basis of WSX-1-mediated regulation of Th1 responses in vivo during infection has not been investig
Externí odkaz:
https://doaj.org/article/0a9fcc6cf8cd4e8ca876915393761c65
Autor:
Ana Villegas-Mendez, Emily Gwyer Findlay, J Brian de Souza, Lisa-Marie Grady, Christiaan J Saris, Thomas E Lane, Eleanor M Riley, Kevin N Couper
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78486 (2013)
IL-27 is an important and non-redundant regulator of effector T cell accumulation in non-lymphoid tissues during infection. Using malaria as a model systemic pro-inflammatory infection, we demonstrate that the aberrant accumulation of CD4⁺ T cells
Externí odkaz:
https://doaj.org/article/bce17db5a2f5487b90213c4f7e5a4843