Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Emily Gudvangen"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Ablation therapies aim at eradication of tumors with minimal impact on surrounding healthy tissues. Conventional pulsed electric field (PEF) treatments cause pain and muscle contractions far beyond the ablation area. The ongoing quest is to
Externí odkaz:
https://doaj.org/article/e1a7318d9abb4d3d85666cbb65639cd6
Autor:
Pamela W. Sowa, Aleksander S. Kiełbik, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Volker Adams, Olga N. Pakhomova
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Electric shocks, the only effective therapy for ventricular fibrillation, also electroporate cardiac cells and contribute to the high-mortality post-cardiac arrest syndrome. Copolymers such as Poloxamer 188 (P188) are known to preserve the membrane i
Externí odkaz:
https://doaj.org/article/358634790a3b4390b8c7673860881b99
Autor:
Emily Gudvangen, Uma Mangalanathan, Iurii Semenov, Allen S. Kiester, Mark A. Keppler, Bennett L. Ibey, Joel N. Bixler, Andrei G. Pakhomov
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2854 (2023)
Cancer ablation therapies aim to be efficient while minimizing damage to healthy tissues. Nanosecond pulsed electric field (nsPEF) is a promising ablation modality because of its selectivity against certain cell types and reduced neuromuscular effect
Externí odkaz:
https://doaj.org/article/2cb49b584fa24bf1b6d26c216e9e8c31
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 7051 (2021)
Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong involuntary muscle contractions and pain. Nanosecond-range PEF
Externí odkaz:
https://doaj.org/article/3768f64f89c449358530ace7bfb8a861
Autor:
Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Oleg Kondratiev, Luis Redondo, Iurii Semenov
Publikováno v:
Bioelectrochemistry. 152:108437
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eddd0079d3adb5798c0a430848dd33c
https://doi.org/10.1016/j.bioelechem.2023.108437
https://doi.org/10.1016/j.bioelechem.2023.108437
Autor:
Aleksander Kiełbik, Pamela W. Sowa, Andrei G. Pakhomov, Emily Gudvangen, Uma Mangalanathan, Julita Kulbacka, Olga N. Pakhomova
Publikováno v:
Bioelectrochemistry (Amsterdam, Netherlands). 149
The quest for safe and effective ablation resulted in the development of nanosecond pulsed electric fields (nsPEF) technology for tumor treatment. For future applications of nsPEF in urothelial cancer treatment, we evaluated the effect of urine prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb4f44740c24d59c06295212d14db95
https://pubmed.ncbi.nlm.nih.gov/36270049
https://pubmed.ncbi.nlm.nih.gov/36270049
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1864:184034
Neuromodulation applications of nanosecond electric pulses (nsEP) are hindered by their low potency to elicit action potentials in neurons. Excitation by a single nsEP requires a strong electric field which injures neurons by electroporation. We bypa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c9bc94a6a785d198cd4f181550569b
https://doi.org/10.1016/j.bbamem.2022.184034
https://doi.org/10.1016/j.bbamem.2022.184034
Autor:
Sayak, Bhattacharya, Mantas, Silkunas, Emily, Gudvangen, Uma, Mangalanathan, Olga N, Pakhomova, Andrei G, Pakhomov
Publikováno v:
Biochimica et biophysica acta. Biomembranes. 1864(2)
Electroporation, in particular with nanosecond pulses, is an efficient technique to generate nanometer-size membrane lesions without the use of toxins or other chemicals. The restoration of the membrane integrity takes minutes and is only partially d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe67df51915eb97a6ac6c617aa798f56
https://pubmed.ncbi.nlm.nih.gov/34838875
https://pubmed.ncbi.nlm.nih.gov/34838875
Autor:
Mantas Silkunas, Sayak Bhattacharya, Emily Gudvangen, Uma Mangalanathan, Olga N. Pakhomova, Andrei G. Pakhomov
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1864:183823
Electroporation, in particular with nanosecond pulses, is an efficient technique to generate nanometer-size membrane lesions without the use of toxins or other chemicals. The restoration of the membrane integrity takes minutes and is only partially d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3302a2069587a9d58524bc895772b730
https://doi.org/10.1016/j.bbamem.2021.183823
https://doi.org/10.1016/j.bbamem.2021.183823
Publikováno v:
Bioelectrochemistry. 141:107876
Stimulation and electroporation by nanosecond electric pulses (nsEP) are distinguished by a phenomenon of bipolar cancellation, which stands for a reduced efficiency of bipolar pulses compared to unipolar ones. When two pairs of stimulating electrode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620a731ec385c77f9fe47a1b4d59f6a9
https://doi.org/10.1016/j.bioelechem.2021.107876
https://doi.org/10.1016/j.bioelechem.2021.107876