Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Emily G. Saccuzzo"'
Autor:
Emily G. Saccuzzo, Mubark D. Mebrat, Hailee F. Scelsi, Minjoo Kim, Minh Thu Ma, Xinya Su, Shannon E. Hill, Elisa Rheaume, Renhao Li, Matthew P. Torres, James C. Gumbart, Wade D. Van Horn, Raquel L. Lieberman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Studies of folded-to-misfolded transitions using model protein systems reveal a range of unfolding needed for exposure of amyloid-prone regions for subsequent fibrillization. Here, we probe the relationship between unfolding and aggregation
Externí odkaz:
https://doaj.org/article/d4c43b083a34447bb38dec82f348044d
Autor:
Emily G. Saccuzzo, Mackenzie D. Martin, Kamisha R. Hill, Minh Thu Ma, Yemo Ku, Raquel L. Lieberman
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 27:553-564
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9742009be06e4356696cad6be4477b10
https://doi.org/10.1007/s00775-022-01946-3
https://doi.org/10.1007/s00775-022-01946-3
Publikováno v:
Progress in Retinal and Eye Research. 95:101188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8487aa0e6e48f9929cf6e8266393de3
https://doi.org/10.1016/j.preteyeres.2023.101188
https://doi.org/10.1016/j.preteyeres.2023.101188
Autor:
Santi Mestre-Fos, Nicholas V. Hud, Anton S. Petrov, Raquel L. Lieberman, Bettina Bommarius, Kavita R. Matange, Loren Dean Williams, Anton V. Bryksin, Brett M. Barlow, Vinayak Agarwal, Gwendell Thomas, Robert G. Mannino, Pamela Pollet, Jennifer B. Glass, Chieri Ito, Emily G. Saccuzzo, Jessica C. Bowman, Mallory Hazell, Rebecca K. Donegan, Nguyet A. Nguyen, Samantha J. Mascuch, Suneesh C. Karunakaran, Hem R. Thapa, Gary P. Newnam, Andrés J. García, Brooke Rothschild-Mancinelli, Chiamaka T. Obianyor, Carolyn B. Ibberson, Sara Fakhretaha-Aval, Wilbur A. Lam, Liangjun Zhao, Minh Thu H. Ma, Rebecca Guth-Metzler, Julia Kubanek, Petar I. Penev
Publikováno v:
Journal of Biological Chemistry
Widespread testing for the presence of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment. Challenges in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c475667bc2d71dfb929e97b52e3b2b8d
https://doi.org/10.1074/jbc.ra120.015434
https://doi.org/10.1074/jbc.ra120.015434
Publikováno v:
Hum Mutat
Rare variants of the olfactomedin domain of myocilin are considered causative for inherited, early-onset open angle glaucoma, with a misfolding toxic gain of function pathogenic mechanism detailed by 20 years of laboratory research. Myocilin variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effbe99bb48210bc937b0c3f1b68386d
https://europepmc.org/articles/PMC8295199/
https://europepmc.org/articles/PMC8295199/
Autor:
Anant K. Paravastu, Emily G. Saccuzzo, Dustin J. E. Huard, Raquel L. Lieberman, Alicia S Robang, Yuan Gao, Shannon E. Hill
Publikováno v:
J Phys Chem B
Myocilin-associated glaucoma is a new addition to the list of diseases linked to protein misfolding and amyloid formation. Single point variants of the ∼257-residue myocilin olfactomedin domain (mOLF) lead to mutant myocilin aggregation. Here, we a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9818b37ed9bf2df1654d90d421c6599a
https://pubmed.ncbi.nlm.nih.gov/33683890
https://pubmed.ncbi.nlm.nih.gov/33683890