Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Emily G. Knox"'
Autor:
Faith Conroy, Rachael Miller, Julia F. Alterman, Matthew R. Hassler, Dimas Echeverria, Bruno M. D. C. Godinho, Emily G. Knox, Ellen Sapp, Jaquelyn Sousa, Ken Yamada, Farah Mahmood, Adel Boudi, Kimberly Kegel-Gleason, Marian DiFiglia, Neil Aronin, Anastasia Khvorova, Edith L. Pfister
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Chemically modified siRNAs distinguish between mutant and normal huntingtin based on a single nucleotide difference and lower mutant huntingtin specifically in patient derived cells and in a mouse model of Huntington’s disease.
Externí odkaz:
https://doaj.org/article/b3726cec35ca4048a177c94f5d18c4bd
Autor:
Bruno M.D.C. Godinho, Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy, Reka A. Haraszti, Chantal M. Ferguson, Andrew H. Coles, Annabelle Biscans, Jillian Caiazzi, Julia F. Alterman, Matthew R. Hassler, Anastasia Khvorova
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 116-132 (2022)
Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in limited blood residence times and tissue exposure.
Externí odkaz:
https://doaj.org/article/085fd4bc93584da8ae49dde6a3e10019
Autor:
Chantal M. Ferguson, Bruno M.D.C. Godinho, Julia F. Alterman, Andrew H. Coles, Matthew Hassler, Dimas Echeverria, James W. Gilbert, Emily G. Knox, Jillian Caiazzi, Reka A. Haraszti, Robert M. King, Toloo Taghian, Ajit Puri, Richard P. Moser, Matthew J. Gounis, Neil Aronin, Heather Gray-Edwards, Anastasia Khvorova
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
siRNAs comprise a class of drugs that can be programmed to silence any target gene. Chemical engineering efforts resulted in development of divalent siRNAs (di-siRNAs), which support robust and long-term efficacy in rodent and nonhuman primate brains
Externí odkaz:
https://doaj.org/article/6446b294c4ec4d69983aef3f4ec8e137
Publikováno v:
Molecular Psychiatry. 27:2659-2673
The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the brain parenchyma. Moreover, the BBB prevents unwanted toxins and pathogens from entering the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e5544f87a38f6b7683a00b7f066ff7d
https://doi.org/10.1038/s41380-022-01511-z
https://doi.org/10.1038/s41380-022-01511-z
Autor:
null Emily G. Knox, null Caoimhe M. K. Lynch, null Ye Seul Lee, null Caitriona M. O'Driscoll, null Gerard Clarke, null John F. Cryan, null Maria R. Aburto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02c15c7418417f5524b401fafd37237e
https://doi.org/10.1111/ejn.15878/v2/response1
https://doi.org/10.1111/ejn.15878/v2/response1
Autor:
Emily G. Knox, Caoimhe M. K. Lynch, Ye Seul Lee, Caitriona M. O'Driscoll, Gerard Clarke, John F. Cryan, Maria R. Aburto
Publikováno v:
The European journal of neuroscience.
The gut microbiota communicates with the brain though several pathways including the vagus nerve, immune system, microbial metabolites, and through the endocrine system. Pathways along the humoral/immune gut-microbiota-brain axis comprise of a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3944d32a66d4d6a47b136d0aaeaefda0
https://pubmed.ncbi.nlm.nih.gov/36453579
https://pubmed.ncbi.nlm.nih.gov/36453579
Autor:
Emily G. Knox, Maria R. Aburto, Carmen Tessier, Jatin Nagpal, Gerard Clarke, Caitriona M. O’Driscoll, John F. Cryan
Publikováno v:
iScience. 25(12)
The gut microbiota influences host brain function, but the underlying gut-brain axis connections and molecular processes remain unclear. One pathway along this bidirectional communication system involves circulating microbially derived metabolites, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062c3af446abf88687f7a508fa5f2d5f
https://pubmed.ncbi.nlm.nih.gov/36505934
https://pubmed.ncbi.nlm.nih.gov/36505934
Autor:
Faith Conroy, Rachael Miller, Julia F. Alterman, Matthew R. Hassler, Dimas Echeverria, Bruno M.D.C. Godinho, Emily G. Knox, Ellen Sapp, Jaquelyn Sousa, Ken Yamada, Farah Mahmood, Adel Boudi, Kimberly Kegel-Gleason, Marian DiFiglia, Neil Aronin, Anastasia Khvorova, Edith L. Pfister
Small interfering RNAs (siRNAs) are a new class of drugs, exhibiting sequence-driven, potent, and sustained silencing of gene expressionin vivo. We recently demonstrated that siRNA chemical architectures can be optimized to provide efficient delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526157da8750a9e83cee9dc8b075a425
https://doi.org/10.1101/2022.06.29.498088
https://doi.org/10.1101/2022.06.29.498088
Autor:
Jacquelyn Sousa, Emily G. Knox, Anastasia Khvorova, Julia F. Alterman, Dimas Echeverria, Sarah M. Davis, Anton A. Turanov, Matthew R. Hassler, Lorenc Vangjeli
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss, Pp 266-277 (2020)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Small interfering RNAs (siRNAs) have the potential to treat a broad range of diseases. siRNAs need to be extensively chemically modified to improve their bioavailability, safety, and stability in vivo. However, chemical modifications variably impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::109ca8c2f8da0084d8db9f9e473d441d
http://www.sciencedirect.com/science/article/pii/S2162253120301360
http://www.sciencedirect.com/science/article/pii/S2162253120301360
Autor:
Bruno M.D.C. Godinho, Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy, Reka A. Haraszti, Chantal M. Ferguson, Andrew H. Coles, Annabelle Biscans, Jillian Caiazzi, Julia F. Alterman, Matthew R. Hassler, Anastasia Khvorova
Publikováno v:
Molecular therapy. Nucleic acids. 29
Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in limited blood residence times and tissue exposure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd39e96a4b625a2ba816cdd45a4041a
https://pubmed.ncbi.nlm.nih.gov/35795486
https://pubmed.ncbi.nlm.nih.gov/35795486