Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Emily G. Kaye"'
Autor:
Emily G. Kaye, Kavyashree Basavaraju, Geoffrey M. Nelson, Helena D. Zomer, Debarun Roy, Irene Infancy Joseph, Reza Rajabi-Toustani, Huanyu Qiao, Karen Adelman, Prabhakara P. Reddi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Male germ cell development requires precise regulation of gene activity in a cell-type and stage-specific manner, with perturbations in gene expression during spermatogenesis associated with infertility. Here, we use steady-state, nascent an
Externí odkaz:
https://doaj.org/article/dde5609169b7435cbf7f1eda489eb40f
Autor:
Emily G. Kaye, Matthew Booker, Jesse V. Kurland, Alexander E. Conicella, Nicolas L. Fawzi, Martha L. Bulyk, Michael Y. Tolstorukov, Erica Larschan
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3227-3239 (2018)
Summary: Little is known about how variation in sequence composition alters transcription factor occupancy to precisely recruit large transcription complexes. A key model for understanding how transcription complexes are targeted is the Drosophila do
Externí odkaz:
https://doaj.org/article/571743602286407cb10426777cb6913f
Autor:
Emily G. Kaye, Geoffrey M. Nelson, Helena D. Zomer, Debarun Roy, Irene Infancy Joseph, Karen Adelman, Prabhakara P. Reddi
Male germ cell development requires precise regulation of gene activity in a cell-type and stage-specific manner, with perturbations in gene expression during spermatogenesis associated with infertility. Here, we use steady-state, nascent and single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::671de899a22eed40556c674ccba70b09
https://doi.org/10.1101/2023.05.08.539879
https://doi.org/10.1101/2023.05.08.539879
Autor:
Guray Kuzu, Emily G Kaye, Jessica Chery, Trevor Siggers, Lin Yang, Jason R Dobson, Sonia Boor, Jacob Bliss, Wei Liu, Gerwald Jogl, Remo Rohs, Nadia D Singh, Martha L Bulyk, Michael Y Tolstorukov, Erica Larschan
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006120 (2016)
Dosage compensation is an essential process that equalizes transcript levels of X-linked genes between sexes by forming a domain of coordinated gene expression. Throughout the evolution of Diptera, many different X-chromosomes acquired the ability to
Externí odkaz:
https://doaj.org/article/059126ee109c4fffbd67b17d9cc244b2
Autor:
Wenqi Xu, Chenxi He, Emily G. Kaye, Jiahui Li, Mandi Mu, Geoffrey M. Nelson, Li Dong, Jiahua Wang, Feizhen Wu, Yujiang Geno Shi, Karen Adelman, Fei Lan, Yang Shi, Hongjie Shen
Publikováno v:
Molecular Cell. 82:1156-1168.e7
N6-methyladenosine (m6A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m6A on transcription remains poorly understood. Here, we demonstrate that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) is localized
Autor:
Wenqi, Xu, Chenxi, He, Emily G, Kaye, Jiahui, Li, Mandi, Mu, Geoffrey M, Nelson, Li, Dong, Jiahua, Wang, Feizhen, Wu, Yujiang Geno, Shi, Karen, Adelman, Fei, Lan, Yang, Shi, Hongjie, Shen
Publikováno v:
Mol Cell
N(6)-methyladenosine (m(6)A) methylation is co-transcriptionally deposited on mRNA, but a possible role of m(6)A on transcription remains poorly understood. Here, we demonstrate that the METTL3/METTL14/WTAP m(6)A methyltransferase complex (MTC) is lo
Autor:
Jesse V. Kurland, Nicolas L. Fawzi, Martha L. Bulyk, Alexander E. Conicella, Emily G. Kaye, Erica Larschan, Matthew A. Booker, Michael Y. Tolstorukov
Publikováno v:
Cell Reports, Vol 22, Iss 12, Pp 3227-3239 (2018)
Cell reports
Cell reports
SUMMARY Little is known about how variation in sequence composition alters transcription factor occupancy to precisely recruit large transcription complexes. A key model for understanding how transcription complexes are targeted is the Drosophila dos
Publikováno v:
Molecular and Cellular Biology. 37
Chromatin entry sites (CES) are 100- to 1,500-bp elements that recruit male-specific lethal (MSL) complexes to the X chromosome to upregulate expression of X-linked genes in male flies. CES contain one or more ∼20-bp GA-rich sequences called MSL re
Autor:
Jason R. Dobson, Lin Yang, Jessica Chery, Trevor Siggers, Nadia D. Singh, Gerwald Jogl, Wei Liu, Remo Rohs, Sonia Boor, Michael Y. Tolstorukov, Martha L. Bulyk, Emily G. Kaye, Guray Kuzu, Jacob E. Bliss, Erica Larschan
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 7, p e1006120 (2016)
PLoS Genetics, Vol 12, Iss 7, p e1006120 (2016)
Dosage compensation is an essential process that equalizes transcript levels of X-linked genes between sexes by forming a domain of coordinated gene expression. Throughout the evolution of Diptera, many different X-chromosomes acquired the ability to
Autor:
Kayla M. Gross, Kristen N. Robinson, Jo Bellairs, Emily V. Sher, Emily G. Kaye, Lindsay E. Dale, Catherine Gallagher, Kevin P. Rice
Publikováno v:
Cancer Research. 72:1764-1764
Laromustine is an experimental anticancer drug that has been tested in the clinic against acute myelogenous leukemia and glioblastoma multiforme. In the body, Laromustine's cytotoxic effects are a result of two cogenerated electrophiles, a 2-chloroet