Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Emily F Davis-Marcisak"'
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Akademický článek
Evaluation of both exonic and intronic variants for effects on RNA splicing allows for accurate assessment of the effectiveness of precision therapies.
Autor: Anya T Joynt, Taylor A Evans, Matthew J Pellicore, Emily F Davis-Marcisak, Melis A Aksit, Alice C Eastman, Shivani U Patel, Kathleen C Paul, Derek L Osorio, Alyssa D Bowling, Calvin U Cotton, Karen S Raraigh, Natalie E West, Christian A Merlo, Garry R Cutting, Neeraj Sharma
Publikováno v: PLoS Genetics, Vol 16, Iss 10, p e1009100 (2020)
Elucidating the functional consequence of molecular defects underlying genetic diseases enables appropriate design of therapeutic options. Treatment of cystic fibrosis (CF) is an exemplar of this paradigm as the development of CFTR modulator therapie
Externí odkaz: https://doaj.org/article/d474085b9069492aac9a9a9d1b71d72f
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6
Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines
Autor: Emily F. Davis-Marcisak, Fernando T. Zamuner, Michael Considine, Srinivasan Yegnasubramanian, Elana J. Fertig, Luciane T. Kagohara, Daria A. Gaykalova, Gaurav Sharma, Jawara Allen
Publikováno v: British Journal of Cancer
Background Identifying potential resistance mechanisms while tumour cells still respond to therapy is critical to delay acquired resistance. Methods We generated the first comprehensive multi-omics, bulk and single-cell data in sensitive head and nec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7cebf7852899b34df480dfcbbf5b7f
http://europepmc.org/articles/PMC7341752
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7
Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors
Autor: Elana J. Fertig, Allison A. Fitzgerald, Michael D. Kessler, Emily F. Davis-Marcisak, Elizabeth M. Jaffee, Ludmila Danilova, Neeha Zaidi, Louis M. Weiner
Publikováno v: Genome Medicine
Genome Medicine, Vol 13, Iss 1, Pp 1-22 (2021)
BackgroundTumor response to therapy is affected by both the cell types and the cell states present in the tumor microenvironment. This is true for many cancer treatments, including immune checkpoint inhibitors (ICIs). While it is well-established tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb23248dd31c71d267a009f73643a1f
https://doi.org/10.1186/s13073-021-00944-5
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8
Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response
Autor: Hanwen Wang, Shuming Zhang, Emily F. Davis-Marcisak, Aleksander S. Popel, Alvaro Ruiz-Martinez, Atul Deshpande, Chang Gong, Elana J. Fertig
Publikováno v: Immunoinformatics (Amsterdam, Netherlands)
Response to cancer immunotherapies depends on the complex and dynamic interactions between T cell recognition and killing of cancer cells that are counteracted through immunosuppressive pathways in the tumor microenvironment. Therefore, while measure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de719e6e9b0fef7fe4e8f28e203f9987
http://europepmc.org/articles/PMC8547770
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9
Correlating Cystic Fibrosis Transmembrane Conductance Regulator Function with Clinical Features to Inform Precision Treatment of Cystic Fibrosis
Autor: Matthew J. Pellicore, Taylor A. Evans, Anya T. Joynt, Zhongzhou Lu, Mary Corey, Sangwoo T. Han, Garry R. Cutting, Allison F. McCague, Neeraj Sharma, Karen S. Raraigh, Chris M. Penland, Anne L. Stephenson, Johanna M. Rommens, Michelle Huckaby Lewis, Emily F. Davis-Marcisak, Joseph M. Collaco, Carlo Castellani, Patrick R. Sosnay
Publikováno v: Am J Respir Crit Care Med
American Journal of Respiratory and Critical Care Medicine
Rationale: The advent of precision treatment for cystic fibrosis using small-molecule therapeutics has created a need to estimate potential clinical improvements attributable to increases in cystic fibrosis transmembrane conductance regulator (CFTR)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969190bd764f2f0aa9499632736c6bd6
https://doi.org/10.1164/rccm.201901-0145oc
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10
From bench to bedside: Single-cell analysis for cancer immunotherapy
Autor: Elizabeth M. Jaffee, Emily F. Davis-Marcisak, Luciane T. Kagohara, Daniel A. Laheru, Genevieve Stein-O’Brien, Elana J. Fertig, Won Jin Ho, Atul Deshpande
Publikováno v: Cancer Cell
Summary Single-cell technologies are emerging as powerful tools for cancer research. These technologies characterize the molecular state of each cell within a tumor, enabling new exploration of tumor heterogeneity, microenvironment cell-type composit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67bdb53d109a472bca1359ec982ff4c
https://pubmed.ncbi.nlm.nih.gov/34329587
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