Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Emily E. Reid"'
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Tumor-selective delivery of cytotoxic agents in the form of antibody–drug conjugates (ADCs) is now a clinically validated approach for cancer treatment. In an attempt to improve the clinical success rate of ADCs, emphasis has been recently placed o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d1e99e32e1b6463933f4f9a2e6edc1f
https://doi.org/10.1158/1535-7163.c.6537900.v1
https://doi.org/10.1158/1535-7163.c.6537900.v1
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Comparative in vitro potency of IGNs with a diimine (1), monoimine (3), and diamine (2) towards hematologic and solid tumor cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060b3dbf22b8e72bcb6de9a2cf408c75
https://doi.org/10.1158/1535-7163.22508386
https://doi.org/10.1158/1535-7163.22508386
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Synthesis of IGNs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4d0a62fe9e14ab872c4a228aa07177
https://doi.org/10.1158/1535-7163.22508392.v1
https://doi.org/10.1158/1535-7163.22508392.v1
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Figure S1. Structural representations and scheme for preparation of IGN ADCs. Figure S2A. In vitro potency comparing ADCs of an IGN DNA cross-linker and DNA alkylator. Figure S2B. In vitro potency comparing ADCs of an IGN DNA cross-linker and DNA alk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f568423d203af13cedff0663cdc34a8
https://doi.org/10.1158/1535-7163.22504929.v1
https://doi.org/10.1158/1535-7163.22504929.v1
Autor:
Ravi V.J. Chari, Thomas A. Keating, Jan Pinkas, Olga Ab, Katharine C. Lai, Yelena Kovtun, Nicholas C. Yoder, Jose F. Ponte, Rajeeva Singh, Luke Harris, Dilrukshi Vitharana, Chen Bai, Katie E. Archer, Qifeng Qiu, Lauren Harvey, Erin K. Maloney, Surina Sikka, Leanne Lanieri, Emily E. Reid, Paulin Salomon, Alan Wilhelm, Manami Shizuka, Michael L. Miller
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6fcae1da3f382759fcd9ae562eb2f6
https://doi.org/10.1158/1535-7163.22504926.v1
https://doi.org/10.1158/1535-7163.22504926.v1
Autor:
Ravi V.J. Chari, John M. Lambert, Victor Goldmacher, Jan Pinkas, Rajeeva Singh, Holly A. Modafferi, Alan Wilhelm, Michele F. Mayo, Charlene A. Audette, Erin K. Maloney, Katie E. Archer, Emily E. Reid, Yelena Kovtun, Kathleen R. Whiteman, Wei Li, Nathan E. Fishkin, Michael L. Miller
Figure S1. Comparison of the rate of adduct formation of the indolinobenzodiazepine dimer 6 and the pyrrolobenzodiazepine dimer SJG-136 with dsDNA prepared from annealing of single strand DNA 3'-TATAGATCTATA-5'. Figure S2. A, In vitro potency of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8679b5302ba5296c6d41da8fcd17ee
https://doi.org/10.1158/1535-7163.22508395
https://doi.org/10.1158/1535-7163.22508395
Autor:
Alan Wilhelm, Paulin Salomon, Erin K. Maloney, Michael L. Miller, Emily E. Reid, Luke Harris, Thomas A. Keating, Ravi V. J. Chari, Katie E. Archer, Rajeeva Singh
Publikováno v:
Molecular Pharmaceutics. 16:4817-4825
Although peptide linkers are used in multiple clinical-stage ADCs, there are only few reports on optimizing peptide linkers for efficient lysosomal proteolysis and for stability in circulation. We screened multiple dipeptide linkers for efficiency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcf93bf37f53a74c0b2c45703584996
https://doi.org/10.1021/acs.molpharmaceut.9b00696
https://doi.org/10.1021/acs.molpharmaceut.9b00696
Autor:
Emily E. Reid, James Woods, Michael L. Miller, Manami Shizuka, Olga Ab, Alan Wilhelm, Luke Harris, Rajeeva Singh, Ravi V. J. Chari, Jose F. Ponte, Katie E. Archer, Thomas A. Keating, Laura M. Bartle, Erin K. Maloney, Yulius Setiady
Publikováno v:
ACS Med Chem Lett
[Image: see text] Indolinobenzodiazepine DNA alkylators (IGNs) are the cytotoxic payloads in antibody–drug conjugates (ADCs) currently undergoing Phase I clinical evaluation (IMGN779, IMGN632, and TAK164). These ADCs possess linkers that have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9b0f67d23684ee4267fc0573611dd8
https://doi.org/10.1021/acsmedchemlett.9b00254
https://doi.org/10.1021/acsmedchemlett.9b00254
Autor:
Katharine C. Lai, Katie E. Archer, Nicholas C. Yoder, Surina Sikka, Shan Jin, Michael L. Miller, Ravi V. J. Chari, Manami Shizuka, Alan Wilhelm, Olga Ab, Rui Wu, Erica Hong, Luke Harris, Chen Bai, Nathan Fishkin, Emily E. Reid, Paulin Salomon, Erin K. Maloney
Publikováno v:
ACS Med Chem Lett
[Image: see text] Antibody–drug conjugates (ADCs) that incorporate potent indolinobenzodiazepine DNA alkylators as the payload component are currently undergoing clinical evaluation. In one ADC design, the payload molecules are linked to the antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ee8c2ed414da9a2fe898d247efa51a
https://doi.org/10.1021/acsmedchemlett.9b00240
https://doi.org/10.1021/acsmedchemlett.9b00240
Autor:
Chen Bai, Thomas A. Keating, Sharlene Adams, Nicholas C. Yoder, Lauren Harvey, Rassol Laleau, Ravi V. J. Chari, Emily E. Reid, Alan Wilhelm, Michael L. Miller, Yelena Kovtun, Dilrukshi Vitharana, Katie E. Archer, Manami Shizuka, Erin K. Maloney
Publikováno v:
Bioconjugate chemistry. 31(1)
Antibody-drug conjugates have elicited great interest recently as targeted chemotherapies for cancer. Recent preclinical and clinical data have continued to raise questions about optimizing the design of these complex therapeutics. Biochemical method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3df138be3f04d839db34a4927c8eeaa
https://pubmed.ncbi.nlm.nih.gov/31747250
https://pubmed.ncbi.nlm.nih.gov/31747250