Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Emily E Hesketh"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131849 (2015)
Autoimmunity is associated with defective phagocytic clearance of apoptotic cells. IgM deficient mice exhibit an autoimmune phenotype consistent with a role for circulating IgM antibodies in apoptotic cell clearance. We have extensively characterised
Externí odkaz:
https://doaj.org/article/c0bdaeb162cd4d74807c13c6c7c5cd3e
Autor:
James A Richards, Martina Bucsaiova, Emily E Hesketh, Chiara Ventre, Neil C Henderson, Kenneth Simpson, Christopher O C Bellamy, Sarah E M Howie, Stephen M Anderton, Jeremy Hughes, Stephen J Wigmore
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138688 (2015)
Acute liver injury is a clinically important pathology and results in the release of Danger Associated Molecular Patterns, which initiate an immune response. Withdrawal of the injurious agent and curtailing any pathogenic secondary immune response ma
Externí odkaz:
https://doaj.org/article/f4aa703b56b14a39a5397f2753390962
Publikováno v:
F1000Research, Vol 7 (2018)
Close collaboration between specialists from diverse backgrounds and working in different scientific domains is an effective strategy to overcome challenges in areas that interface between biology, chemistry, physics and engineering. Communication in
Externí odkaz:
https://doaj.org/article/27d85b13ebac43fb86235cfe574e83f2
Improving communication for interdisciplinary teams working on storage of digital information in DNA
Publikováno v:
F1000Research
Close collaboration between specialists from diverse backgrounds and working in different scientific domains is an effective strategy to overcome challenges in areas that interface between biology, chemistry, physics and engineering. Communication in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f9b6283f3ef294a3709e5bab309ce3
https://doi.org/10.12688/f1000research.13482.1
https://doi.org/10.12688/f1000research.13482.1
Publikováno v:
Hesketh, E E, Dransfield, I, Kluth, D C & Hughes, J 2015, ' Circulating IgM Requires Plasma Membrane Disruption to Bind Apoptotic and Non-Apoptotic Nucleated Cells and Erythrocytes ', PLoS ONE, vol. 10, no. 6, pp. e0131849 . https://doi.org/10.1371/journal.pone.0131849
PLoS ONE, Vol 10, Iss 6, p e0131849 (2015)
PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0131849 (2015)
PLoS ONE
Autoimmunity is associated with defective phagocytic clearance of apoptotic cells. IgM deficient mice exhibit an autoimmune phenotype consistent with a role for circulating IgM antibodies in apoptotic cell clearance. We have extensively characterised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c429ade0843452b05329460039cd8114
https://www.pure.ed.ac.uk/ws/files/20039397/Circulating_IgM_Requires_Plasma_Membrane_Disruption_to_Bind_Apoptotic_and_Non_Apoptotic_Nucleated_Cells_and_Erythrocytes.pdf
https://www.pure.ed.ac.uk/ws/files/20039397/Circulating_IgM_Requires_Plasma_Membrane_Disruption_to_Bind_Apoptotic_and_Non_Apoptotic_Nucleated_Cells_and_Erythrocytes.pdf
Autor:
Madeleine A. Vernon, Emily E. Hesketh, Bryan R. Conway, Jeremy Hughes, Spike Clay, Gary Borthwick, Peng Ding
Obstruction of the kidney may affect native or transplanted kidneys and results in kidney injury and scarring. Presented here is a model of obstructive nephropathy induced by unilateral ureteric obstruction (UUO), which can either be irreversible (UU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143013b6f929ce6bc55565153e4382ab
https://europepmc.org/articles/PMC4396952/
https://europepmc.org/articles/PMC4396952/
Publikováno v:
Journal of visualized experiments : JoVE. (92)
Rejection of the transplanted kidney in humans is still a major cause of morbidity and mortality. The mouse model of renal transplantation closely replicates both the technical and pathological processes that occur in human renal transplantation. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9babfb3ec12c52bb96f5415d1ed69885
https://pubmed.ncbi.nlm.nih.gov/25350513
https://pubmed.ncbi.nlm.nih.gov/25350513
Publikováno v:
Hesketh, E E, Kluth, D C & Hughes, J 2014, ' Apoptotic cell administration is detrimental in murine renal ischaemia reperfusion injury ', Journal of inflammation, vol. 11, no. 1, pp. 31 . https://doi.org/10.1186/s12950-014-0031-6
Journal of Inflammation (London, England)
Journal of Inflammation (London, England)
Background Acute kidney injury induced by renal ischaemia reperfusion injury (IRI) is characterised by renal failure, acute tubular necrosis (ATN), inflammation and microvascular congestion. The administration of apoptotic cells (ACs) has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79209c297a330c8f4f4927e24b5df968
https://hdl.handle.net/20.500.11820/a6525aa2-f138-4de5-9683-a55356705733
https://hdl.handle.net/20.500.11820/a6525aa2-f138-4de5-9683-a55356705733
Autor:
David A. Ferenbach, David C. Kluth, Michael Clay, Gary Borthwick, Jeremy Hughes, Emily E. Hesketh, Alicja Czopek
Publikováno v:
Journal of Visualized Experiments.
Renal ischaemia reperfusion injury (IRI) is a common cause of acute kidney injury (AKI) in patients and occlusion of renal blood flow is unavoidable during renal transplantation. Experimental models that accurately and reproducibly recapitulate renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231e6e9a0dfe1c5068a2cd4e6d81fec7
https://doi.org/10.3791/51816-v
https://doi.org/10.3791/51816-v
Autor:
Shona H. Wood, Emily E. Hesketh, Guang Hu, André Macedo, Georges E. Janssens, João Pedro de Magalhães, A. Sofia Silva, Michael Plank, George M. Church
Publikováno v:
Scientific Reports
Large-scale RNAi-based screens are a major technology, but require adequate prioritization and validation of candidate genes from the primary screen. In this work, we performed a large-scale pooled shRNA screen in mouse embryonic stem cells (ESCs) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9dbeed9519566f8f84499c5a284292
https://doi.org/10.1038/srep01076
https://doi.org/10.1038/srep01076