Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Emily Desormeaux"'
Autor:
Matthew P A, Henderson, Nathan, McIntosh, Amy, Chambers, Emily, Desormeaux, Michael, Kowalski, Jennifer, Milburn, Pranesh, Chakraborty
Publikováno v:
Clinical Biochemistry. 115:129-136
This study set out to examine pre-analytical factors affecting the frequency of positive results in newborn screening for biotinidase deficiency. This investigation was prompted by an increase in the annual screen positive rate for biotinidase defici
Publikováno v:
Chemical Science. 14:2537-2546
Expression of Glu-tRNA and its synthetase from lanthipeptide encoding bacteria using pEVOL improves production in E. coli. Often-observed glutathionylation can be reversed using LanCL enzymes.
Autor:
Jana Gomez, Jair L. Siqueira-Neto, Drake M. Mellott, Jorge Cruz-Reyes, Emily Desormeaux, Claudia Calvet Alvarez, Jean A. Bernatchez, Thomas D. Meek, Linfeng Li, Xiang Zhai, Elizabeth Alvarez Hernandez, Balachandra Chenna, James H. McKerrow
Publikováno v:
J Med Chem
Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaff
Publikováno v:
Biochemistry
Nucleoside analogues are among the most common medications given for the treatment of viral infections and cancers. The therapeutic effectiveness of nucleoside analogues can be dramatically improved by phosphorylation. The ProTide approach was develo
Autor:
Emily Desormeaux, Frank M. Raushel, Sue Y. Bae, Dao Feng Xiang, Andrew N. Bigley, Steven P. Harvey
Publikováno v:
Biochemistry. 58:2039-2053
The bacterial enzyme phosphotriesterase (PTE) is noted for its ability to hydrolyze many organophosphate compounds, including insecticides and chemical warfare agents. PTE has been the subject of multiple enzyme evolution attempts, which have been hi