Výsledky vyhledávání - "Emily D. Shaw"

Akademický článek

Tissue-Specific Vulnerability to Apoptosis in Machado-Joseph Disease

Autor: Ana F. Ferreira, Mafalda Raposo, Emily D. Shaw, Naila S. Ashraf, Filipa Medeiros, Maria de Fátima Brilhante, Matthew Perkins, João Vasconcelos, Teresa Kay, Maria do Carmo Costa, Manuela Lima

Publikováno v: Cells, Vol 12, Iss 10, p 1404 (2023)

Machado-Joseph disease (MJD) is a dominant neurodegenerative disease caused by an expanded CAG repeat in the ATXN3 gene encoding the ataxin-3 protein. Several cellular processes, including transcription and apoptosis, are disrupted in MJD. To gain fu

Externí odkaz: https://doaj.org/article/51ef8ef0de7c44ac94a738ec7270b90a

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Akademický článek

Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein

Autor: Naila S. Ashraf, Joanna R. Sutton, Yemen Yang, Bedri Ranxhi, Kozeta Libohova, Emily D. Shaw, Anna J. Barget, Sokol V. Todi, Henry L. Paulson, Maria do Carmo Costa

Publikováno v: Neurobiology of Disease, Vol 137, Iss , Pp 104697- (2020)

Spinocerebellar Ataxia type 3 (SCA3, also known as Machado-Joseph disease) is a neurodegenerative disorder caused by a CAG repeat expansion encoding an abnormally long polyglutamine (polyQ) tract in the disease protein, ataxin-3 (ATXN3). No preventiv

Externí odkaz: https://doaj.org/article/49b7e51b376e4f77940a1e4f5f69b412

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Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein

Autor: Maria do Carmo Costa, Joanna R. Sutton, Henry L. Paulson, Sokol V. Todi, Bedri Ranxhi, Anna J. Barget, Naila S. Ashraf, Yemen Yang, Kozeta Libohova, Emily D. Shaw

Publikováno v: Neurobiology of Disease, Vol 137, Iss, Pp 104697-(2020)

BackgroundSpinocerebellar Ataxia type 3 (SCA3, also known as Machado-Joseph disease) is a neurodegenerative disorder caused by a CAG repeat expansion encoding an abnormally long polyglutamine (polyQ) tract in the disease protein, ataxin-3 (ATXN3). No

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912907d217b890e7a57735cf6179a0af
https://pubmed.ncbi.nlm.nih.gov/31783119

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Citalopram reduces aggregation of ATXN3 in a YAC transgenic mouse model of Machado-Joseph disease

Autor: Sara Duarte-Silva, Maria do Carmo Costa, Naila S. Ashraf, Andreia Teixeira-Castro, Emily D. Shaw, Henry L. Paulson, Patrícia Maciel

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Mol Neurobiol

Machado-Joseph disease, also known as spinocerebellar ataxia type 3, is a fatal polyglutamine disease with no disease-modifying treatment. The selective serotonin reuptake inhibitor citalopram was shown in nematode and mouse models to be a compelling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff01f410f4e9a17cb4dfcda9420a4014

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