Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Emily Creger"'
Autor:
Steven Cha, Emily Creger, Betty Tam, Chi-Ching Mak, Brian Eastman, Lauren Sitts, Sunil Kc, Carine Bossard, Heekyung Chung, John Duc Nguyen, Timothy Phalen
Publikováno v:
Cancer Research. 80:P3-13
Aberrant activation of the Wnt signaling pathway is associated with tumorigenesis, relapse/chemoresistance, and distance metastasis in TNBC. SM08502 is a novel, oral, small-molecule pan-CLK inhibitor that has been shown to potently inhibit the Wnt si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e3e74cccc9b7148f68b7990b4e1e332
https://doi.org/10.1158/1538-7445.sabcs19-p3-13-01
https://doi.org/10.1158/1538-7445.sabcs19-p3-13-01
Autor:
Eric Wang, Jose Mario Bello Pineda, Won Jun Kim, Sisi Chen, Jessie Bourcier, Maximilian Stahl, Simon J. Hogg, Jan Phillipp Bewersdorf, Cuijuan Han, Michael E. Singer, Daniel Cui, Caroline E. Erickson, Steven M. Tittley, Alexander V. Penson, Katherine Knorr, Robert F. Stanley, Jahan Rahman, Gnana Krishnamoorthy, James A. Fagin, Emily Creger, Elizabeth McMillan, Chi-Ching Mak, Matthew Jarvis, Carine Bossard, Darrin M. Beaupre, Robert K. Bradley, Omar Abdel-Wahab
Publikováno v:
Cancer Cell. 41:164-180.e8
Therapy resistance is a major challenge in the treatment of cancer. Here, we performed CRISPR-Cas9 screens across a broad range of therapies used in acute myeloid leukemia to identify genomic determinants of drug response. Our screens uncover a selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fc537c2ce087e5c5ed1cc59d902cbb
https://doi.org/10.1016/j.ccell.2022.12.002
https://doi.org/10.1016/j.ccell.2022.12.002
Autor:
Elizabeth A. McMillan, Carine Bossard, Emily Creger, Carsten Merkwirth, Raffaella Pippa, Matthew Jarvis, Krishna Sriram, Melinda Pedraza, Maureen Ibanez, Deepti Bhat, Carolyn Lai, Josh Stewart, Brian Eastman, Chi-Ching Mak, Michael A. White, Darrin Beaupre
Publikováno v:
Cancer Research. 82:3928-3928
Dysregulated alternative pre-mRNA splicing (AS) is commonly associated with human malignancies, producing pathological proteomes that underlie disease initiation, progression, and therapeutic resistance. The CDC2-like kinases (CLKs) and dual-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e46f4bcd59e8ede8c3333479cae32f5
https://doi.org/10.1158/1538-7445.am2022-3928
https://doi.org/10.1158/1538-7445.am2022-3928
Autor:
Elizabeth A. McMillan, Krishna Sriram, Emily Creger, Carsten Merkwirth, Raffaella Pippa, Melinda Pedraza, Long Do, Vishal Deshmukh, Carine Bossard, Michael A. White
Publikováno v:
Molecular Cancer Therapeutics. 20:P231-P231
Alternative pre-mRNA splicing (AS) supports the dynamic and regulated diversification of cells by allowing the production of multiple distinct proteins from individual genes. Dysregulated AS is commonly associated with human malignancies, producing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c027a791a117033804ef5f5b4f56b3
https://doi.org/10.1158/1535-7163.targ-21-p231
https://doi.org/10.1158/1535-7163.targ-21-p231
Autor:
Carine Bossard, Emily Creger, Elizabeth A. McMillan, Carsten Merkwirth, Maureen Ibanez, Deepti Bhat, Josh Stewart, Brian Eastman, Chi-Ching Mak, Vishal Deshmukh, Michael A. White
Publikováno v:
Molecular Cancer Therapeutics. 20:P242-P242
A monumental challenge facing cancer therapy is the vast mechanistic diversity of tumors among and even within cancer patients. This severely limits the number of patients that respond to any given therapy and the durability of responses that do occu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f94f5e145f18607c0a4b5a493360edc1
https://doi.org/10.1158/1535-7163.targ-21-p242
https://doi.org/10.1158/1535-7163.targ-21-p242
Autor:
Emily Creger, Chi-Ching Mak, Michael A. White, Elizabeth A. McMillan, Darrin M. Beaupre, Carine Bossard, Brian Eastman
Publikováno v:
Blood. 138:2950-2950
Mutations in spliceosomal genes are one of the most common classes of somatic alterations in patients with Myelodysplastic Syndrome (MDS) and occur across the entire spectrum of myeloid malignancies, including 10‒25% of patients with acute myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af3121d330da50042c1ef0a2cedd268
https://doi.org/10.1182/blood-2021-151305
https://doi.org/10.1182/blood-2021-151305
Autor:
Yusuf Yazici, Abdullah Ghias, Joseph Cahiwat, Dellamary Luis A, Charlene F. Barroga, John Duc Nguyen, V. Deshmukh, Emily Creger, Maureen Ibanez, Chiao-Wen Chen, Heekyung Chung, Betty Tam, Sunil Kumar Kc, Kevin Chiu, Steven Cha, Long Do, Timothy Phalen, Shawn Cho, Jackie Nguyen, Josh Stewart, Brian Eastman, Carine Bossard, John Hood, Chi Ching Mak
Publikováno v:
Cancer letters. 473
The Wnt/β-catenin signaling pathway is aberrantly activated in colorectal (CRC) and many other cancers, and novel strategies for effectively targeting it may be needed due to its complexity. In this report, SM08502, a novel small molecule in clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de45353235eba4fb043ec230a848ce36
https://pubmed.ncbi.nlm.nih.gov/31560935
https://pubmed.ncbi.nlm.nih.gov/31560935
Autor:
Sunil Kc, Emily Creger, Lauren Sitts, Timothy Phalen, Betty Tam, Gail Bucci, Carine Bossard, Heekyung Chung, Erica Liao, Steven Cha, Josh Stewart, Brian Eastman, Chi-Ching Mak
Publikováno v:
Clinical Cancer Research. 26:A09-A09
Aberrant activation of the Wnt signaling pathway is observed in ovarian cancer (OC) and is associated with chemoresistance, immune evasion, and poor prognosis. SM08502 is a novel, oral, small-molecule pan-CLK inhibitor that has been shown to potently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c4c34543dbe289ead36348f44e3a5f5
https://doi.org/10.1158/1557-3265.ovca19-a09
https://doi.org/10.1158/1557-3265.ovca19-a09
Autor:
Lauren Sitts, Steven Cha, Kevin Chiu, Chi-Ching Mak, Timothy Phalen, Heekyung Chung, Gail Bucci, Emily Creger, Betty Tam, Sunil Kc, Josh Stewart
Publikováno v:
Blood. 134:4059-4059
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma (NHL) that accounts for ~7% of all NHL in the U.S. MCL is associated with aberrant activation of the Wnt signaling pathway, which plays a key role in the survival and maintenance of MCL-init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb3210974dc8279b6edd12520bb3d935
https://doi.org/10.1182/blood-2019-124812
https://doi.org/10.1182/blood-2019-124812
Autor:
Chi-Ching Mak, Timothy Phalen, Sunil Kc, Lauren Sitts, Emily Creger, Kevin Chiu, Betty Tam, Steven Cha, Gail Bucci, Heekyung Chung, Josh Stewart
Publikováno v:
Blood. 134:3913-3913
Acute myeloid leukemia (AML) with TP53 mutation makes up ~13% of AML cases and is an aggressive, treatment-resistant subtype with dismal prognosis and limited therapeutic options. Aberrant activation of the Wnt signaling pathway is associated with AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c463616ba8c3300eed5431136088641
https://doi.org/10.1182/blood-2019-131209
https://doi.org/10.1182/blood-2019-131209