350 Enhancing directly selected tumor-reactive TIL function through genetic modification

Autor: Christophe Pedros, Emily Carron, Larissa Pikor, Barbara Sennino, Sowbarnika Ratliff, April Fraley, Justin Rahman, Niloufar Khojandi, Bryant Thompson, Mathew Thayer

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/e8ff8bd80b984ca0b04dd1886712491e

Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies

Autor: Bruno Sainz, Emily Carron, Mireia Vallespinós, Heather L. Machado

Publikováno v: Mediators of Inflammation, Vol 2016 (2016)

Cancer stem cells (CSCs) are a unique subset of cells within tumors with stemlike properties that have been proposed to be key drivers of tumor initiation and progression. CSCs are functionally defined by their unlimited self-renewal capacity and the

Externí odkaz: https://doaj.org/article/e95312ed9411440bb9c5bf2628079860

138 Synthetic re-direction of TGFβ receptors as a novel strategy to enhance the anti-tumor activity of CAR-T cells in solid tumors

Autor: Eigen Peralta, Kenyon Lyon, Thomas H. Lee, Yijia Pan, Arvin Tam, Alec Witty, Mochtar Pribadi, Hui-yi Chu, Emily Carron, Natalie Navarrete, Bob Valamehr, Amit R. Mehta, Philip Chu, Dan Lu, Lorraine Loter

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundTransforming growth factor beta (TGFβ) is an immuno-suppressive cytokine present in the tumor microenvironment (TME) that creates considerable challenges for the treatment of solid tumors. Small molecule inhibitors targeting TGFβ exist, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf21463b83649abbdab73fc26d19bd3
https://doi.org/10.1136/jitc-2021-sitc2021.138

Novel Method for Clonal Selection of Multiplexed Engineered CAR-T Cells Which Uniquely Demonstrate Anti-Tumor Functionality in the Tumor Microenvironment

Autor: Joyee Yao, Thomas H. Lee, Dan Lu, Sandeep Kothapally Hanok, Daniel Shoemaker, Jason ORourke, Yinghui Sui, Natalie Navarrete, Matthew Denholtz, Bahram Valamehr, David J. Robbins, Eigen Peralta, Angela Gentile, Emily Carron, Cokey Nguyen, Eric Sung

Publikováno v: Blood. 136:12-12

Despite the success of chimeric antigen receptor (CAR)-T cell therapy in various hematologic malignancies, obstacles to an effective therapeutic outcome are highly dependent on the tumor type being targeted and the immune microenvironment that the CA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dc68ae3b22a55ab2d006ecf179a5f66
https://doi.org/10.1182/blood-2020-141506

Cancer stem cells and macrophages: implications in tumor biology and therapeutic strategies

Autor: Mireia Vallespinós, Emily Carron, Heather L. Machado, Bruno Sainz

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Mediators of Inflammation
Biblos-e Archivo. Repositorio Institucional de la UAM
Mediators of Inflammation, Vol 2016 (2016)

Cancer stem cells (CSCs) are a unique subset of cells within tumors with stemlike properties that have been proposed to be key drivers of tumor initiation and progression. CSCs are functionally defined by their unlimited self-renewal capacity and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17d05d0f0fe174f8e90899afa0421cc
http://hdl.handle.net/10261/151193