Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Emily C. Hartman"'
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Akademický článek
Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle
Autor: Emily C. Hartman, Christopher M. Jakobson, Andrew H. Favor, Marco J. Lobba, Ester Álvarez-Benedicto, Matthew B. Francis, Danielle Tullman-Ercek
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Self-assembling proteins have important applications in industrial technologies, but it is difficult to predict how mutations affect assembly. Here the authors present SyMAPS, coupling comprehensive codon mutagenesis with high-throughput sequencing,
Externí odkaz: https://doaj.org/article/32650acf858e4272b1227a70f3e4f8ee
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2
Data from A Small Molecule That Binds and Inhibits the ETV1 Transcription Factor Oncoprotein
Autor: Levi A. Garraway, Angela N. Koehler, Lucienne Ronco, Raymond Pagliarini, Douglas S. Daniels, Fallon Lin, Elizabeth K. Culyba, Cheng Zhong, Timothy A. Lewis, Emily C. Hartman, Jean-Philippe Theurillat, Colin W. Garvie, Nicolas Stransky, Marius S. Pop
Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1 (ETV1) is an ETS factor gene that undergoes chromosomal translocation in prostate cancers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b7be6ddfbcc316a35352a8de524552
https://doi.org/10.1158/1535-7163.c.6536437
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5
Grassroots Efforts To Quantify and Improve the Academic Climate of an R1 STEM Department: Using Evidence-Based Discussions To Foster Community
Autor: David E. Wemmer, Emily C. Hartman, Christiane N. Stachl, Matthew B. Francis
Publikováno v: Journal of Chemical Education. 96:2149-2157
Women and some racial and ethnic groups remain underrepresented in chemistry departments across the United States, and generally, efforts to improve representation have resulted in minimal or no improvements in the last 10 years. Here, we present the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba44f6efe9f3955da37e56453a76013
https://doi.org/10.1021/acs.jchemed.9b00163
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6
Learning from protein fitness landscapes: a review of mutability, epistasis, and evolution
Autor: Danielle Tullman-Ercek, Emily C. Hartman
Publikováno v: Current Opinion in Systems Biology. 14:25-31
Proteins carry out many diverse functions in nature and are increasingly used in non-native contexts, such as in medical or industrial applications. A wide array of synthetic biology techniques can be used both to study proteins in their native conte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94feb598cb958e8e3bcd3baf1531ccea
https://doi.org/10.1016/j.coisb.2019.02.006
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7
Engineering a virus-like particle to display peptide insertions using an apparent fitness landscape
Autor: Bon Ikwuagwu, Matthew B. Francis, Stephanie A. Robinson, Danielle Tullman-Ercek, Emily C. Hartman
Publikováno v: Biomacromolecules
Biomacromolecules, vol 21, iss 10
Peptide insertions in the primary sequence of proteins expand functionality by introducing new binding sequences, chemical handles, or membrane disrupting motifs. With these properties, proteins can be engineered as scaffolds for vaccines or targeted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91aeba00b2966e68716b4d3c8cba833
https://europepmc.org/articles/PMC7959485/
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8
Experimental Evaluation of Coevolution in a Self-Assembling Particle
Autor: Stephanie A. Robinson, Emily C. Hartman, Marco J. Lobba, Andrew H. Favor, Matthew B. Francis, Danielle Tullman-Ercek
Publikováno v: Biochemistry. 58:1527-1538
Protein evolution occurs via restricted evolutionary paths that are influenced by both previous and subsequent mutations. This effect, termed epistasis, is critical in population genetics, drug resistance, and immune escape; however, the effect of ep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94c20e9e44bd618d74a18ead1af8fc1
https://doi.org/10.1021/acs.biochem.8b00948
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9
Systematic Engineering of a Protein Nanocage for High-Yield, Site-Specific Modification
Autor: Daniel L V Bader, Daniel D. Brauer, Emily C. Hartman, Zoe N Merz, Danielle Tullman-Ercek, Matthew B. Francis
Publikováno v: Journal of the American Chemical Society. 141(9)
Site-specific protein modification is a widely used strategy to attach drugs, imaging agents, or other useful small molecules to protein carriers. N-terminal modification is particularly useful as a high-yielding, site-selective modification strategy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c08c0b3ba11ac33e6e8677554913c96
https://pubmed.ncbi.nlm.nih.gov/30730722
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10
A Selection for Assembly Reveals That a Single Amino Acid Mutant of the Bacteriophage MS2 Coat Protein Forms a Smaller Virus-like Particle
Autor: Norma M. Morella, Emily C. Hartman, Danielle Tullman-Ercek, Michael A. Asensio, Peter H. Zwart, Christopher M. Jakobson, Banumathi Sankaran, Jeff E. Glasgow
Publikováno v: Nano letters, vol 16, iss 9
Asensio, MA; Morella, NM; Jakobson, CM; Hartman, EC; Glasgow, JE; Sankaran, B; et al.(2016). A Selection for Assembly Reveals That a Single Amino Acid Mutant of the Bacteriophage MS2 Coat Protein Forms a Smaller Virus-like Particle. Nano Letters, 16(9), 5944-5950. doi: 10.1021/acs.nanolett.6b02948. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/0hh6m30h
© 2016 American Chemical Society. Virus-like particles are used to encapsulate drugs, imaging agents, enzymes, and other biologically active molecules in order to enhance their function. However, the size of most virus-like particles is inflexible,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd19635cf15df35c43bfc4664e2af72
https://doi.org/10.1021/acs.nanolett.6b02948
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