Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Emily C. D'Amato"'
Autor:
Rachel M Dick, Mark E. Gurney, Lester S Manly, Victor W. Pike, Sami S. Zoghbi, Nugent Richard, Janice A. Sindac, Jinsoo Hong, Jeih San Liow, Cheryl L. Morse, Emily C. D’Amato, Robert B. Innis, Xuesheng Mo, Sanjay Telu, Robert L. Gladding, Yuichi Wakabayashi, Brian E. Marron, Masahiro Fujita, Maarten Ooms
Publikováno v:
ACS Chem Neurosci
We aimed to develop radioligands for PET imaging of brain phosphodiesterase subtype 4D (PDE4D), a potential target for developing cognition enhancing or anti-depressive drugs. Exploration of several chemical series gave four leads with high PDE4D inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be97eda4c5f7f24c27268d008983b6e4
https://europepmc.org/articles/PMC7444660/
https://europepmc.org/articles/PMC7444660/
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 12(1)
Between 20% and 25% of patients diagnosed with Alzheimer's disease (AD) do not have amyloid burden as assessed by positron emission tomography imaging. Thus, there is a need for nonamyloid-directed therapies for AD, especially for those patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39412fc3e908d66de3a385ec70ff137c
https://pubmed.ncbi.nlm.nih.gov/25371167
https://pubmed.ncbi.nlm.nih.gov/25371167
