Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Emily B. Askew"'
Publikováno v:
The FASEB Journal. 36
Autor:
Saho Tsuchiya, Shinya Ishizuka, Yoshifumi Ohashi, Kenya Terabe, Emily B. Askew, Cheryl B. Knudson, Naoko Ishizuka, Warren Knudson
Publikováno v:
J Biol Chem
Osteoarthritis (OA) is a progressive degenerative disease of the joints caused in part by a change in the phenotype of resident chondrocytes within affected joints. This altered phenotype, often termed proinflammatory or procatabolic, features enhanc
Publikováno v:
Matrix Biol
The story of hyaluronan in articular cartilage, pericellular hyaluronan in particular, essentially is also the story of aggrecan. Without properly tethered aggrecan, the load bearing function of cartilage is compromised. The anchorage of aggrecan to
Autor:
Emily B. Askew, Cheryl B. Knudson, Nobunori Takahashi, Michelle Cobb, Warren Knudson, Kenya Terabe
Publikováno v:
Archives of Biochemistry and Biophysics. 665:1-11
In this study we examined whether the action of simvastatin affects re-differentiation of passaged chondrocytes and if so, whether this was mediated via changes in cholesterol or cholesterol intermediates. Bovine articular chondrocytes, of varying pa
Publikováno v:
The FASEB Journal. 33
Autor:
Emily B. Askew, Kelly M. Harrell
Publikováno v:
The FASEB Journal. 34:1-1
Androgen receptor (AR) transcriptional activity depends on interactions between the AR NH2-terminal region and transcriptional coregulators. A yeast two-hybrid screen of a human testis library using predicted α-helical NH2-terminal fragment AR-(370
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c65874507bb9eb91faa72577a13628
Publikováno v:
Arthritis & Rheumatology. 66:1547-1558
Objective Cell–matrix interactions promote cartilage homeostasis. We previously found that Smad1, the transcriptional modulator of the canonical bone morphogenetic protein 7 (BMP-7) pathway, interacted with the cytoplasmic domain of CD44, the princ
Publikováno v:
Journal of Biological Chemistry. 288:25838-25850
The hyaluronan receptor CD44 undergoes sequential proteolytic cleavage at the cell surface. The initial cleavage of the CD44 extracellular domain is followed by a second intramembranous cleavage of the residual CD44 fragment, liberating the C-termina
Depletion of the cartilage proteoglycan aggrecan is one of the earliest events that occurs in association with osteoarthritis. This loss is often accompanied by a coordinate loss in another glycosaminoglycan, hyaluronan. Chondrocytes experimentally d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43343c68d4d567fd9e664ebed5d699ee
https://europepmc.org/articles/PMC4933260/
https://europepmc.org/articles/PMC4933260/