Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Emily A. Rue"'
Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease
Autor:
Gregory J. Heller, Duc Nguyen, Stephanie M. Cologna, Koralege C. Pathmasiri, Stephen J. Crocker, Jeffrey N. Marshall, Michael S. Marshall, Emily A. Rue, Richard B. van Breemen, Leon M. Tai, Ernesto R. Bongarzone, Yazan Issa, Mark S. Sands, Miriam S. Domowicz, Maria I. Givogri
Publikováno v:
Mol Ther
Neonatal AAV9-gene therapy of the lysosomal enzyme galactosylceramidase (GALC) significantly ameliorates central and peripheral neuropathology, prolongs survival, and largely normalizes motor deficits in Twitcher mice. Despite these therapeutic miles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc739ce92eba6d5ef19db8596740742f
https://doi.org/10.1016/j.ymthe.2021.01.026
https://doi.org/10.1016/j.ymthe.2021.01.026
Autor:
Jan A. Gliński, Michael D. Rush, Paul J. Kowalski, Emily A. Rue, Alan Wong, Richard B. van Breemen
Publikováno v:
Journal of Agricultural and Food Chemistry. 66:11355-11361
Although procyanidins constitute a unique class of polymeric plant secondary metabolites with a variety of biological properties including potent antioxidant activity, structure determination has been challenging, and structures of many complex procy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf549c1c61a6fd3181b46b306ba543a
https://doi.org/10.1021/acs.jafc.8b04258
https://doi.org/10.1021/acs.jafc.8b04258
Autor:
Ernesto R. Bongarzone, Richard B. van Breemen, Vince Elackattu, Benas Jakubauskas, Yazan Issa, Subha Karumuthil-Melethil, Maarten C. Bosland, Stephen J. Crocker, Duc Nguyen, Zane Hauck, Jeffrey N. Marshall, Violeta Zaric, Emily A. Rue, Monika Stoskute, Michael S. Marshall, Wil Bogue, Steven J. Gray, Maria I. Givogri
Publikováno v:
Molecular Therapy. 26:874-889
We report a global adeno-associated virus (AAV)9-based gene therapy protocol to deliver therapeutic galactosylceramidase (GALC), a lysosomal enzyme that is deficient in Krabbe’s disease. When globally administered via intrathecal, intracranial, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edec13ad7ad40c3b4dbd9115562bc25
https://doi.org/10.1016/j.ymthe.2018.01.009
https://doi.org/10.1016/j.ymthe.2018.01.009
Publikováno v:
Phytochemistry Reviews. 17:1-16
Procyanidins are polyphenols abundant in dietary fruits, vegetables, nuts, legumes, and grains with a variety of chemopreventive biological effects. Rapid structure determination of these compounds is needed, notably for the more complex polymeric pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54762d3d9a0b4886f2f1cbd21f39780b
https://doi.org/10.1007/s11101-017-9507-3
https://doi.org/10.1007/s11101-017-9507-3
Publikováno v:
J Mass Spectrom
Procyanidins are polymeric flavan-3-ones occurring in many plants with antioxidant and other beneficial bioactivities. They are composed of catechin and epicatechin monomeric units connected by single carbon-carbon B-type linkages or A-type linkages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf729d4558b8e8d57fe544c42697987
https://pubmed.ncbi.nlm.nih.gov/31144405
https://pubmed.ncbi.nlm.nih.gov/31144405
Autor:
Shuai Wang, RS Phansalkar, Caitlin E. Howell, Birgit M. Dietz, Obinna Mbachu, Guido F. Pauli, Shao-Nong Chen, Judy L. Bolton, Emily A. Rue, Tareisha L. Dunlap
Publikováno v:
Chemical Research in Toxicology
Humulus lupulus L. (hops) is a popular botanical dietary supplement used by women as a sleep aid and for postmenopausal symptom relief. In addition to its efficacy for menopausal symptoms, hops can also modulate the chemical estrogen carcinogenesis p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c7fbabf75c82b2d6b334616b34aa0b
http://europepmc.org/articles/PMC4951797
http://europepmc.org/articles/PMC4951797
Autor:
Ernesto R. Bongarzone, Marta B. Santos, Vadim Gaponenko, Giuseppe Scesa, Michael S. Marshall, Maria Soledad Celej, Richard B. van Breemen, Duc Nguyen, Jeffrey N. Marshall, Zane Hauck, Rachael A. Smith, Vince Elackattu, Monika Stoskute, Yazan Issa, Emily A. Rue, Hazem Abdelkarim
Publikováno v:
Scientific Reports
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 8, Iss 1, Pp 1-19 (2018)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports, Vol 8, Iss 1, Pp 1-19 (2018)
Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson´s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosphingolipids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a88a805f3fde154e9209b6006231535
https://pubmed.ncbi.nlm.nih.gov/30127535
https://pubmed.ncbi.nlm.nih.gov/30127535
Publikováno v:
International journal of offender therapy and comparative criminology. 62(3)
The use of home visits has a long and storied history in the United States from different disciplines, such as nursing, prenatal mothers, young families, health promotion, and community corrections. Ecological theory explains how formal actors play a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9e62f9ff3e614799ba1d5ae943e7a1
https://pubmed.ncbi.nlm.nih.gov/27272525
https://pubmed.ncbi.nlm.nih.gov/27272525
Autor:
Benas Jakubauskas, Michael S. Marshall, Zane Hauck, Lisa DiAntonio, Richard B. van Breemen, Wil Bogue, Monika Stoskute, Ernesto R. Bongarzone, Emily A. Rue, Matthew Nichols, Carlos A. Saavedra-Matiz, Jeffrey H. Kordower
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193438 (2018)
PLoS ONE
PLoS ONE
α-Synuclein aggregation has been linked to Gaucher’s disease (GD) and Krabbe’s disease (KD), lysosomal conditions affecting glycosphingolipid metabolism. α-Synuclein pathology has been directly attributed to the dysregulation of glycosphingolip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805974d29dedc67ab7521612c61628da
https://doi.org/10.1371/journal.pone.0193438
https://doi.org/10.1371/journal.pone.0193438
Publikováno v:
SPIE Proceedings.
A new four channel continuous wave near IR spectroscopy instrument for regional cerebral oxygenation monitoring has been developed. The instrument uses laser diodes to transmit pulses of near IR light at wavelengths of 775, 845 and 904 nm. The instru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c2551f844e187bf72f4f4fbaefc4b3
https://doi.org/10.1117/12.384905
https://doi.org/10.1117/12.384905