Výsledky vyhledávání - "Emily A. Kawaler"

Akademický článek

Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Abstract The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking.

Externí odkaz: https://doaj.org/article/3a27bc68fbda40dca2027e7c95c28684

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Akademický článek

Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting

Autor: Jessica N. Everett, Shenin A. Dettwyler, Xiaohong Jing, Cody Stender, Madeleine Schmitter, Ariele Baptiste, Jennifer Chun, Emily A. Kawaler, Lauren G. Khanna, Seth A. Gross, Tamas A. Gonda, Nina Beri, Paul E. Oberstein, Diane M. Simeone

Publikováno v: Cancer Medicine, Vol 12, Iss 3, Pp 2345-2355 (2023)

Abstract Background Genetic testing is recommended for all pancreatic ductal adenocarcinoma (PDAC) patients. Prior research demonstrates that multidisciplinary pancreatic cancer clinics (MDPCs) improve treatment‐ and survival‐related outcomes for

Externí odkaz: https://doaj.org/article/0f6a7df4ed6f4128a0db53d3b8d92eac

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Akademický článek

Author Correction: Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Externí odkaz: https://doaj.org/article/fbf64e220d324d00ad2d20768841c89d

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The role of CTNNB1 mutations and matrix metalloproteinases (MMPs) in anti-angiogenesis treatment of endometrial carcinoma

Autor: Amnon A, Berger, Emily A, Kawaler, Fanny, Dao, Selim, Misirlioglu, Ernesto Arostegui, Fernandez, Narciso, Olvera, Elke, Van Oudenhove, Deborah, DeLair, Douglas A, Levine

Publikováno v: Gynecologic Oncology. 167:323-333

Treatment options and associated biomarkers for advanced and recurrent disease are limited. Endometrial cancers (ECs) with CTNNB1 exon 3 mutations appear to have preferential response to bevacizumab, an anti-angiogenesis treatment, though the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6800b3eb5f548851801f898bb14b766
https://doi.org/10.1016/j.ygyno.2022.09.013

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Impact of comprehensive family history and genetic analysis in the multidisciplinary pancreatic tumor clinic setting

Publikováno v: Cancer Medicine. 12:2345-2355

Genetic testing is recommended for all pancreatic ductal adenocarcinoma (PDAC) patients. Prior research demonstrates that multidisciplinary pancreatic cancer clinics (MDPCs) improve treatment- and survival-related outcomes for PDAC patients. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3d99d3c25c6b152b9b5029d488e9b1
https://doi.org/10.1002/cam4.5059

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Single-Cell RNA Sequencing Reveals the Effects of Chemotherapy on Human Pancreatic Adenocarcinoma and its Tumor Microenvironment

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking. We perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::002a94d438cf46197effb2a545cbd62e
https://doi.org/10.1101/2022.05.24.493132

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Abstract PR005: Primary results of PanCAN-SR1, a phase 1b study evaluating Gemcitabine, nab-Paclitaxel, Canakinumab, and Spartalizumab to target IL-1β and PD-1 in metastatic pancreatic cancer with correlative tissue and blood biomarker analysis

Autor: Paul E. Oberstein, Osama Rahma, Nina Beri, Amy Stoll-D'Astice, Emily A. Kawaler, Igor Dolgalev, Gregor Werba, Victoire Cardo-Ruffino, Naïma Böllenrücher, Andressa Dias Costa, Saloney Nazeer, Matthew Squires, Jonathan Nowak, Dafna Bar-Sagi, Brian Wolpin, Diane M Simeone, Stephanie K Dougan

Publikováno v: Cancer Research. 82:PR005-PR005

In preclinical work, the inflammatory cytokine IL-1β was shown to be upregulated in pancreatic cancer tumors and to contribute to activation of pancreatic stellate cells and immunosuppression (Das et al 2020). We conducted an open-label multicenter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58104e99d888c89fd24562dc3b984d47
https://doi.org/10.1158/1538-7445.panca22-pr005

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Abstract B065: Polymerase theta inhibition activates the cGAS-STING signaling pathway and elicits an immune response in homologous recombination-deficient pancreatic adenocarcinoma

Autor: Grace Oh, Annie Wang, Lidong Wang, Jiufeng Li, Gregor Werba, Daniel Weissinger, Ende Zhao, Surajit Dhara, Rosmel Hernandez, Amanda Ackermann, Despoina Kalfakakou, Emily A. Kawaler, Talia Golan, Theodore H. Welling, Agnel Sfeir, Diane M. Simeone

Publikováno v: Cancer Research. 82:B065-B065

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination (HR) repair genes in up to 25% of cases. Defects in HR impart to tumor cells a specific vulnerability to poly-ADP ribose polymera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d516c996ed5ab1ffd2244f3a550c2f39
https://doi.org/10.1158/1538-7445.panca22-b065

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Abstract PR010: Single-cell sequencing elucidates the effects of chemotherapy on cancer cell heterogeneity and the tumor microenvironment of human pancreatic adenocarcinoma

Publikováno v: Cancer Research. 82:PR010-PR010

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression. Improving our understanding of the PDAC TME and its role in response to therapy via in-depth single cell characterizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f23e514f039285a2bd5f06ca91a8ae2d
https://doi.org/10.1158/1538-7445.panca22-pr010

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