Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Emily A. Gaman"'
Autor:
Gordon J. Lithgow, Pedro Reis-Rodrigues, Uday S. Evani, Maithili C. Vantipalli, Bradford W. Gibson, Gregg Czerwieniec, Theodore W. Peters, Sean D. Mooney, Emily A. Gaman, Silvestre Alavez, Robert E. Hughes
Publikováno v:
Aging Cell
Summary While it is generally recognized that misfolding of specific proteins can cause late-onset disease, the contribution of protein aggregation to the normal aging process is less well understood. To address this issue, a mass spectrometry-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d51f210397f6430c71a17f0c660cfbb
https://doi.org/10.1111/j.1474-9726.2011.00765.x
https://doi.org/10.1111/j.1474-9726.2011.00765.x
Autor:
Karthik Venkatakrishnan, Emily A. Gaman, R. Scott Obach, Larry M. Tremaine, J. Brian Houston, Robert L. Walsky
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 316:336-348
The accuracy of in vitro inhibition parameters in scaling to in vivo drug-drug interactions (DDI) was examined for over 40 drugs using seven human P450-selective marker activities in pooled human liver microsomes. These data were combined with other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069ad42cf03cb8e44b12052b225a142a
https://doi.org/10.1124/jpet.105.093229
https://doi.org/10.1124/jpet.105.093229
Publikováno v:
The Journal of Clinical Pharmacology. 45:68-78
Cytochrome P450 2C8 is involved in the metabolism of drugs such as paclitaxel, repaglinide, rosiglitazone, and cerivastatin, among others. An in vitro assessment of 209 frequently prescribed drugs and related xenobiotics was carried out to examine th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4c07e0ae8a203bfd53c2180217a92e
https://doi.org/10.1177/0091270004270642
https://doi.org/10.1177/0091270004270642
Autor:
Wu-Min Deng, Stefan Baumgartner, Richard L. Frock, Martina Schneider, Hannele Ruohola-Baker, Casimiro Castillejo-López, Emily Anne Gaman
Publikováno v:
Development. 130:173-184
The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. Dystroglycan is a receptor for multiple extracellular matrix (EC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ea67a5ec9e10f3bd6da6174f4b23d7
https://doi.org/10.1242/dev.00199
https://doi.org/10.1242/dev.00199
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(3)
The leukotriene receptor antagonist montelukast was examined for its inhibition of the human drug-metabolizing enzyme cytochrome P4502C8 (CYP2C8). Montelukast was demonstrated to be a potent inhibitor of CYP2C8-catalyzed amodiaquine N-deethylase, ros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c925f0841a2f24b12a1af7b77b4cf2
https://pubmed.ncbi.nlm.nih.gov/15608135
https://pubmed.ncbi.nlm.nih.gov/15608135