New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story

Autor: Emily A. Dickie, Federica Giordani, Matthew K. Gould, Pascal Mäser, Christian Burri, Jeremy C. Mottram, Srinivasa P. S. Rao, Michael P. Barrett

Publikováno v: Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 29 (2020)

The twentieth century ended with human African trypanosomiasis (HAT) epidemics raging across many parts of Africa. Resistance to existing drugs was emerging, and many programs aiming to contain the disease had ground to a halt, given previous success

Externí odkaz: https://doaj.org/article/fcec70764b7842eda3b0f5326af38879

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition.

Autor: Pieter C Steketee, Emily A Dickie, James Iremonger, Kathryn Crouch, Edith Paxton, Siddharth Jayaraman, Omar A Alfituri, Georgina Awuah-Mensah, Ryan Ritchie, Achim Schnaufer, Tim Rowan, Harry P de Koning, Catarina Gadelha, Bill Wickstead, Michael P Barrett, Liam J Morrison

Publikováno v: PLoS Pathogens, Vol 17, Iss 7, p e1009734 (2021)

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit

Externí odkaz: https://doaj.org/article/d876db67785745d3836a0959a9e3e077

Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response

Autor: Edubiel A. Alpizar-Sosa, Nur Raihana Binti Ithnin, Wenbin Wei, Andrew W. Pountain, Stefan K. Weidt, Anne M. Donachie, Ryan Ritchie, Emily A. Dickie, Richard J. S. Burchmore, Paul W. Denny, Michael P. Barrett

Publikováno v: PLOS Neglected Tropical Diseases, 2022, Vol.16(9), pp.e0010779 [Peer Reviewed Journal]

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211f168830cff69dc45cb173585a9956
http://dro.dur.ac.uk/37233/

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition

Autor: Siddharth Jayaraman, Edith Paxton, Harry P. de Koning, Kathryn Crouch, Omar A. Alfituri, Pieter C. Steketee, Catarina Gadelha, Ryan Ritchie, Emily A. Dickie, Michael P. Barrett, Achim Schnaufer, Bill Wickstead, T.G Rowan, Liam J. Morrison, Georgina Awuah-Mensah, James Iremonger

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 7, p e1009734 (2021)
Steketee, P, Dickie, E A, Iremonger, J, Crouch, K, Paxton, E, Jayaraman, S, Alfituri, O, Awuah-Mensah, G, Ritchie, R, Schnaufer, A, Rowan, T, De Koning, H P, Gadelha, C, Wickstead, B, Barrett, M P & Morrison, L 2021, ' Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition ', PLoS Pathogens, vol. 17, no. 7, e1009734 . https://doi.org/10.1371/journal.ppat.1009734

Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major paucit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09479fd9ae271c20c8eba737e0d0d06b
http://europepmc.org/articles/PMC8384185

Antileishmanial chemotherapy through clemastine fumarate mediated inhibition of the Leishmania inositol phosphorylceramide synthase

Autor: John G. Mina, Emily A. Dickie, Edubiel A. Alpizar-Sosa, Paul W. Denny, Chris Brown, Maria Paula Gonçalves Borsodi, Cláudia P. Figueiredo, Wenbin Wei, Robson Coutinho-Silva, Douglas O. Escrivani, Emanuelle V. de Lima, Bartira Rossi-Bergmann, Andy Merritt, Amjed Qays Al-Qaisi, Patrick G. Steel, Michael P. Barrett, Rebecca L Charlton, Terry K. Smith

Publikováno v: ACS infectious diseases, 2021, Vol.7(1), pp.47-63 [Peer Reviewed Journal]

We thank CNPq (PVE Grant: 400894/2014-9 to B.R.-B. and P.G.S.), The Royal Society (The Royal Society International Collaboration Awards for Research Professors 2016: IC160044 to B.R.-B. and P.G.S.), MRC (iCASE studentship for C.B.; Grant MR/M020118/1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68269bc68eb5c08c88f7c95185bf53a9
https://hdl.handle.net/10023/21321