Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Emily A Witham"'
Autor:
Emily A. Witham, Shadi Shojaei, Emily V. Ho, Varykina G. Thackray, Stephanie C Bohaczuk, Genevieve E. Ryan, Jessica Cassin, Pamela L. Mellon
Publikováno v:
Mol Cell Endocrinol
Within pituitary gonadotropes, the gonadotropin-releasing hormone receptor (GnRHR) receives hypothalamic input from GnRH neurons that is critical for reproduction. Previous studies have suggested that androgens may regulate GnRHR, although the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23cf8db753ddbdc18e66f183ee4c93d0
https://escholarship.org/uc/item/62r6231t
https://escholarship.org/uc/item/62r6231t
Kisspeptin Regulates Gonadotropin Genes via Immediate Early Gene Induction in Pituitary Gonadotropes
Autor:
Emily A. Witham, Alexander S. Kauffman, Pamela L. Mellon, Hanne M. Hoffmann, Djurdjica Coss, Jason D. Meadows, Shadi Shojaei
Publikováno v:
Molecular Endocrinology. 27:1283-1294
Kisspeptin signaling through its receptor, Kiss1R, is crucial for many reproductive functions including puberty, sex steroid feedback, and overall fertility. Although the importance of Kiss1R in the brain is firmly established, its role in regulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa1bb53e3332dd9dcf2d4635b7dfa65b
https://doi.org/10.1210/me.2012-1405
https://doi.org/10.1210/me.2012-1405
Publikováno v:
Endocrinology. 153:4522-4532
Sex steroid hormone production and feedback mechanisms are critical components of the hypothalamic-pituitary-gonadal (HPG) axis and regulate fetal development, puberty, fertility, and menopause. In female mammals, developmental exposure to excess and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741b91eb68684d07b0667809c8b41ab3
https://doi.org/10.1210/en.2012-1283
https://doi.org/10.1210/en.2012-1283
Multiple homeodomain transcription factors are crucial for pituitary organogenesis and cellular differentiation. A homeodomain repressor, Msx1, is expressed from the ventral aspect of the developing anterior pituitary and implicated in gonadotrope di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4444811028e4846b0dc8e8e6447bdc0
https://europepmc.org/articles/PMC3589667/
https://europepmc.org/articles/PMC3589667/
Autor:
Harvey A. Lardin, Samuel C. Dudley, Ali A. Sovari, Elena Dolmatova, Shahriar Iravanian, Heather S. Duffy, Brett S. Harris, Hong D. Xiao, Robert G. Gourdie, Emily A. Witham, Zhe Jiao, Hong Liu, Kenneth E. Bernstein
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 89(7)
Renin-angiotensin system (RAS) activation is associated with arrhythmias. We investigated the effects of RAS inhibition in cardiac-specific angiotensin-converting enzyme (ACE) overexpression (ACE 8/8) mice, which exhibit proclivity to ventricular tac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689cad1531f466c4a2f1b937fb3a9b6c
https://pubmed.ncbi.nlm.nih.gov/21553032
https://pubmed.ncbi.nlm.nih.gov/21553032
Autor:
Carlos J. Gallego, Kenneth E. Bernstein, Shahriar Iravanian, Samuel C. Dudley, Vijaykumar S. Kasi, Emily A. Witham, Lijuan L. Shang, Zhe Jiao, Jonathan J. Langberg, Hong D. Xiao
Renin-angiotensin (RAS) system activation is associated with an increased risk of sudden death. Previously, we used cardiac-restricted angiotensin-converting enzyme (ACE) overexpression to construct a mouse model of RAS activation. These ACE 8/8 mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb102054fd5208ae6c1488d7a2fcfa7e
https://europepmc.org/articles/PMC3160110/
https://europepmc.org/articles/PMC3160110/