Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Emily, Dakoulas"'
Publikováno v:
Toxicology Mechanisms and Methods. 27:518-527
DON (6-diazo-5-oxo-l-norleucine), a glutamine antagonist, was demonstrated to exhibit analgesic, antibacterial, antiviral and anticancer properties. The study was performed to characterize its in vitro and in vivo genetic toxicity potential. DON was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825b7a3d426c6b32704aacd2a9db24a9
https://doi.org/10.1080/15376516.2017.1333552
https://doi.org/10.1080/15376516.2017.1333552
Autor:
Kamala Pant, Emily Dakoulas, Valentine O. Wagner, Rohan Kulkarni, Shannon W. Bruce, Edgar Andrus, Nicola J. Hewitt, Sandra Springer, Michelle Klug Laforce, Jamie E. Sly, Mark Cecil
Publikováno v:
Environmental and Molecular Mutagenesis. 57:483-496
Bacterial mutation assays are conducted routinely as part of the safety assessment of new chemicals. The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay, required for regulatory submissions. Higher throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72d77ce161f569c8c27677e8661d01f5
https://doi.org/10.1002/em.22014
https://doi.org/10.1002/em.22014
Autor:
John Nicolette, Alison Kondratiuk, G. Jayakumar, Paul Sonders, Meredith Crosby, A. Patel, Emily Dakoulas, Joel Murray, Kamala Pant, R. Vicente, K. Datta, M. Mathur, Rohan Kulkarni, Kyle L. Kolaja
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 100
The bacterial reverse mutation assay (Ames) is a fundamental genetic toxicology test, and efforts to miniaturize the regulatory GLP version are essential in assessing genotoxic liabilities earlier in the drug development pipeline. Two versions of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623336ead26e589cf83fdf5be3a0b00a
https://pubmed.ncbi.nlm.nih.gov/30401633
https://pubmed.ncbi.nlm.nih.gov/30401633
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis.
Benzonatate (TESSALON®) is a peripherally acting oral antitussive. It undergoes rapid ester hydrolysis producing 4-(butylamino) benzoic acid (BBA) and methylated polyethylene glycol (MPG) metabolites, which are eliminated in urine and feces. The non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9871dab8b2464e63a94cf5f2bfabcc94
https://pubmed.ncbi.nlm.nih.gov/29704989
https://pubmed.ncbi.nlm.nih.gov/29704989
Autor:
Kamala, Pant, Shannon, Bruce, Jamie, Sly, Michelle, Klug Laforce, Sandra, Springer, Mark, Cecil, Edgar, Andrus, Emily, Dakoulas, Valentine O, Wagner, Nicola J, Hewitt, Rohan, Kulkarni
Publikováno v:
Environmental and molecular mutagenesis. 57(6)
Bacterial mutation assays are conducted routinely as part of the safety assessment of new chemicals. The OECD Test Guideline (TG) 471 describes the conduct of the standard agar plate Ames assay, required for regulatory submissions. Higher throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01231ac97590d164f541624e28262de7
https://pubmed.ncbi.nlm.nih.gov/27198925
https://pubmed.ncbi.nlm.nih.gov/27198925