Výsledky vyhledávání - "Emilio Merlo‐Pich"

Akademický článek

Digital biomarker‐based individualized prognosis for people at risk of dementia

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)

Abstract Background Research investigating treatments and interventions for cognitive decline fail due to difficulties in accurately recognizing behavioral signatures in the presymptomatic stages of the disease. For this validation study, we took our

Externí odkaz: https://doaj.org/article/107b6ab452dc4d0385a58c63daf4cf50

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Akademický článek

Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections.

Autor: Enrico Domenici, David R Willé, Federica Tozzi, Inga Prokopenko, Sam Miller, Astrid McKeown, Claire Brittain, Dan Rujescu, Ina Giegling, Christoph W Turck, Florian Holsboer, Edward T Bullmore, Lefkos Middleton, Emilio Merlo-Pich, Robert C Alexander, Pierandrea Muglia

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9166 (2010)

Despite significant research efforts aimed at understanding the neurobiological underpinnings of psychiatric disorders, the diagnosis and the evaluation of treatment of these disorders are still based solely on relatively subjective assessment of sym

Externí odkaz: https://doaj.org/article/dffa57229cd345d5bc9d1e4a410f66f9

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Akademický článek

Velusetrag rescues GI dysfunction, gut inflammation and dysbiosis in a mouse model of Parkinson’s disease

Autor: Jessica Grigoletto, Fabiana Miraglia, Laura Benvenuti, Carolina Pellegrini, Sara Soldi, Serena Galletti, Antonino Cattaneo, Emilio Merlo Pich, Maria Grimaldi, Emanuela Colla, Loredana Vesci

Publikováno v: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)

Abstract In patients with Parkinson’s disease (PD), constipation is common, and it appears in a prodromal stage before the hallmark motor symptoms. The present study aimed to investigate whether Velusetrag, a selective 5‑HT4 receptor agonist, may

Externí odkaz: https://doaj.org/article/e033f9b868f44b3b9f1b3b747ced7510

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Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery

Publikováno v: Molecular Therapy. 31:362-373

The uneven worldwide vaccination coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emergence of variants escaping immunity call for broadly effective and easily deployable therapeutic agents. We have previously describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e89cbc46bc1b4fe0245292e9f42b43
https://doi.org/10.1016/j.ymthe.2022.09.010

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The 5-HT4 receptor agonist, Velusetrag, rescues GI dysfunction, gut inflammation and dysbiosis in the A53T αS mouse model of Parkinson’s Disease

Autor: Emanuela Colla, Jessica Grigoletto, Fabiana Miraglia, Laura Benvenuti, Carolina Pellegrini, Sara Soldi, Serena Galletti, Antonino Cattaneo, Emilio Merlo Pich, Maria Grimaldi, Loredana Vesci

In patients with Parkinson’s disease (PD), constipation is common, and it appears in a prodromal stage before the hallmark motor symptoms. The present study aimed to investigate whether Velusetrag, a selective 5‑HT4 receptor agonist, may be a sui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::010e926f9400ce35ef56501233f85f93
https://doi.org/10.21203/rs.3.rs-2625763/v1

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Social withdrawal and neurocognitive correlates in schizophrenia

Autor: Domenico De Donatis, Martien J H Kas, Stefano Porcelli, Amy C. Bilderbeck, Emilio Merlo Pich, Diana De Ronchi, Alessandro Serretti

Publikováno v: INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 37(3), 102-109. LIPPINCOTT WILLIAMS & WILKINS

Background: Social withdrawal constitutes a clinical manifestation of social dysfunction in SCZ that has a high impact on the quality of life of patients. Poor neurocognitive performance has been associated with poor functional outcome in SCZ in past

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f79c9a18b26a19a83e3aeba6bd56a2
https://hdl.handle.net/11585/898953

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Safety, tolerability, pharmacokinetics, pharmacodynamics, bioavailability and food effect of single doses of soticlestat in healthy subjects

Autor: Emilio Merlo Pich, Grace Chen, Michael Cwik, John Affinito, Hélène M. Faessel, Shining Wang

Publikováno v: British Journal of Clinical Pharmacology

Aims Soticlestat is a first-in-class selective inhibitor of cholesterol 24-hydroxylase, the enzyme that converts brain cholesterol to 24S-hydroxycholesterol (24HC), a positive allosteric modulator of N-methyl-D-aspartate receptors. Soticlestat is und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a0db4de110188f9846d73125cfb3b9
https://doi.org/10.1111/bcp.14854

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Longitudinal study based on a safety registry for malaria patients treated with artenimol–piperaquine in six European countries

Publikováno v: Malaria Journal, Vol 20, Iss 1, Pp 1-14 (2021)
Malaria journal, 20 (1
Malaria Journal
Malaria Journal, BioMed Central, 2021, 20 (1), pp.214. ⟨10.1186/s12936-021-03750-x⟩
MALARIA JOURNAL
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
Malaria Journal, 20(1). BMC

Background: European travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac issues, of artenimol (previously dihydroart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7551079ea4835285fd67c2955663a84a
https://doaj.org/article/920a0808da52452c957698e9a4d64b34

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Involvement of DA D3 Receptors in Structural Neuroplasticity of Selected Limbic Brain Circuits: Possible Role in Treatment-Resistant Depression

Autor: Emilio, Merlo Pich, Laura, Cavalleri, Caterina, Toma, Ginetta, Collo

Publikováno v: Current topics in behavioral neurosciences. 60

Structural neuroplasticity in the adult brain is a process involving quantitative changes of the number and size of neurons and of their dendritic arborization, axon branching, spines, and synapses. These changes can occur in specific neural circuits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a257c4655d9f957768f2b6a3cac25686
https://pubmed.ncbi.nlm.nih.gov/35538302

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