Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Emilio Mateev"'
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-6 (2024)
Cytochrome P450 is a heme-containing superfamily accountable for the oxidation of various pharmacologically active drugs. The aim of this study was to conduct in silico and in vitro activity assessments of recently synthesized pyrrole-based compounds
Externí odkaz:
https://doaj.org/article/266566de168846f69b24662b0383e027
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-10 (2024)
The detection of pyrrole rings in numerous organic compounds with various pharmacological activities, emphasizes its huge importance in medicinal chemistry. Thus, the synthesis of pyrroles continues to arouse interest and Paal-Knorr condensation is c
Externí odkaz:
https://doaj.org/article/1d79dcf1c5ee4607a7014d9d75a9a6c3
Autor:
Emilio Mateev, Ali Irfan, Alexandrina Mateeva, Magdalena Kondeva-Burdina, Maya Georgieva, Alexander Zlatkov
Publikováno v:
Pharmacia, Vol 71, Iss , Pp 1-7 (2024)
Virtual screening is emerging as a highly applied technique and gained prominence as widely used method for the search and identification of potential hits, significantly reducing the time needed to discover novel and effective compounds compared to
Externí odkaz:
https://doaj.org/article/284f397e290449b8b63f3a3f2d7f8a7c
Autor:
Emilio Mateev, Maya Georgieva
Publikováno v:
Pharmacia, Vol 70, Iss 4, Pp 1019-1026 (2023)
Considering the complex pathophysiology of Alzheimer’s disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target strategy. Thus, six pyr
Externí odkaz:
https://doaj.org/article/8875603e5b3a44e390aa9cb96c12427a
Autor:
Emilio Mateev, Magdalena Kondeva-Burdina, Maya Georgieva, Alexandrina Mateeva, Iva Valkova, Virginia Tzankova, Alexander Zlatkov
Publikováno v:
Scientia Pharmaceutica, Vol 92, Iss 2, p 18 (2024)
Considering the complex pathogenesis of Alzheimer’s disease (AD), the multitarget ligand strategy is expected to provide superior effects for the treatment of the neurological disease compared to the classic single target approach. Thus, a series o
Externí odkaz:
https://doaj.org/article/d09fa31abe3f400596318366e54b4d5f
Autor:
Alexandrina Mateeva, Magdalena Kondeva-Burdina, Emilio Mateev, Paraskev Nedialkov, Karolina Lyubomirova, Lily Peikova, Maya Georgieva, Alexander Zlatkov
Publikováno v:
Molecules, Vol 29, Iss 7, p 1474 (2024)
In the current study, chromatographic and in silico techniques were applied to investigate the biotransformation of ethyl 5-(4-bromophenyl)-1-(2-(2-(2-hydroxybenzylidene) hydrazinyl)-2-oxoethyl)-2-methyl-1H-pyrrole-3-carboxylate (11b) in hepatocytic
Externí odkaz:
https://doaj.org/article/fc3133a8f95c4afba2e7664c4aff8e2d
Autor:
Emilio Mateev, Antoaneta Balkanska-Mitkova, Lily Peikova, Maria Dimitrova, Magdalena Kondeva-Burdina
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 36, Iss 1, Pp 925-932 (2022)
AbstractCholine is an essential nutrient involved in the synthesis of acetylcholine in the cholinergic neurons. The pharmacokinetic properties of choline are well described; however, there is a lack of data about its activity toward the CYP450 superf
Externí odkaz:
https://doaj.org/article/c9bc660483e1421686dcd65d81d97930
Autor:
Borislav Angelov, Emilio Mateev, Maya Georgieva, Virginia Tzankova, Magdalena Kondeva-Burdina
Publikováno v:
Pharmacia, Vol 69, Iss 4, Pp 1013-1017 (2022)
Four pyrrole based hydazide-hydrazones with established low hepatotoxicity and promising antiproliferative activity were evaluated (at 1µM concentration) for possible inhibitory activity on human isoforms of Cytochrome P450 CYP1A2, CYP3A4 and CYP2D6
Externí odkaz:
https://doaj.org/article/c66e130240f34ba1b8648d4c18ee54c3
Autor:
Diana Tzankova, Hristina Kuteva, Emilio Mateev, Denitsa Stefanova, Alime Dzhemadan, Yordan Yordanov, Alexandrina Mateeva, Virginia Tzankova, Magdalena Kondeva-Burdina, Alexander Zlatkov, Maya Georgieva
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1198 (2023)
A series of ten new hydrazide–hydrazone derivatives bearing a pyrrole ring were synthesized and structurally elucidated through appropriate spectral characteristics. The target hydrazones were assessed for radical scavenging activity through 1,1-di
Externí odkaz:
https://doaj.org/article/ea4674433cea4832b4457cacc302e0ac
Publikováno v:
Macedonian Journal of Chemistry and Chemical Engineering, Vol 41, Iss 2 (2022)
In this study, one novel N-pyrrolyl carboxylic acid (3), the corresponding N-pyrrolyl hydrazide (5), and four new hydrazide-hydrazones (5a-d) bearing electron donating moieties were designed, synthesized, and fully elucidated by 1H NMR, FT-IR, and HR
Externí odkaz:
https://doaj.org/article/9c6e67b912614b6295f21511c87d9b2d