Výsledky vyhledávání - "Emilio Garro-Martínez"

Akademický článek

Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2

Autor: Viktor Burström, Richard Ågren, Nibal Betari, Marta Valle-León, Emilio Garro-Martínez, Francisco Ciruela, Kristoffer Sahlholm

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

The dopamine D4 receptor (D4R) is expressed in the retina, prefrontal cortex, and autonomic nervous system and has been implicated in attention deficit hyperactivity disorder (ADHD), substance use disorders, and erectile dysfunction. D4R has also bee

Externí odkaz: https://doaj.org/article/e4ac71b4fef348f685b291cd35bd0afc

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Akademický článek

mTOR Knockdown in the Infralimbic Cortex Evokes A Depressive-like State in Mouse

Autor: Emilio Garro-Martínez, Maria Neus Fullana, Eva Florensa-Zanuy, Julia Senserrich, Verónica Paz, Esther Ruiz-Bronchal, Albert Adell, Elena Castro, Álvaro Díaz, Ángel Pazos, Analía Bortolozzi, Fuencisla Pilar-Cuéllar

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 16, p 8671 (2021)

Fast and sustained antidepressant effects of ketamine identified the mammalian target of rapamycin (mTOR) signaling pathway as the main modulator of its antidepressive effects. Thus, mTOR signaling has become integral for the preclinical evaluation o

Externí odkaz: https://doaj.org/article/f8369d7517564600b7f17f1a8d4f35fd

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Structural connectivity and subcellular changes after antidepressant doses of ketamine and Ro 25-6981 in the rat: an MRI and immuno-labeling study

Autor: Arantxa Blasco-Serra, Emma Muñoz-Moreno, Fuencisla Pilar-Cuéllar, Albert Adell, Raquel Pascual-Antón, Guadalupe Soria, Emilio Garro-Martínez, Víctor M Campa, Eva Florensa-Zanuy, Xavier López-Gil

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Brain Struct Funct . 2021 Nov;226(8):2603-2616
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Brain Structure & Function

© The Author(s) 2021.
Ketamine has rapid and robust antidepressant effects. However, unwanted psychotomimetic effects limit its widespread use. Hence, several studies examined whether GluN2B-subunit selective NMDA antagonists would exhibit a be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ed966472ea1376252ac603adfb6046
https://doi.org/10.1007/s00429-021-02354-0

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Brain matrix metalloproteinase-9 activity is altered in the corticosterone mouse model of depression

Autor: Silvia Breviario, Júlia Senserrich, Eva Florensa-Zanuy, Emilio Garro-Martínez, Álvaro Díaz, Elena Castro, Ángel Pazos, Fuencisla Pilar-Cuéllar

Publikováno v: Progress in neuro-psychopharmacology and biological psychiatry 120 (2023) 110624

Major depressive disorder is a highly prevalent psychiatric condition. Metalloproteinase 9 (MMP-9), a gelatinase involved in synaptic plasticity, learning and memory processes, is elevated in both chronic stress animal models and human peripheral blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32737bbb8a4222dd2d1a12baa9db0168
https://doi.org/10.1016/j.pnpbp.2022.110624

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β-Catenin Role in the Vulnerability/Resilience to Stress-Related Disorders Is Associated to Changes in the Serotonergic System

Autor: Fuencisla Pilar-Cuéllar, Emilio Garro-Martínez, Rebeca Vidal, Josep Amigó, Albert Adell, Elena Castro, Laura Gómez-Acero, Raquel Gutiérrez-Lanza, Álvaro Díaz, Angel Pazos, Eva Florensa-Zanuy, Makoto Mark Taketo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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We previously reported that the inactivation (cKO) or the stabilization (cST) of β-catenin in cells expressing the astrocyte-specific glutamate aspartate transporter (GLAST) is associated with the vulnerability or resilience to exhibit anxious/depre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccf49ed50c347fe94eb7630841674bc
https://doi.org/10.1007/s12035-019-01841-0

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Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways

Autor: David Martín-Hernández, Angel Pazos, Elena Castro, Álvaro Díaz, Eva Florensa-Zanuy, Fuencisla Pilar-Cuéllar, Emilio Garro-Martínez, Karina S. Mac-Dowell, Albert Adell

Publikováno v: Biochem Pharmacol . 2021 Mar;185:114433
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)

Major Depression is a severe psychiatric condition with a still poorly understood etiology. In the last years, evidence supporting the neuroinflammatory hypothesis of depression has increased. In the current clinical scenario, in which the available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daef5ccd428d5212a40d1a164afd3714
http://hdl.handle.net/10902/24495

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AMPA Receptor Potentiators as Potential Rapid-Acting Antidepressants

Autor: Emilio Garro-Martínez, Albert Adell

Publikováno v: Contemporary Clinical Neuroscience ISBN: 9783030797898
Digital.CSIC. Repositorio Institucional del CSIC
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Major depressive disorder (MDD) is the leading cause of disability worldwide and contributes importantly to the global burden of morbidity according to reports from the World Health Organization. Several types of antidepressant medications are used t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4013b68f78d9ed0f7d408f7e33135aa
https://doi.org/10.1007/978-3-030-79790-4_6

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mTOR knockdown in the infralimbic cortex evokes a depressive-like state in mouse

Autor: Elena Castro, Álvaro Díaz, Verónica Paz, Julia Senserrich, Eva Florensa-Zanuy, Albert Adell, Analía Bortolozzi, Esther Ruiz-Bronchal, Angel Pazos, Emilio Garro-Martínez, Maria Neus Fullana, Fuencisla Pilar-Cuéllar

Publikováno v: Int J Mol Sci . 2021 Aug 12;22(16):8671
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
International Journal of Molecular Sciences, Vol 22, Iss 8671, p 8671 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b32cebed3685bffb974d9a74abf8fd3
http://hdl.handle.net/10902/24427

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5-HT4 Receptors Are Not Involved in the Effects of Fluoxetine in the Corticosterone Model of Depression

Autor: Valérie Compan, Elena Castro, Fuencisla Pilar-Cuéllar, Álvaro Díaz, Emilio Garro-Martínez, Angel Pazos, Josep Amigó, Rebeca Vidal Casado

Publikováno v: ACS Chem Neurosci . 2021 Jun 2;12(11):2036-2044
Digital.CSIC. Repositorio Institucional del CSIC
instname
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

Clinical and preclinical studies report the implication of 5-hydroxytryptamine 4 receptors (5-HT4Rs) in depression and anxiety. Here, we tested whether the absence of 5-HT4Rs influences the response to the antidepressant fluoxetine in mice subjected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488bf959c9aa6daebb9013309b4df17b
http://hdl.handle.net/10902/24496

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Radioligand Binding Detection of Receptors in Brain Membranes

Autor: Fuencisla Pilar-Cuellar, Elena Castro, EMILIO GARRO-MARTÍNEZ, Alvaro Diaz

Publikováno v: Neuromethods ISBN: 9781071615218
Digital.CSIC. Repositorio Institucional del CSIC
instname

Transmitters, hormones, and most of the therapeutic drugs exert their biological functions by generating signals in target cells through interaction with a receptor molecule in the cellular membrane, cytosol, or even at the nucleus of the cell. Becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304d262c018ef208c4dba4e1616485e2
https://doi.org/10.1007/978-1-0716-1522-5_6

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