Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Emilio, Casanova"'
Autor:
Sophie Edtmayer, Agnieszka Witalisz-Siepracka, Bernhard Zdársky, Kerstin Heindl, Stefanie Weiss, Thomas Eder, Sayantanee Dutta, Uwe Graichen, Sascha Klee, Omar Sharif, Rotraud Wieser, Balázs Győrffy, Valeria Poli, Emilio Casanova, Heinz Sill, Florian Grebien, Dagmar Stoiber
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-12 (2024)
Abstract Signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in patients with acute myeloid leukemia (AML). STAT3 exists in two distinct alternatively spliced isoforms, the full-length isoform STAT3α and the C-term
Externí odkaz:
https://doaj.org/article/fa3588b01db84ae4a00ac9b61c021e7a
Autor:
Agnieszka Witalisz-Siepracka, Clio-Melina Denk, Bernhard Zdársky, Lorenz Hofmann, Sophie Edtmayer, Theresa Harm, Stefanie Weiss, Kerstin Heindl, Manuel Hessenberger, Sabrina Summer, Sayantanee Dutta, Emilio Casanova, Gerald J. Obermair, Balázs Győrffy, Eva Maria Putz, Heinz Sill, Dagmar Stoiber
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Acute myeloid leukemia (AML) is a heterogenous disease characterized by the clonal expansion of myeloid progenitor cells. Despite recent advancements in the treatment of AML, relapse still remains a significant challenge, necessitating the developmen
Externí odkaz:
https://doaj.org/article/cf2694443fe34e35bace14518f251243
Autor:
Katalin Zboray, Adam V. Toth, Tímea D. Miskolczi, Krisztina Pesti, Emilio Casanova, Emanuel Kreidl, Arpad Mike, Áron Szenes, László Sági, Peter Lukacs
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Agriculturally important crop plants emit a multitude of volatile organic compounds (VOCs), which are excellent indicators of their health status and their interactions with pathogens and pests. In this study, we have developed a novel cellu
Externí odkaz:
https://doaj.org/article/bde1dc84b033479086f28e42e35f79aa
Autor:
Mohammad Sadegh Taghizadeh, Bernhard Retzl, Edin Muratspahić, Christoph Trenk, Emilio Casanova, Ali Moghadam, Alireza Afsharifar, Ali Niazi, Christian W. Gruber
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The cholecystokinin-2 receptor (CCK2R) is a G protein-coupled receptor (GPCR) that is expressed in peripheral tissues and the central nervous system and constitutes a promising target for drug development in several diseases, such as gastroi
Externí odkaz:
https://doaj.org/article/f3aa175639b547bd888cae3111ba4c3b
Autor:
Stefan Moritsch, Bernadette Mödl, Irene Scharf, Lukas Janker, Daniela Zwolanek, Gerald Timelthaler, Emilio Casanova, Maria Sibilia, Thomas Mohr, Lukas Kenner, Dietmar Herndler-Brandstetter, Christopher Gerner, Mathias Müller, Birgit Strobl, Robert Eferl
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Janus kinase Tyk2 is implicated in cancer immune surveillance, but its role in solid tumors is not well defined. We used Tyk2 knockout mice (Tyk2Δ/Δ) and mice with conditional deletion of Tyk2 in hematopoietic (Tyk2ΔHem) or intestinal epithelial c
Externí odkaz:
https://doaj.org/article/ec4f1b9c22f84cf89d8018da851833f7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15440 (2022)
The field of targeted protein degradation (TPD) is a rapidly developing therapeutic modality with the promise to tame disease-relevant proteins in ways that are difficult or impossible to tackle with other strategies. While we move into the third dec
Externí odkaz:
https://doaj.org/article/c4bc3e09b13b4cecbf6027a46217a2bd
Autor:
Petra Aigner, Tatsuaki Mizutani, Jaqueline Horvath, Thomas Eder, Stefan Heber, Karin Lind, Valentin Just, Herwig P. Moll, Assa Yeroslaviz, Michael J.M. Fischer, Lukas Kenner, Balázs Győrffy, Heinz Sill, Florian Grebien, Richard Moriggl, Emilio Casanova, Dagmar Stoiber
Publikováno v:
Blood Advances, Vol 3, Iss 13, Pp 1989-2002 (2019)
Abstract: Signal transducer and activator of transcription 3 (STAT3) exists in 2 alternatively spliced isoforms, STAT3α and STAT3β. Although truncated STAT3β was originally postulated to act as a dominant-negative form of STAT3α, it has been show
Externí odkaz:
https://doaj.org/article/e3234ff4c4b749ff8efe1c153e7ffe4b
Autor:
Peter Lukacs, Mátyás C. Földi, Luca Valánszki, Emilio Casanova, Beáta Biri-Kovács, László Nyitray, András Málnási-Csizmadia, Arpad Mike
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Sodium channel inhibitor drugs decrease pathological hyperactivity in various diseases including pain syndromes, myotonia, arrhythmias, nerve injuries and epilepsies. Inhibiting pathological but not physiological activity, however, is a majo
Externí odkaz:
https://doaj.org/article/f48d2435c9aa4403b15cfc5aca00707f
Autor:
Ilija Crnčec, Madhura Modak, Claire Gordziel, Jasmin Svinka, Irene Scharf, Stefan Moritsch, Paulina Pathria, Michaela Schlederer, Lukas Kenner, Gerald Timelthaler, Mathias Müller, Birgit Strobl, Emilio Casanova, Editha Bayer, Thomas Mohr, Johannes Stöckl, Karlheinz Friedrich, Robert Eferl
Publikováno v:
Molecular Oncology, Vol 12, Iss 4, Pp 514-528 (2018)
The interferon‐inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex‐specific STAT1 functions in colitis and colitis‐associated colorectal cancer (CRC) using mice with specific STAT1 deletion in
Externí odkaz:
https://doaj.org/article/470ce83f7ffc4801a6ede8c87a159f05
Autor:
Jacqueline Wallwitz, Petra Aigner, Elisabeth Gadermaier, Eva Bauer, Emilio Casanova, Anton Bauer, Dagmar Stoiber
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220935 (2019)
Endostatin, the C-terminal fragment of type XVIII collagen, was shown to be one of the most potent endothelial cell-specific inhibitors of angiogenesis. As altered circulating endostatin concentration is associated with impaired kidney function, new
Externí odkaz:
https://doaj.org/article/34591c37875f40aca21503cc7f8efd1a