Výsledky vyhledávání - "Emilija Makaji"

Effects in Rats of Maternal Exposure to Raspberry Leaf and Its Constituents on the Activity of Cytochrome P450 Enzymes in the Offspring

Autor: Denis J. Crankshaw, Alison C. Holloway, Emilija Makaji, Shirley Ho

Publikováno v: International Journal of Toxicology. 30:216-224

The goal of our study was to determine whether maternal exposure to red raspberry leaf (RRL) and its constituents can permanently alter biotransformation of fluorogenic substrates by cytochrome P450 (CYP) in the livers of male and female offspring. N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b60780d96d3b2670553bf5337b26e6f
https://doi.org/10.1177/1091581810388307

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Effects of Cytochrome P450 Inhibitors on the Biotransformation of Fluorogenic Substrates by Adult Male Rat Liver Microsomes and cDNA-Expressed Rat Cytochrome P450 Isoforms

Autor: Pamela Shen, Cristina S. Trambitas, Emilija Makaji, Alison C. Holloway, Denis J. Crankshaw

Publikováno v: Toxicological Sciences. 113:293-304

We have evaluated the use of a panel of six fluorogenic cytochrome P450 (CYP) substrates as a potential tool for rapid screening for global changes in CYP activity in rats under different physiological conditions. The biotransformation of 3-[2-(N,N-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26be4defefc55028829ccbe7fdd2946d
https://doi.org/10.1093/toxsci/kfp255

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Effect of Maternal Raspberry Leaf Consumption in Rats on Pregnancy Outcome and the Fertility of the Female Offspring

Autor: Alison C. Holloway, Shirley Ho, Jill R. Johnson, Denis J. Crankshaw, Boya Xiong, Emilija Makaji

Publikováno v: Reproductive Sciences. 16:605-609

The use of herbal medicines by pregnant women is on the rise. However, there is limited information regarding the safety of these compounds during pregnancy. Therefore, the goal of this study was to explore the consequences of raspberry leaf use duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc1f45d0616adbbb022d39086081f95
https://doi.org/10.1177/1933719109332823

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Human Cytochrome P450 Liability Studies of trans-Dihydronarciclasine: A Readily Available, Potent, and Selective Cancer Cell Growth Inhibitor

Autor: Nesrin Vurgun, Jerald J. Nair, Denis J Crankshaw, Emilija Makaji, Alison C Holloway, Amol Thorat, Siyaram Pandey, James McNulty

Publikováno v: Journal of Natural Products. 74:106-108

The cytochrome P45O activities of the naturally occurring Amaryllidaceae alkaloid narciclasine (3), isolated from Narcissus pseudonarcissus, and synthetic derivative trans-dihydronarciclasine (5) are reported. While narciclasine was found to possess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7733f6a1a2b4b5031ce8ad63139fc461
https://doi.org/10.1021/np100657w

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Effect of environmental contaminants on Beta cell function

Autor: Emilija Makaji, Sandeep Raha, Michael G. Wade, Alison C. Holloway

Publikováno v: International journal of toxicology. 30(4)

There is an increasing concern that chemicals in the environment are contributing to the global rise in the prevalence of type 2 diabetes (T2D). However, there is limited evidence for direct effects of these chemicals on beta cell function. Therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366bb303f97f0b72e5db1d4bdced048a
https://pubmed.ncbi.nlm.nih.gov/21705745

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