Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Emilie Picard"'
Autor:
Anaïs Françon, Kimberley Delaunay, Thara Jaworski, Cécile Lebon, Emilie Picard, Jenny Youale, Francine Behar-Cohen, Alicia Torriglia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Light is known to induce retinal damage affecting photoreceptors and retinal pigment epithelium. For polychromatic light, the blue part of the spectrum is thought to be the only responsible for photochemical damage, leading to the establishm
Externí odkaz:
https://doaj.org/article/0263a4d97ec9441d85a812984e60d076
Autor:
Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney, Chris P. Verschoor
Publikováno v:
Immunity & Ageing, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting that this so-called “i
Externí odkaz:
https://doaj.org/article/7ebbef19822844c38fada3f9ca189613
Autor:
Chris P. Verschoor, Emilie Picard, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel
Publikováno v:
Frontiers in Aging, Vol 3 (2023)
Granzymes are a family of serine-proteases that act as critical mediators in the cytolytic and immunomodulatory activities of immune cells such as CD8+ T-cells and natural killer (NK) cells. Previous work indicates that both granzyme B (GZB) and K (G
Externí odkaz:
https://doaj.org/article/01483b3e1f824e2f8aff87686c52a556
Autor:
Jordan D. Lewicky, Alexandrine L. Martel, Nya L. Fraleigh, Emilie Picard, Leila Mousavifar, Arnaldo Nakamura, Francisco Diaz-Mitoma, René Roy, Hoang-Thanh Le
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2710 (2022)
Perhaps the greatest limitation for the continually advancing developments in cancer immunotherapy remains the immunosuppressive tumor microenvironment (TME). The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) axis is an emergi
Externí odkaz:
https://doaj.org/article/0e88224ddd4740389e6737b8d7385f2e
Autor:
Jenny Youale, Karine Bigot, Bindu Kodati, Thara Jaworski, Yan Fan, Nana Yaa Nsiah, Nathaniel Pappenhagen, Denise M. Inman, Francine Behar-Cohen, Thierry Bordet, Emilie Picard
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12753 (2022)
Iron is essential for retinal metabolism, but an excess of ferrous iron causes oxidative stress. In glaucomatous eyes, retinal ganglion cell (RGC) death has been associated with dysregulation of iron homeostasis. Transferrin (TF) is an endogenous iro
Externí odkaz:
https://doaj.org/article/4ae0ccd40af9402ea9d307eb205ce714
Autor:
Graham Pawelec, Emilie Picard
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/4723df66469c45dbac7c927d8716b978
Autor:
Graham Pawelec, Emilie Picard, Alexandrine Martel, Alain Simard, Hoang-Thanh Le, Chris Verschoor, Grace Ma
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/abc722f492904dde8ea6f556a49e36f4
Autor:
Alejandra Daruich, Emilie Picard, Justine Guégan, Thara Jaworski, Léa Parenti, Kimberley Delaunay, Marie-Christine Naud, Marianne Berdugo, Jeffrey H. Boatright, Francine Behar-Cohen
Publikováno v:
Pharmaceuticals, Vol 15, Iss 3, p 334 (2022)
Ursodeoxycholic (UDCA) and tauroursodeoxycholic (TUDCA) acids have shown neuroprotective properties in neurodegenerative diseases, but differential effects of the two bile acids have been poorly explored. The aim of this study was to evaluate the neu
Externí odkaz:
https://doaj.org/article/2e2b6c2e808c42389098aa2171201077
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit microsatellite instability (MSI), a molecular indicator of defective DN
Externí odkaz:
https://doaj.org/article/ed70cda29f53420d8b9dcf7e4d2ab0b3
Autor:
Marianne Berdugo, Kimberley Delaunay, Cécile Lebon, Marie-Christine Naud, Lolita Radet, Léa Zennaro, Emilie Picard, Alejandra Daruich, Jacques Beltrand, Elsa Kermorvant-Duchemin, Michel Polak, Patricia Crisanti, Francine F. Behar-Cohen
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1095 (2021)
Diabetic retinopathy (DR) remains a major cause of vision loss, due to macular edema, retinal ischemia and death of retinal neurons. We previously demonstrated that acute administration of glibenclamide into the vitreous, or given orally at a non-hyp
Externí odkaz:
https://doaj.org/article/7cc19c0cbf3b4d40bda0285fa3074a27