Structure Elucidation, Total Synthesis, Antibacterial In Vivo Efficacy and Biosynthesis Proposal of Myxobacterial Corramycin

Autor: Cédric Couturier, Sebastian Groß, Alexander von Tesmar, Judith Hoffmann, Selina Deckarm, Anouchka Fievet, Nelly Dubarry, Thomas Taillier, Christoph Pöverlein, Heike Stump, Michael Kurz, Luigi Toti, Sabine Haag Richter, Dietmar Schummer, Philippe Sizun, Michael Hoffmann, Ram Prasad Awal, Nestor Zaburannyi, Kirsten Harmrolfs, Joachim Wink, Emilie Lessoud, Thierry Vermat, Veronique Cazals, Sandra Silve, Armin Bauer, Michael Mourez, Laurent Fraisse, Corinne Leroi‐Geissler, Astrid Rey, Stéphanie Versluys, Eric Bacqué, Rolf Müller, Stephane Renard

Publikováno v: Angewandte Chemie (International ed. in English). 61(51)

Herein, we describe the myxobacterial natural product Corramycin isolated from Corallococcus coralloides. The linear peptide structure contains an unprecedented (2R,3S)-γ-N-methyl-β-hydroxy-histidine moiety. Corramycin exhibits anti-Gram-negative a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf736297578c1c29ac5d3fb1e5eac92d
https://pubmed.ncbi.nlm.nih.gov/36197755

Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae

Autor: Lilia Boucinha, Emilie Lessoud, Lucile Pantel, Maxime Gualtieri, Anne Lanois, Emilie Racine, Alain Givaudan, Paulo Juarez, Marine Serri

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2021, 65 (5), ⟨10.1128/AAC.00139-21⟩

International audience; NOSO-502 is a preclinical antibiotic candidate of the odilorhabdin class. This compound exhibits activity against Enterobacteriaceae pathogens, including carbapenemase-producing bacteria and most of the colistin (CST)-resistan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c2fcc7f950c8b967776b287b368d82
https://hal.archives-ouvertes.fr/hal-03245424