SARS‐CoV‐2 sculpts the immune system to induce sustained virus‐specific naïve‐like and memory B‐cell responses

Autor: Leire de Campos‐Mata, Sonia Tejedor Vaquero, Roser Tachó‐Piñot, Janet Piñero, Emilie K Grasset, Itziar Arrieta Aldea, Natalia Rodrigo Melero, Carlo Carolis, Juan P Horcajada, Andrea Cerutti, Judit Villar‐García, Giuliana Magri

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 9, Pp n/a-n/a (2021)

Abstract Objectives SARS‐CoV‐2 infection induces virus‐reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus‐specific naïve B cells and their impact on immunit

Externí odkaz: https://doaj.org/article/28a562c0f76843f5b9ea468ad9d87eab

Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity

Autor: Mathieu Uzzan, Jerome C. Martin, Luka Mesin, Alexandra E. Livanos, Tomas Castro-Dopico, Ruiqi Huang, Francesca Petralia, Giuliana Magri, Shashi Kumar, Qing Zhao, Adam K. Rosenstein, Minami Tokuyama, Keshav Sharma, Ryan Ungaro, Roman Kosoy, Divya Jha, Jeremy Fischer, Harpriya Singh, Mary E. Keir, Nandhini Ramamoorthi, William E. O’Gorman, Benjamin L. Cohen, Adeeb Rahman, Francesca Cossarini, Akihiro Seki, Louise Leyre, Sonia Tejedor Vaquero, Sakteesh Gurunathan, Emilie K. Grasset, Bojan Losic, Marla Dubinsky, Alexander J. Greenstein, Zoe Gottlieb, Peter Legnani, James George, Haritz Irizar, Aleksandar Stojmirovic, Carrie Brodmerkel, Andrew Kasarkis, Bruce E. Sands, Glaucia Furtado, Sergio A. Lira, Zewen K. Tuong, Huaibin M. Ko, Andrea Cerutti, Charles O. Elson, Menna R. Clatworthy, Miriam Merad, Mayte Suárez-Fariñas, Carmen Argmann, Jason A. Hackney, Gabriel D. Victora, Gwendalyn J. Randolph, Ephraim Kenigsberg, Jean Frederic Colombel, Saurabh Mehandru

Publikováno v: Nat Med

B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis (UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; validation cohort 1, n = 664; and validation cohort 2, n =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174661bdc81a07d2cf2f022bc6ddd914
https://doi.org/10.1038/s41591-022-01680-y

SARS‐CoV‐2 sculpts the immune system to induce sustained virus‐specific naïve‐like and memory B‐cell responses

Autor: Giuliana Magri, Carlo Carolis, Sonia Tejedor Vaquero, Roser Tachó-Piñot, Emilie K. Grasset, Janet Piñero, Judit Villar-García, Juan Pablo Horcajada, Itziar Arrieta Aldea, Natalia Rodrigo Melero, Leire de Campos-Mata, Andrea Cerutti

Publikováno v: de Campos Mata, L, Tejedor Vaquero, S & Tachó Piñot, R 2021, ' SARS-CoV-2 sculpts the immune system to induce sustained virus-specific naïve-like and memory B-cell responses ', Clinical & translational immunology, vol. 10, no. 9, e1339 . https://doi.org/10.1002/cti2.1339
Clinical & Translational Immunology
Clinical & Translational Immunology, Vol 10, Iss 9, Pp n/a-n/a (2021)

Objectives SARS‐CoV‐2 infection induces virus‐reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus‐specific naïve B cells and their impact on immunity and imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3291835ed88f31644200a18a0d3cf7
https://doi.org/10.1002/cti2.1339

PD42-03 HIGH LEVELS OF BASELINE IGG1, IGG3, AND IFN-G MAY BE ASSOCIATED WITH RESISTANCE TO BCG THERAPY FOR TREATMENT OF NMIBC

Autor: Yuan-Shuo Wang, John P. Sfakianos, Li Wang, Peter Wiklund, Andrew Charap, Amir Horowitz, Ketan K. Badani, Giuliana Magri, Rafael Cabal, Yong Lee, Jorge Daza, Rachel Brody, Bérengère Salomé, Nina Bharwadj, Emilie K. Grasset, Kristin G. Beaumont, Jun Zhu, Robert Sebra, Reza Mehrazin, Adam M. Farkas, Dominic LaRoche, Matthew D. Galsky

Publikováno v: Journal of Urology. 206

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b75aac299506c1ece7cdb2b4def6ec78
https://doi.org/10.1097/ju.0000000000002056.03

Mutations make gut antibodies promiscuous

Autor: Andrea Cerutti, Emilie K. Grasset

Publikováno v: Journal of Experimental Medicine. 217

In this issue, Kabbert et al. (https://doi.org/10.1084/jem.20200275) show that intestinal antibodies from healthy subjects or patients with Crohn’s disease cross-target diverse but distinct communities of the gut microbiota through a mechanism invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f6e8a7b398c57818343144a3ccef24
https://doi.org/10.1084/jem.20201340