Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Emilie J. Cosway"'
Autor:
Emilie J. Cosway, Kieran D. James, Andrea J. White, Sonia M. Parnell, Andrea Bacon, Andrew N. J. McKenzie, W. E. Jenkinson, Graham Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from e
Externí odkaz:
https://doaj.org/article/2f6fc6882f6e4f17b1ea21f1939791f2
Autor:
Beth Lucas, Andrea J. White, Fabian Klein, Clara Veiga-Villauriz, Adam Handel, Andrea Bacon, Emilie J. Cosway, Kieran D. James, Sonia M. Parnell, Izumi Ohigashi, Yousuke Takahama, William E. Jenkinson, Georg A. Hollander, Wei-Yu Lu, Graham Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of the medulla for thymus function is
Externí odkaz:
https://doaj.org/article/2a0c9868ae7e45eaa4dd7a3a89e0aac1
Autor:
Beth Lucas, Andrea J. White, Emilie J. Cosway, Sonia M. Parnell, Kieran D. James, Nick D. Jones, Izumi Ohigashi, Yousuke Takahama, William E. Jenkinson, Graham Anderson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation
Externí odkaz:
https://doaj.org/article/a71a0ce69050482687895e76227ecd62
Publikováno v:
Seminars in Immunopathology
αβT cells are an essential component of effective immune responses. The heterogeneity that lies within them includes subsets that express diverse self-MHC-restricted αβT cell receptors, which can be further subdivided into CD4+ helper, CD8+ cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca74ff1e96763c230e4764fc88609d1
http://europepmc.org/articles/PMC7925449
http://europepmc.org/articles/PMC7925449
Autor:
Emilie J. Cosway, Andrea J. White, Sonia M. Parnell, Edina Schweighoffer, Helen E. Jolin, Andrea Bacon, Hans-Reimer Rodewald, Victor Tybulewicz, Andrew N. J. McKenzie, William E. Jenkinson, Graham Anderson
Publikováno v:
Science immunology. 7(69)
Therapeutic interventions used for cancer treatment provoke thymus damage and limit the recovery of protective immunity. Here, we show that eosinophils are an essential part of an intrathymic type 2 immune network that enables thymus recovery after a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8297804b6b50ac594eda43d133d9ec0
https://pubmed.ncbi.nlm.nih.gov/35275754
https://pubmed.ncbi.nlm.nih.gov/35275754
Autor:
Abdullah S. Alawam, Emilie J. Cosway, Kieran D. James, Beth Lucas, Andrea Bacon, Sonia M. Parnell, Andrea J. White, William E. Jenkinson, Graham Anderson
Publikováno v:
The Journal of Experimental Medicine
The thymus ensures immune tolerance by synchronizing thymocyte development and selection. Alawam et al. show that a functional uncoupling of these events occurs after bone marrow transplantation, which results in post-transplant tolerance loss and au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc063c0a2ede900ee3115d6ad0dbfa7
http://europepmc.org/articles/PMC8679781
http://europepmc.org/articles/PMC8679781
Autor:
Graham Anderson, Izumi Ohigashi, William E. Jenkinson, Andrea J. White, Beth Lucas, Kieran D. James, Nick D. Jones, Emilie J. Cosway, Sonia M. Parnell, Yousuke Takahama
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly understood. Here we examine medullary thymic epithelial cell (mTEC) heterogeneity and its influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912937b69d56381c25d80769a51bad22
https://doi.org/10.1038/s41467-020-16041-x
https://doi.org/10.1038/s41467-020-16041-x
Publikováno v:
Trends in immunology. 40(4)
In the thymus, distinct cortex and medulla areas emphasize the division of labor in selection events shaping the αβT cell receptor repertoire. For example, MHC restriction via positive selection is a unique property of epithelial cells in the thymi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3704f3dcf052a613fc913a5f5c4527e2
https://pubmed.ncbi.nlm.nih.gov/30803714
https://pubmed.ncbi.nlm.nih.gov/30803714
Autor:
Alexei V. Tumanov, William E. Jenkinson, Sonia M. Parnell, Emilie J. Cosway, Graham Anderson, Beth Lucas, Kieran D. James, Carl F. Ware
Publikováno v:
The Journal of Immunology Author Choice
The recruitment of lymphoid progenitors to the thymus is essential to sustain T cell production throughout life. Importantly, it also limits T lineage regeneration following bone marrow transplantation, and so contributes to the secondary immunodefic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575ef3ecf90195db7f7c2d147cc6cc5b
http://europepmc.org/articles/PMC5026032
http://europepmc.org/articles/PMC5026032
Autor:
Kieran D, James, Emilie J, Cosway, Beth, Lucas, Andrea J, White, Sonia M, Parnell, Manuela, Carvalho-Gaspar, Alexei V, Tumanov, Graham, Anderson, William E, Jenkinson
Publikováno v:
The Journal of Experimental Medicine
Thymic emigration is essential for establishing T cell immunity. We show the requirement for LTβR segregates from its control of medullary epithelium. Instead, our study demonstrates LTβR expression by the endothelium acts to rate limit thymocyte e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a665282b2140bcee5e4028ae1e672c0d
https://pubmed.ncbi.nlm.nih.gov/30425120
https://pubmed.ncbi.nlm.nih.gov/30425120