Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Emilie Hitzerd"'
Autor:
Michelle Broekhuizen, Emilie Hitzerd, Thierry P. P. van den Bosch, Jasper Dumas, Robert M. Verdijk, Bas B. van Rijn, A. H. Jan Danser, Casper H. J. van Eijck, Irwin K. M. Reiss, Dana A. M. Mustafa
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Preeclampsia is a severe placenta-related pregnancy disorder that is generally divided into two subtypes named early-onset preeclampsia (onset
Externí odkaz:
https://doaj.org/article/3aa395aaf12f46ff9ecebd5b5edee77b
Autor:
Emilie Hitzerd, Michelle Broekhuizen, Katrina M. Mirabito Colafella, Marija Glisic, René de Vries, Birgit C.P. Koch, Michiel A. de Raaf, Daphne Merkus, Sam Schoenmakers, Irwin K.M. Reiss, A.H. Jan Danser, Sinno H.P. Simons
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 447-455 (2019)
Background: The phosphodiesterase-5 inhibitor (PDE5) sildenafil has emerged as a promising treatment for preeclampsia (PE). However, a sildenafil trial was recently halted due to lack of effect and increased neonatal morbidity. Methods: Ex vivo dual-
Externí odkaz:
https://doaj.org/article/ed90b41057684b51983c4552e8271032
Autor:
Emilie Hitzerd, Igna F. Reijnders, Annemarie G. M. G. J. Mulders, Anton H. J. Koning, Irwin K. M. Reiss, A. H. Jan Danser, Régine P. M. Steegers-Theunissen, Sinno H. P. Simons, Maria P. H. Koster
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
ObjectiveTo explore the correlation between in vivo placental volumetric parameters in the first trimester of pregnancy and ex vivo parameters of fetoplacental vascular function after delivery.MethodsIn ten singleton physiological pregnancies, placen
Externí odkaz:
https://doaj.org/article/7883fe5fde004de6a2ddc6032d2e34e7
Autor:
Emilie Hitzerd, Marcel E Meima, Zhongli Chen, Selmar Leeuwenburgh, Lunbo Tan, Yolanda B. de Rijke, Edward Visser, Jan Danser, Robin Peteers, Irwin Reiss, Rutchanna M S Jongejan, Michelle Broekhuizen, Rugina I. Neuman
Publikováno v:
Thyroid : official journal of the American Thyroid Association, 33(5), 625-631. Mary Ann Liebert Inc.
Background: Fetal development is crucially dependent on thyroid hormone (TH). Maternal-to-fetal transfer of TH is a prerequisite for fetal TH availability, particularly in the first half of pregnancy. The mechanisms of transplacental transport of TH,
Autor:
Michelle Broekhuizen, Rene de Vries, Marja A. W. Smits, Willem A. Dik, Sam Schoenmakers, Birgit C. P. Koch, Daphne Merkus, Irwin K. M. Reiss, A. H. Jan Danser, Sinno H. P. Simons, Emilie Hitzerd
Publikováno v:
British Journal of Pharmacology, 179(22), 5074-5088. Wiley-Blackwell
Background and Purpose Recently pentoxifylline, a non-selective phosphodiesterase inhibitor and adenosine receptor antagonist, has attracted much interest for the treatment of the increased vascular resistance and endothelial dysfunction in pre-eclam
Autor:
Theo Klein, Irwin Reiss, Emilie Hitzerd, Sam Schoenmakers, Daphne Merkus, Peter Sedlmayr, A.H. Jan Danser, Yolanda B. de Rijke, Michelle Broekhuizen
Publikováno v:
Hypertension, 76(1), 184-194. Lippincott Williams & Wilkins
l -tryptophan induces IDO (indoleamine 2,3-dioxygenase) 1–dependent vasodilation. IDO1 is expressed in placental endothelial cells and downregulated in preeclampsia. Hypothesizing that this may contribute to diminished placental perfusion, we studi
Autor:
Langeza Saleh, Willy Visser, Jorie Versmissen, Anton H. van den Meiracker, Irwin K.M. Reiss, Emilie Hitzerd, A.H. Jan Danser, Rugina I. Neuman, Katrina M Mirabito Colafella
Publikováno v:
Clinical Science, 133(12), 1341-1352. Portland Press, Ltd.
Preeclampsia (PE) is a pregnancy complication, featuring elevated blood pressure and proteinuria, with no appropriate treatment. Activation of the endothelin system has emerged as an important pathway in PE pathophysiology based on experimental PE mo
Autor:
Daphne Merkus, A.H. Jan Danser, Sam Schoenmakers, Emilie Hitzerd, Rugina I. Neuman, Irwin K.M. Reiss, Michelle Broekhuizen, Katrina M Mirabito Colafella, Sinno H.P. Simons
Publikováno v:
Current Pharmaceutical Design, 25(5), 505-527. Bentham Science Publishers B.V.
Adequate development of the placenta is essential for optimal pregnancy outcome. Pre-eclampsia (PE) is increasingly recognized to be a consequence of placental dysfunction and can cause serious maternal and fetal complications during pregnancy. Furth
Autor:
Willy Visser, A.H. Jan Danser, Emilie Hitzerd, Anton H. van den Meiracker, Jorie Versmissen, Sam Schoenmakers, Birgit C. P. Koch, Rugina I. Neuman, Irwin K.M. Reiss, Sinno H.P. Simons, Michelle Broekhuizen
Publikováno v:
Hypertension, 75(3), 877-884. Lippincott Williams & Wilkins
Increasing evidence suggests a role for the ET (endothelin) system in preeclampsia. Hence, blocking this system with endothelin receptor antagonists (ERAs) could be a therapeutic strategy. Yet, clinical studies are lacking due to possible teratogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955aa591a0ff0f508320cf60f1e5b989
https://pure.eur.nl/en/publications/9f67181c-c8ff-4697-ad49-bc3704d98de9
https://pure.eur.nl/en/publications/9f67181c-c8ff-4697-ad49-bc3704d98de9
Autor:
A.H. Jan Danser, Emilie Hitzerd, Jorie Versmissen, Soma Bahmany, Daan van de Velde, Bart van Domburg, Birgit C. P. Koch
Publikováno v:
Biomedical Chromatography, 34. John Wiley & Sons Ltd.
Endothelin receptor antagonists (ERAs) such as, ambrisentan, macitentan and sitaxentan are primarily used for the treatment of pulmonary arterial hypertension. Considering the rise in endothelin in pre-eclampsia, ERAs may also be useful in its treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b805eca28f871266071f5dd4da87675
https://pure.eur.nl/en/publications/6f90be51-3974-452e-95cb-84f50f090487
https://pure.eur.nl/en/publications/6f90be51-3974-452e-95cb-84f50f090487