Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Emilie Heckel"'
Autor:
Claudia Dominici, Oscar D Villarreal, Junio Dort, Emilie Heckel, Yu Chang Wang, Ioannis Ragoussis, Jean-Sebastien Joyal, Nicolas Dumont, Stéphane Richard
Publikováno v:
eLife, Vol 12 (2023)
In skeletal muscle, muscle stem cells (MuSC) are the main cells responsible for regeneration upon injury. In diseased skeletal muscle, it would be therapeutically advantageous to replace defective MuSCs, or rejuvenate them with drugs to enhance their
Externí odkaz:
https://doaj.org/article/f457c027fbc9429c8371d06ee36f86bb
Autor:
Masayuki Hata, Maki Hata, Elisabeth M.M.A. Andriessen, Rachel Juneau, Frédérique Pilon, Sergio Crespo-Garcia, Roberto Diaz-Marin, Vera Guber, Francois Binet, Frédérik Fournier, Manuel Buscarlet, Caroline Grou, Virginie Calderon, Emilie Heckel, Heather J. Melichar, Jean-Sebastien Joyal, Ariel M. Wilson, Przemyslaw Sapieha
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Pathological neovascularization in age-related macular degeneration (nvAMD) drives the principal cause of blindness in the elderly. While there is a robust genetic association between genes of innate immunity and AMD, genome-to-phenome relationships
Externí odkaz:
https://doaj.org/article/9f2a87e18ff945d5802827bcdccf47e0
Autor:
Emilie Heckel, Gael Cagnone, Tapan Agnihotri, Bertan Cakir, Ashim Das, Jin Sung Kim, Nicholas Kim, Geneviève Lavoie, Anu Situ, Sheetal Pundir, Ye Sun, Florian Wünnemann, Kerry A. Pierce, Courtney Dennis, Grant A. Mitchell, Sylvain Chemtob, Flavio A. Rezende, Gregor Andelfinger, Clary B. Clish, Philippe P. Roux, Przemyslaw Sapieha, Lois E.H. Smith, Jean-Sébastien Joyal
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Dyslipidemia and autophagy have been implicated in the pathogenesis of blinding neovascular age-related macular degeneration (NV-AMD). VLDL receptor (VLDLR), expressed in photoreceptors with a high metabolic rate, facilitates the uptake of triglyceri
Externí odkaz:
https://doaj.org/article/2daa7b5d47564630a41d65386cd0a30f
Autor:
Ahmad Sharanek, Audrey Burban, Matthew Laaper, Emilie Heckel, Jean-Sebastien Joyal, Vahab D. Soleimani, Arezu Jahani-Asl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The suppression of the receptor for oncostatin M (OSMR) can prevent glioblastoma cell growth. Here, the authors demonstrate a role for OSMR in modulating glioma stem cell respiration and its impact on resistance to ionizing radiation.
Externí odkaz:
https://doaj.org/article/07ab77c522f840c99b21baeb5d12a073
Autor:
Zhongjie Fu, Chuck T Chen, Gael Cagnone, Emilie Heckel, Ye Sun, Bertan Cakir, Yohei Tomita, Shuo Huang, Qian Li, William Britton, Steve S Cho, Timothy S Kern, Ann Hellström, Jean‐Sébastien Joyal, Lois EH Smith
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
Abstract The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are con
Externí odkaz:
https://doaj.org/article/3333c50737c84adcb56dde89bc82b7e9
Autor:
Masayuki Hata, Elisabeth M. M. A. Andriessen, Maki Hata, Roberto Diaz-Marin, Frédérik Fournier, Sergio Crespo-Garcia, Guillaume Blot, Rachel Juneau, Frédérique Pilon, Agnieszka Dejda, Vera Guber, Emilie Heckel, Caroline Daneault, Virginie Calderon, Christine Des Rosiers, Heather J. Melichar, Thomas Langmann, Jean-Sebastien Joyal, Ariel M. Wilson, Przemyslaw Sapieha
Publikováno v:
Science (New York, N.Y.). 379(6627)
Age-related macular degeneration is a prevalent neuroinflammatory condition and a major cause of blindness driven by genetic and environmental factors such as obesity. In diseases of aging, modifiable factors can be compounded over the life span. We
Autor:
Arezu Jahani-Asl, Ahmad Sharanek, Emilie Heckel, Matthew Laaper, Audrey Burban, Vahab D. Soleimani, Jean-Sébastien Joyal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Glioblastoma contains a rare population of self-renewing brain tumor stem cells (BTSCs) which are endowed with properties to proliferate, spur the growth of new tumors, and at the same time, evade ionizing radiation (IR) and chemotherapy. However, th
Autor:
Alexandra Beaudry-Richard, Alexandre Beaulac, Estefania Marin Sierra, Jose-Carlos Rivera, David M. Olson, Kristina M. Adams Waldorf, Sheetal Pundir, Sylvain Chemtob, Mohammad Ali Mohammad Nezhady, Ankush Madaan, Mathieu Nadeau-Vallée, Gregory A. Lodygensky, William D. Lubell, Élizabeth Prairie, Amarilys Boudreault, Jean-François Bouchard, Xin Hou, Emilie Heckel, Sarah A. Robertson, Christiane Quiniou, Noémie Maurice, Jean-Sébastien Joyal, Jeffrey A. Keelan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Antenatal inflammation as seen with chorioamnionitis is harmful to foetal/neonatal organ development including to eyes. Although the major pro-inflammatory cytokine IL-1β participates in retinopathy induced by hyperoxia (a predisposing factor to ret
Autor:
Timothy S. Kern, Gael Cagnone, Zhongjie Fu, Jean-Sébastien Joyal, Shuo Huang, Qian Li, Yohei Tomita, Chuck T. Chen, Bertan Cakir, Steve S Cho, Emilie Heckel, Ann Hellström, Ye Sun, William Britton, Lois E.H. Smith
Publikováno v:
EMBO molecular medicine, vol 11, iss 10
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
EMBO Molecular Medicine
The light‐sensitive photoreceptors in the retina are extremely metabolically demanding and have the highest density of mitochondria of any cell in the body. Both physiological and pathological retinal vascular growth and regression are controlled b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b49f9078347bd1f5c2cb4a83eacfa7
https://escholarship.org/uc/item/6g2249rq
https://escholarship.org/uc/item/6g2249rq
Autor:
Simon Brais-Brunet, Caroline Boudoux, Sylvain Chemtob, Emilie Heckel, Mathieu Dehaes, Udayakumar Kanniyappan, Jean-Sébastien Joyal
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The purpose of this study was to develop an in vivo optical coherence tomography (OCT) system capable of imaging the developing mouse retina and its associated morphometric and microstructural changes. Methods Thirty-four wild-type mice (129S