Experimental and modeling study of the formation of cell aggregates with differential substrate adhesion.

Autor: Léo Adenis, Emilie Gontran, Christophe Deroulers, Basile Grammaticos, Marjorie Juchaux, Olivier Seksek, Mathilde Badoual

Publikováno v: PLoS ONE, Vol 15, Iss 2, p e0222371 (2020)

The study of cell aggregation in vitro has a tremendous importance these days. In cancer biology, aggregates and spheroids serve as model systems and are considered as pseudo-tumors that are more realistic than 2D cell cultures. Recently, in the cont

Externí odkaz: https://doaj.org/article/7676cf877df2435eb2c9c342016d2964

Self-Organogenesis from 2D Micropatterns to 3D Biomimetic Biliary Trees

Autor: Emilie Gontran, Lorena Loarca, Cyrille El Kassis, Latifa Bouzhir, Dmitry Ayollo, Elsa Mazari-Arrighi, Alexandra Fuchs, Pascale Dupuis-Williams

Publikováno v: Bioengineering, Vol 8, Iss 8, p 112 (2021)

Background and Aims: Globally, liver diseases account for 2 million deaths per year. For those with advanced liver disease the only curative approach is liver transplantation. However, less than 10% of those in need get a liver transplant due to limi

Externí odkaz: https://doaj.org/article/fae28074fb144739b7b0964ae576e836

Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments

Autor: Diane-Laure Pagès, Emmanuel Dornier, Jean de Seze, Emilie Gontran, Ananyo Maitra, Aurore Maciejewski, Li Wang, Rui Luan, Jérôme Cartry, Charlotte Canet-Jourdan, Joël Raingeaud, Grégoire Lemahieu, Marceline Lebel, Michel Ducreux, Maximiliano Gelli, Jean-Yves Scoazec, Mathieu Coppey, Raphaël Voituriez, Matthieu Piel, Fanny Jaulin

Publikováno v: Science Advances
Science Advances, 2022, 8 (39), eabp8416. ⟨10.1126/sciadv.abp8416⟩

International audience; Cell migration is essential to living organisms and deregulated in cancer. Single cell’s migration ranges from traction-dependent mesenchymal motility to contractility-driven propulsive amoeboid locomotion, but collective ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e68cbadb699b79522aa613ef14452e
https://doi.org/10.1126/sciadv.abp8416

Generation and Quantitative Characterization of Functional and Polarized Biliary Epithelial Cysts

Autor: Mauricette Collado-Hilly, Pascale Dupuis-Williams, Emilie Gontran, Latifa Bouzhir, Lorena Loarca

Publikováno v: Journal of visualized experiments : JoVE. (159)

Cholangiocytes, the epithelial cells that line up the bile ducts in the liver, oversee bile formation and modification. In the last twenty years, in the context of liver diseases, 3-dimensional (3D) models based on cholangiocytes have emerged such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe62012a24d06088c5697ae9dbf4097
https://pubmed.ncbi.nlm.nih.gov/32478726

Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography

Autor: Auriane Marret, Elsa Mazari-Arrighi, Wissam Farhat, Emilie Gontran, Jérôme Larghero, Francois Chatelain, Alexandra Fuchs, Pascale Dupuis-Williams, Dmitry Ayollo

Publikováno v: Biomaterials
Biomaterials, Elsevier, 2021, 279, pp.121207. ⟨10.1016/j.biomaterials.2021.121207⟩
Biomaterials, 2021, 279, pp.121207. ⟨10.1016/j.biomaterials.2021.121207⟩

Cholangiocytes, biliary epithelial cells, are known to spontaneously self-organize into spherical cysts with a central lumen. In this work, we explore a promising biocompatible stereolithographic approach to encapsulate cholangiocytes into geometrica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a370fb09fd0ccd1e71958ef65cad0c03
https://doi.org/10.1016/j.biomaterials.2021.121207