A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals

Autor: Jonas Brorson Jensen, Ole L. Dollerup, Andreas B. Møller, Tine B. Billeskov, Emilie Dalbram, Sabina Chubanava, Mads V. Damgaard, Ryan W. Dellinger, Kajetan Trošt, Thomas Moritz, Steffen Ringgaard, Niels Møller, Jonas T. Treebak, Jean Farup, Niels Jessen

Publikováno v: JCI Insight, Vol 7, Iss 19 (2022)

BACKGROUND During aging, there is a functional decline in the pool of muscle stem cells (MuSCs) that influences the functional and regenerative capacity of skeletal muscle. Preclinical evidence has suggested that nicotinamide riboside (NR) and pteros

Externí odkaz: https://doaj.org/article/614077a593674c7a8b1130bb651c388e

Cytosolic ROS production by NADPH oxidase 2 regulates muscle glucose uptake during exercise

Autor: Carlos Henríquez-Olguin, Jonas R. Knudsen, Steffen H. Raun, Zhencheng Li, Emilie Dalbram, Jonas T. Treebak, Lykke Sylow, Rikard Holmdahl, Erik A. Richter, Enrique Jaimovich, Thomas E. Jensen

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Reactive oxygen species (ROS) stimulate GLUT4-mediated glucose transport following contraction of isolated muscle, but it is not clear if this occurs in vivo. Here, the authors show in human volunteers that exercise induces ROS increase in muscle and

Externí odkaz: https://doaj.org/article/a635b493f521447c82852adb296d2252

NAMPT-dependent NAD + biosynthesis controls circadian metabolism in a tissue-specific manner

Autor: Astrid L. Basse, Karen N. Nielsen, Iuliia Karavaeva, Lars R. Ingerslev, Tao Ma, Jesper F. Havelund, Thomas S. Nielsen, Mikkel Frost, Julia Peics, Emilie Dalbram, Morten Dall, Juleen R. Zierath, Romain Barrès, Nils J. Færgeman, Jonas T. Treebak, Zachary Gerhart-Hines

Publikováno v: Basse, A L, Nielsen, K N, Karavaeva, I, Ingerslev, L R, Ma, T, Havelund, J F, Nielsen, T S, Frost, M, Peics, J, Dalbram, E, Dall, M, Zierath, J R, Barrès, R, Færgeman, N J, Treebak, J T & Gerhart-Hines, Z 2023, ' NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 14, e2220102120 . https://doi.org/10.1073/pnas.2220102120

Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating input from the hypothalamic master clock and intracellular metabolic signals. One such key metabolic signal is the cellular concentration of NAD + , which os

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c273dfdf97b93fab97fdc623e5cb7f38
https://doi.org/10.1073/pnas.2220102120

Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity

Autor: Romain Barrès, Jean Farup, Steen Larsen, Michael Kjaer, Jonas Jensen, Niels Jessen, Morten Dall, Amy M. Ehrlich, Thomas Krag, Niels Ørtenblad, Ali Altıntaş, Anders Karlsen, Jonas T. Treebak, John Vissing, Roldan M. de Guia, Emilie Dalbram, Andreas Buch Møller, Astrid L. Basse, Santina Bruzzone, Marianne Agerholm, Joachim Nielsen

Publikováno v: Basse, A L, Agerholm, M, Farup, J, Dalbram, E, Nielsen, J, Ørtenblad, N, Altıntaş, A, Ehrlich, A M, Krag, T, Bruzzone, S, Dall, M, de Guia, R M, Jensen, J B, Møller, A B, Karlsen, A, Kjær, M, Barrès, R, Vissing, J, Larsen, S, Jessen, N & Treebak, J T 2021, ' Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity ', Molecular Metabolism, vol. 53, 101271 . https://doi.org/10.1016/j.molmet.2021.101271
Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101271-(2021)

Objective NAD+ is a co-factor and substrate for enzymes maintaining energy homeostasis. Nicotinamide phosphoribosyltransferase (NAMPT) controls NAD+ synthesis, and in skeletal muscle, NAD+ is essential for muscle integrity. However, the underlying mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efcd340442946122eebe8ae09ba75a2
https://pure.au.dk/portal/da/publications/nampt-controls-skeletal-muscle-development-by-maintaining-ca2-homeostasis-and-mitochondrial-integrity(4741a3f5-2578-476d-9226-4ae5353491ea).html

Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action

Autor: Juleen R. Zierath, Astrid L. Basse, Jonas T. Treebak, Emilie Dalbram

Publikováno v: Dalbram, E, Basse, A L, Zierath, J R & Treebak, J T 2019, ' Voluntary wheel running in the late dark phase ameliorates diet-induced obesity in mice without altering insulin action ', Journal of Applied Physiology, vol. 126, no. 4, pp. 993-1005 . https://doi.org/10.1152/japplphysiol.00737.2018

Metabolic dysfunction and Type 2 diabetes are associated with perturbed circadian rhythms. However, exercise appears to ameliorate circadian disturbances, as it can phase-shift or reset the internal clock system. Evidence is emerging that exercise at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9511aa7e1bb5e84fdf5ba8fbf530cf3e
https://doi.org/10.1152/japplphysiol.00737.2018