Synthesis of novel C-nucleoside analogues bearing an anomeric cyano and a 1,2,3-triazole nucleobase as potential antiviral agents

Autor: Pierre Sierocki, Krystal Gaillard, Ruben Arturo Arellano Reyes, Chloé Donnart, Emilie Lambert, Sandrine Grosse, Laurence Arzel, Arnaud Tessier, Jerome Guillemont, Monique Mathé-Allainmat, Jacques Lebreton

Publikováno v: Organic & Biomolecular Chemistry. 20:2715-2728

We report the synthesis of C-nucleosides with a quaternary carbon at the anomeric position tethered to a 4-substituted 1,2,3-triazole ring and a cyano group, which were developed as potential antiviral agents.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5808d33064b0cdee660e899626f0b203
https://doi.org/10.1039/d1ob02451e

From Oxygen to Sulfur and Back: Difluoro -H-phosphinothioates as a Turning Point in the Preparation of Difluorinated Phosphinates: Application to the Synthesis of Modified Dinucleotides

Autor: Emilie Lambert, Pauline Remy, Julien Brioche, Jun Zhang, Ze-Feng Xu, Serge R. Piettre

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (9), pp.5245-5260. ⟨10.1021/acs.joc.9b00232⟩

International audience; A simple, two-step procedure to convert α,α-difluorinated H-phosphinic acids into the corresponding H-phosphinothioates is described. The usefulness of these species is demonstrated by their transformation into difluorinated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ce39e62366b7add225c8fa82522d0f
https://pubmed.ncbi.nlm.nih.gov/30946780

Diastereoselective Access to Enantiomerically Pure cis-2,3-Disubstituted Pyrrolidines

Autor: Jean-Luc Vasse, Jan Szymoniak, Pierre-Olivier Delaye, Tarun K. Pradhan, Emilie Lambert

Publikováno v: European Journal of Organic Chemistry. 2010:3395-3406

A straightforward access to enantiomerically pure 2,3-disubstituted pyrrolidines is reported that involves diastereoselective allylation of (R)-phenylglycinol-derived imines and a sequential hydrozirconation-cyclization. A number of pyrrolidine deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22afd0c1c4d9c5a42c8ebe470034c9d2
https://doi.org/10.1002/ejoc.201000255

Diastereoselective access to trans-2-substituted cyclopentylamines

Autor: Antoine Joosten, Jan Szymoniak, Emilie Lambert, Jean-Luc Vasse

Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2010, 12 (22), pp.5128-5131. ⟨10.1021/ol102038x⟩

International audience; A highly diastereoselective synthesis of trans-2-substituted cyclopentylamines via a tandem hydrozirconation/Lewis acid-mediated cyclization sequence applied to butenyl oxazolidines is described. The method allows an easy prep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306b75ecc900f0db566b3134c0349ffc
https://pubmed.ncbi.nlm.nih.gov/20954729