Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR

Autor: Emilie, Hangen, Fabrice P, Cordelières, Jennifer D, Petersen, Daniel, Choquet, Françoise, Coussen

Publikováno v: Cell Reports

Summary Regulation of AMPA receptor (AMPAR) trafficking is a key modulator of excitatory synaptic transmission; however, intracellular vesicular transport of newly synthesized AMPARs has been little studied due to technical limitations. By combining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc35b399523cb63266d5272536928211
https://pubmed.ncbi.nlm.nih.gov/30044968

Huntingtin proteolysis releases non‐polyQ fragments that cause toxicity through dynamin 1 dysregulation

Autor: Marie‐Thérèse El‐Daher, Sandrine Lévêque-Fort, Juan Botas, Ismael Al-Ramahi, Emilie Hangen, Ghislaine Poizat, Raul Pardo, Julie Bruyère, Sandrine Humbert, Nicolas Bourg, Sylvie Souquere, Gérard Pierron, Frédéric Saudou, Céline Mayet

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2015, 34 (17), pp.2255-2271. ⟨10.15252/embj.201490808⟩
EMBO Journal, 2015, 34 (17), pp.2255-2271. ⟨10.15252/embj.201490808⟩

International audience; Cleavage of mutant huntingtin (HTT) is an essential process in Huntington's disease (HD), an inherited neurodegenerative disorder. Cleavage generates N-ter fragments that contain the polyQ stretch and whose nuclear toxicity is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a34309be7a95cc6aa051b31fa90b3d
https://hal.archives-ouvertes.fr/hal-03297282

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis

Autor: Olivier Feraud, Fabiola Ciccosanti, Stephane Flamant, Annelise Bennaceur-Griscelli, Isabelle Godin, Kevin Müller, Karine Ser-Le Roux, Changlian Zhu, Kostas Tokatlidis, Gian Maria Fimia, Esther Nuebel, Menotti Ruvo, Jean-Luc Perfettini, Mauro Piacentini, Emilie Hangen, Haiwei Mou, Allan Sauvat, Patrick Gonin, Paule Bénit, Nunzianna Doti, Pierre Rustin, Ngoc vy Lam, Klas Blomgren, Afroditi Chatzi, Sylvie Lachkar, Guido Kroemer, Nazanine Modjtahedi

Publikováno v: Molecular cell (Online) (2015).
info:cnr-pdr/source/autori:Hangen E1, Féraud O2, Lachkar S1, Mou H1, Doti N3, Fimia GM4, Lam NV1, Zhu C5, Godin I6, Muller K1, Chatzi A7, Nuebel E7, Ciccosanti F8, Flamant S9, Bénit P10, Perfettini JL11, Sauvat A12, Bennaceur-Griscelli A13, Ser-Le Roux K14, Gonin P14, Tokatlidis K7, Rustin P10, Piacentini M15, Ruvo M3, Blomgren K16, Kroemer G17, Modjtahedi N18./titolo:Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis./doi:/rivista:Molecular cell (Online)/anno:2015/pagina_da:/pagina_a:/intervallo_pagine:/volume
Molecular Cell
Molecular Cell, Elsevier, 2015, 58 (6), pp.1001-1014. ⟨10.1016/j.molcel.2015.04.020⟩
Molecular Cell, 2015, 58 (6), pp.1001-1014. ⟨10.1016/j.molcel.2015.04.020⟩

Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, beyond its apoptotic function, is required for the normal expression of major respiratory chain complexes. Here we identified an AIF-interacting protein, CHCHD4, which is the centr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fcc8084734c5005015b7e3b2b087c2e
https://publications.cnr.it/doc/331007

A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2

Autor: Pierre Rustin, Klas Blomgren, Sylvie Lachkar, Guido Kroemer, A de Andrade, Carsten Culmsee, Nazanine Modjtahedi, Günter U. Höglinger, Gérard Pierron, Gian Maria Fimia, Vladimir Lazar, Matteo Bordi, Emilie Hangen, Francis Harper, Jose Miguel Vicencio, Jean Bénard, Paule Bénit, Mauro Piacentini, J-L Perfettini, Changlian Zhu, Philippe Dessen, D De Zio, F Caffin, Francesco Cecconi

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2010, 17 (7), pp.1155-1166. ⟨10.1038/cdd.2009.211⟩
Cell Death and Differentiation, 2010, 17, pp.1155-1166. ⟨10.1038/cdd.2009.211⟩
Cell Death and Differentiation, Nature Publishing Group, 2010, 17, pp.1155-1166. ⟨10.1038/cdd.2009.211⟩

International audience; Apoptosis-Inducing factor (AIF) plays important supportive as well as potentially lethal roles in neurons. Under normal physiological conditions, AIF is a vital redox-active mitochondrial enzyme, whereas in pathological situat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5b348a10b003c02258773997d95dd7
https://hal.archives-ouvertes.fr/hal-02356575

Methods to dissect mitochondrial membrane permeabilization in the course of apoptosis

Autor: Lorenzo, Galluzzi, Ilio, Vitale, Oliver, Kepp, Claire, Séror, Emilie, Hangen, Jean-Luc, Perfettini, Nazanine, Modjtahedi, Guido, Kroemer

Publikováno v: Methods in enzymology. 442

In several paradigms of cell death, mitochondrial membrane permeabilization (MMP) delimits the frontier between life and death. Mitochondria control the intrinsic pathway of apoptosis and participate in the extrinsic pathway. Moreover, they have been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b35927ad071c24e558453c58fb7286e
https://pubmed.ncbi.nlm.nih.gov/18662579