Transcriptional landscape of a RETC634Y-mutated iPSC and its CRISPR-corrected isogenic control reveals the putative role of EGR1 transcriptional program in the development of multiple endocrine neoplasia type 2A-associated cancers

Autor: Julien Hadoux, Christophe Desterke, Olivier Féraud, Mathieu Guibert, Roberta Francesca De Rose, Paule Opolon, Dominique Divers, Emilie Gobbo, Frank Griscelli, Martin Schlumberger, Annelise Bennaceur-Griscelli, Ali G. Turhan

Publikováno v: Stem Cell Research, Vol 26, Iss , Pp 8-16 (2018)

Summary: MEN2A is a hereditary cancer-predisposing syndrome that affects patients with germline RET mutations. The effects of this oncogenic tyrosine kinase in the context of primitive stem cells are not known. In order to study these events, we gene

Externí odkaz: https://doaj.org/article/6b8edb93b8224b969313efc275e52ecf

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines.

Autor: Olivier Féraud, Yannick Valogne, Michael W Melkus, Yanyan Zhang, Noufissa Oudrhiri, Rima Haddad, Aurélie Daury, Corinne Rocher, Aniya Larbi, Philippe Duquesnoy, Dominique Divers, Emilie Gobbo, Philippe Brunet de la Grange, Fawzia Louache, Annelise Bennaceur-Griscelli, Maria Teresa Mitjavila-Garcia

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0149291 (2016)

Hematopoiesis generated from human embryonic stem cells (ES) and induced pluripotent stem cells (iPS) are unprecedented resources for cell therapy. We compared hematopoietic differentiation potentials from ES and iPS cell lines originated from variou

Externí odkaz: https://doaj.org/article/14bfd02e2fb14211b51eee3337d975a5

Whole-genome analysis reveals unexpected dynamics of mutant subclone development in a patient with JAK2-V617F-positive chronic myeloid leukemia

Autor: Alexis Proust, Noufissa Oudrhiri, Ivan Sloma, Frank Griscelli, Marco A. Marra, Yusanna Ma, Ali G. Turhan, Christophe Desterke, Maria Teresa Mitjavila-Garcia, Martin Hirst, Dominique Divers, David M. Smadja, Olivier Feraud, Connie J. Eaves, Annelise Bennaceur-Griscelli, Annaick Carles, Emilie Gobbo, Sanaa El Marsafy

Publikováno v: Experimental Hematology. 53:48-58

We report here the first use of whole-genome sequencing (WGS) to examine the initial clonal dynamics in an unusual patient with chronic myeloid leukemia (CML), who presented in chronic phase (CP) with doubly marked BCR-ABL1+/JAK2V617F-mutant cells an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40e6005f7c2aef475d158ab0c86e471
https://doi.org/10.1016/j.exphem.2017.05.007

ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

Autor: Didier Sauvaire, Philippe M. Loiseau, Sabrina Kali, Rahima Yousfi, Pascal Clayette, Daniel Gillet, Céline Bouclier, Noël Tordo, Jérôme Laporte, Amélie Goudet, Goulven Merer, Roman Lopez, Michel R. Popoff, Sandrine Cojean, Valérie Pons, Céline Aubenque, Claire Boulogne, Emmanuel Lemichez, Annette Fischer, Jean-Christophe Cintrat, Laetitia Panigai, Yu Wu, Cynthia Gillet, Roger Le Grand, Thomas Rudel, Robert A. Davey, Julien Barbier, Jo-Ana Herweg, Emilie Gobbo

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.15567. ⟨10.1038/s41598-017-15466-7⟩
Scientific Reports, 2017, 7 (1), pp.15567. ⟨10.1038/s41598-017-15466-7⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Intracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that shou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bbdeb7abb18948ea072b7da556e2d4
https://hal-pasteur.archives-ouvertes.fr/pasteur-01675662/document

Morphological Analysis of Human Induced Pluripotent Stem Cells During Induced Differentiation and Reverse Programming

Autor: Anne-Marie Courtot, Aurélie Magniez, Noufissa Oudrhiri, Olivier Féraud, Josette Bacci, Emilie Gobbo, Stéphanie Proust, Ali G. Turhan, Annelise Bennaceur-Griscelli

Publikováno v: BioResearch Open Access, Vol 3, Iss 5, Pp 206-216 (2014)

The fine analysis of cell components during the generation of pluripotent cells and their comparison to bone fide human embryonic stem cells (hESCs) are valuable tools to understand their biological behavior. In this report, human mesenchymal cells (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::ecc40f9ed812ebd5e1fc7d389fdfa3c5
https://www.liebertpub.com/doi/full/10.1089/BIORES.2014.0028