FUS fibrillation occurs through a nucleation-based process below the critical concentration required for liquid–liquid phase separation

Autor: Emilie Bertrand, Clément Demongin, Ioana Dobra, Juan Carlos Rengifo-Gonzalez, Anastasia S. Singatulina, Maria V. Sukhanova, Olga I. Lavrik, David Pastré, Loic Hamon

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract FUS is an RNA-binding protein involved in familiar forms of ALS and FTLD that also assembles into fibrillar cytoplasmic aggregates in some neurodegenerative diseases without genetic causes. The self-adhesive prion-like domain in FUS generate

Externí odkaz: https://doaj.org/article/9379e4e83d2b416ebc9af2f57a01912f

Temperature-sensitive polypeptide brushes-coated mesoporous silica nanoparticles for dual-responsive drug release

Autor: Ying-Wei Yang, Emilie Bertrand, Xinghuo Wang, Rong Deng, Xiangshuai Li, Kamel Meguellati, Qiong Jia, Yahan Cui

Publikováno v: Chinese Chemical Letters. 30:2291-2294

A biopolymer-inorganic hybrid system (MSN@PBLGF) is designed and fabricated from mesoporous silica nanoparticles (MSNs) and folic acid (FA)-terminated temperature-sensitive synthetic polypeptide, i.e., poly(γ-benzyl- l -glutamate) (PBLG) derivative,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9964c9147ae42256076b86aaea85ba5f
https://doi.org/10.1016/j.cclet.2019.08.017

Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats

Autor: Agnes Chartier, Frédéric Buron, Liliana Boiaryna, Pakorn Tangpong, Aziz Ouach, Frederic Pin, Sylvain Routier, Denis Guilloteau, Emilie Bertrand, Jean-Bernard Deloye, Zuhal Gulhan, Nuno Rodrigues, Johnny Vercouillie, Guylène Page, Céline Mothes, Sophie Serrière, Nathalie Percina, Franck Suzenet, Sylvie Chalon

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 179, pp.449-469. ⟨10.1016/j.ejmech.2019.06.049⟩
European Journal of Medicinal Chemistry, 2019, 179, pp.449-469. ⟨10.1016/j.ejmech.2019.06.049⟩

In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with commercially available and home-made boron deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0914b3f04569040b60720ff93522728e
https://www.hal.inserm.fr/inserm-02458368

Design of α7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies

Autor: Jean-Bernard Deloye, Zuhal Gulhan, Frederic Pin, Denis Guilloteau, Emilie Bertrand, Céline Mothes, Sylvie Chalon, Sylvain Routier, Johnny Vercouillie, Franck Suzenet, Aziz Ouach

Publikováno v: European journal of medicinal chemistry. 107

We report here the synthesis of a large library of 1,2,3-triazole derivatives which were in vitro tested as α7 nAchR ligands. The SAR study revealed that several crucial factors are involved in the affinity of these compounds for α7 nAchR such as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deabb4d26bb1bbd8b2799220c1f3e06b
https://pubmed.ncbi.nlm.nih.gov/26580980

Gene transfer by chemical vectors, and endocytosis routes of polyplexes, lipoplexes and lipopolyplexes in a myoblast cell line

Autor: Philippe Guégan, Chantal Pichon, Tony Le Gall, Mathieu Mével, Mathieu Berchel, Paul-Alain Jaffrès, Patrick Midoux, Thierry Benvegnu, Pierre Lehn, Tristan Montier, Hervé Cheradame, Emilie Bertrand, Jean-Pierre Gomez, Bruno Pitard, Ludivine Billiet

Publikováno v: Biomaterials
Biomaterials, 2012, 33 (10), pp.2980-2990. ⟨10.1016/j.biomaterials.2011.12.027⟩
Biomaterials, Elsevier, 2012, 33 (10), pp.2980-2990. ⟨10.1016/j.biomaterials.2011.12.027⟩

International audience; Chemical vectors are widely developed for providing safe DNA delivery systems. It is well admitted that their endocytosis and intracellular trafficking are critical for the transfection efficiency. Here, we have compared the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c889668c9b0f0aeab69ca37e393441
https://hal.science/hal-00721795