Deagglomeration of DNA nanomedicine carriers using controlled ultrasonication

Autor: Beth A. Hinchliffe, Piers Turner, David J. H. Cant, Emiliana De Santis, Purnank Aggarwal, Rob Harris, David Templeton, Alex G. Shard, Mark Hodnett, Caterina Minelli

Publikováno v: Ultrasonics Sonochemistry, Vol 89, Iss , Pp 106141- (2022)

Control over the agglomeration state of manufactured particle systems for drug and oligonucleotide intracellular delivery is paramount to ensure reproducible and scalable therapeutic efficacy. Ultrasonication is a well-established mechanism for the d

Externí odkaz: https://doaj.org/article/feb3dcf8a7e94f63b09eea42f743ec28

Imaging and 3D Reconstruction of De Novo Peptide Capsids

Autor: Emiliana, De Santis, Maxim G, Ryadnov

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2208

Nanoscale systems encapsulating biomacromolecules hold promise for cell and gene therapies. Common issues hampering progress include polydispersity, heterogeneity in size and shape, agglomeration, and poor stability. Much attention is given to the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fdce479b77e708c2ac13ab3c2cfcd28e
https://pubmed.ncbi.nlm.nih.gov/32856261

Engineering Chirally Blind Protein Pseudocapsids into Antibacterial Persisters

Autor: Maxim G. Ryadnov, Smita B. Gunnoo, Franca Fraternali, Xiaoliang Ba, Mark A. Holmes, Emiliana De Santis, Helen Lewis, Ibolya E. Kepiro, Michael Shaw, Katharine Hammond, Urszula Łapińska, Stefano Pagliara, Irene Marzuoli, Bart W. Hoogenboom, Christian D. Lorenz

Publikováno v: Kepiro, I E, Marzuoli, I, Hammond, K, Ba, X, Lewis, H, Shaw, M, Gunnoo, S B, De Santis, E, Łapińska, U, Pagliara, S, Holmes, M A, Lorenz, C D, Hoogenboom, B W, Fraternali, F & Ryadnov, M G 2020, ' Engineering Chirally Blind Protein Pseudocapsids into Antibacterial Persisters ', ACS Nano, vol. 14, no. 2, pp. 1609-1622 . https://doi.org/10.1021/acsnano.9b06814

Antimicrobial resistance stimulates the search for antimicrobial forms that may be less subject to acquired resistance. Here we report a conceptual design of protein pseudocapsids exhibiting a broad spectrum of antimicrobial activities. Unlike conven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd239e06e6c0b17813655bfee76ba2c
https://www.repository.cam.ac.uk/handle/1810/301228

Imaging Protein Fibers at the Nanoscale and In Situ

Autor: Angelo Bella, Michael Shaw, Emiliana De Santis, Maxim G. Ryadnov

Publikováno v: Methods in Molecular Biology ISBN: 9781493978090

Protein self-assembly offers a rich repertoire of tools and technologies. However, despite significant progress in this area, a deterministic measure of the phenomenon, which might lead to predictable relationships between protein components, assembl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47bb1a627565f7a938081f9d0900daad
https://doi.org/10.1007/978-1-4939-7811-3_4

Peptide self-assembly for nanomaterials: the old new kid on the block

Autor: Emiliana De Santis, Maxim G. Ryadnov

Publikováno v: Chemical Society Reviews. 44:8288-8300

Peptide self-assembly is an increasingly attractive tool for nanomaterials. Perfected in biology peptide self-assembling systems have impacted on nearly any conceivable nanomaterial type. However, with all the information available to us commercialis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db79ab3bd8f9d70753e2aab3ae6cb742
https://doi.org/10.1039/c5cs00470e