Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Emilia Rivas"'
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Synthesis of glycosyl derivatives as dopamine prodrugs: interaction with glucose carrier GLUT-1Electronic supplementary information (ESI) available: experimental details for the preparation of all derivatives and biological assays. See http://www.rsc.org/suppdata/ob/b2/b212066f
Autor: Ofelia Nieto, Alfonso Fernández-Mayoralas, María L. de Ceballos, Emilia Rivas, José Angel Fontenla, Caridad Fernandez
Publikováno v: Organic & Biomolecular Chemistry. 1:767-771
Glucosyl dopamine (DA) derivatives may represent a new class of DA prodrugs that would interact with glucose transporter GLUT-1, present in the blood-brain barrier, and generate DA in the brain. Therefore, compounds bearing the sugar moiety linked to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99e870ad5cf3ff9e87351c5b1bd174bb
https://doi.org/10.1039/b212066f
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2
Synthesis and biological studies of glycosyl dopamine derivatives as potential antiparkinsonian agents
Autor: Caridad Fernandez, Ofelia Nieto, José Angel Fontenla, Emilia Rivas, Gisela Montenegro, Alfonso Fernández-Mayoralas
Publikováno v: Carbohydrate Research. 327:353-365
A new approach to deliver dopamine into the central nervous system, based on the use of D-glucose as transportable agent, has been studied. Glycosyl dopamine derivatives bearing the sugar moiety linked to either the amino group or the catechol ring o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037bc2488faa4b801472275cf3799092
https://doi.org/10.1016/s0008-6215(00)00073-2
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3
In vivo effects of new inhibitors of catechol-O -methyl transferase
Autor: Emilia Rivas, José Angel Fontenla, Ofelia Nieto, María L. de Ceballos
Publikováno v: British Journal of Pharmacology. 126:1667-1673
1. The effects of two new synthetic compounds showing in vitro catechol-O-methyl transferase (COMT) inhibitor properties were studied in vivo and compared with the effects of nitecapone and Ro-41-0960. 2. QO IA (3-(3-hydroxy-4-methoxy-5-nitrobenzylid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9c6a0f2793d7841a997024fc3c41453
https://doi.org/10.1038/sj.bjp.0702474
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5
ChemInform Abstract: Synthesis and Biological Studies of Glycosyl Dopamine Derivatives as Potential Antiparkinsonian Agents
Autor: Emilia Rivas, José Angel Fontenla, Ofelia Nieto, Gisela Montenegro, Alfonso Fernández-Mayoralas, Caridad Fernandez
Publikováno v: ChemInform. 31
A new approach to deliver dopamine into the central nervous system, based on the use of D-glucose as transportable agent, has been studied. Glycosyl dopamine derivatives bearing the sugar moiety linked to either the amino group or the catechol ring o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e7d71dca2897f8fc2c557720c1440ec
https://doi.org/10.1002/chin.200046238
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6
Butyrophenone analogues in the carbazole series: synthesis and determination of affinities at D2 and 5-HT2A receptors
Autor: C. F. Masaguer, Enrique Raviña, María Isabel Loza, J. A. Fontenla, Emilia Rivas, Helena Tristán, Formoso E
Publikováno v: Bioorganicmedicinal chemistry letters. 8(24)
We describe a practical and efficient route for synthesis of 2-aminomethyl-1,2,3,9-tetrahydro-4H-carbazol-4-ones using an effective Fisher indole methodology. The most active compounds, 4b (QF 2003B) and 4c (QF 2004B), with pKi (5-HT2A/D2) ratio of 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66fb9c73285cea85b0d0101f2cdafba4
https://pubmed.ncbi.nlm.nih.gov/9934473
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7
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