Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Emilia Peuhu"'
Autor:
Johanna Lilja, Jasmin Kaivola, James R. W. Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R. Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D. Posada, Hellyeh Hamidi, Arafath K. Najumudeen, Owen J. Sansom, Igor L. Barsukov, Daniel Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The KRAS oncogene drives many common and highly fatal malignancies. These include pancreatic, lung, and colorectal cancer, where various activating KRAS mutations have made the development of KRAS inhibitors difficult. Here we identify the s
Externí odkaz:
https://doaj.org/article/aab4a06c715b4e4481e20d3e6037ab7e
Autor:
Oona Paavolainen, Markus Peurla, Leena M. Koskinen, Jonna Pohjankukka, Kamyab Saberi, Ella Tammelin, Suvi-Riitta Sulander, Masi Valkonen, Larissa Mourao, Pia Boström, Nina Brück, Pekka Ruusuvuori, Colinda L.G.J. Scheele, Pauliina Hartiala, Emilia Peuhu
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114837- (2024)
Summary: The major lactiferous ducts of the human breast branch out and end at terminal ductal lobular units (TDLUs). Despite their functional and clinical importance, the three-dimensional (3D) architecture of TDLUs has remained undetermined. Our qu
Externí odkaz:
https://doaj.org/article/4fcb5c262ff1458f9cfbb71c980860cf
Autor:
Hussein Al‐Akhrass, Mika Pietilä, Johanna Lilja, Ella‐Maria Vesilahti, Johanna M. Anttila, Heidi M. Haikala, Pauliina M. Munne, Juha Klefström, Emilia Peuhu, Johanna Ivaska
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 116-129 (2022)
In breast cancer, the currently approved anti‐receptor tyrosine‐protein kinase erbB‐2 (HER2) therapies do not fully meet the expected clinical goals due to therapy resistance. Identifying alternative HER2‐related therapeutic targets could off
Externí odkaz:
https://doaj.org/article/3226b21a139d4cb2aecf7f1e1b37a9ec
Autor:
Mika Pietilä, Pranshu Sahgal, Emilia Peuhu, Niklas Z. Jäntti, Ilkka Paatero, Elisa Närvä, Hussein Al-Akhrass, Johanna Lilja, Maria Georgiadou, Olav M. Andersen, Artur Padzik, Harri Sihto, Heikki Joensuu, Matias Blomqvist, Irena Saarinen, Peter J. Boström, Pekka Taimen, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The EGF receptor HER2 is an oncogene protein thought to reside at the plasma membrane, but its endosomal trafficking is currently unclear. Here, the authors report that HER2 is endocytosed and that sortillin-related receptor 1 (SORLA) promotes endoso
Externí odkaz:
https://doaj.org/article/b28b871b1d0643feb58c297bc60c61de
Autor:
Martina Lerche, Alberto Elosegui-Artola, Jenny Z. Kechagia, Camilo Guzmán, Maria Georgiadou, Ion Andreu, Donald Gullberg, Pere Roca-Cusachs, Emilia Peuhu, Johanna Ivaska
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101507- (2020)
Externí odkaz:
https://doaj.org/article/f402f066a5984586b01e9d2270d05f4c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/5a82d2326c6444069ee172827946b025
Autor:
Guillaume Jacquemet, Habib Baghirov, Maria Georgiadou, Harri Sihto, Emilia Peuhu, Pierre Cettour-Janet, Tao He, Merja Perälä, Pauliina Kronqvist, Heikki Joensuu, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Filopodia have a prominent role in driving cancer cell invasion. Here, the authors show that L-type calcium channels are a druggable target regulating filopodia stability and maturation into focal adhesions in metastatic breast cancer cells.
Externí odkaz:
https://doaj.org/article/c0c5390a16a0498f861b5ea72324fa6a
Autor:
Emilia Peuhu, Siiri I Salomaa, Nicola De Franceschi, Christopher S Potter, John P Sundberg, Jeroen Pouwels
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186628 (2017)
SHARPIN (Shank-Associated RH Domain-Interacting Protein) is a component of the linear ubiquitin chain assembly complex (LUBAC), which enhances TNF-induced NF-κB activity. SHARPIN-deficient (Sharpincpdm/cpdm) mice display multi-organ inflammation and
Externí odkaz:
https://doaj.org/article/d6787d0b25c04ad189f33de6e067239d
Autor:
Nicola De Franceschi, Emilia Peuhu, Maddy Parsons, Sami Rissanen, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska, Jeroen Pouwels
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143423 (2015)
SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of the linear ubiquitin chain assembly complex (
Externí odkaz:
https://doaj.org/article/53e347ddde994722a02692ca70f9dc62
Autor:
Jukka Westermarck, Pirjo Laakkonen, Anthony J. Chalmers, John Eriksson, Hannu Haapasalo, Olayinka Raheem, Shafiq U. Ahmed, Emilia Peuhu, Mikael Jumppanen, Xi Qiao, Oxana V. Denisova, Amanpreet Kaur
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b72f08ef31c3e574c926ed19dcb2bd1
https://doi.org/10.1158/0008-5472.22413792.v1
https://doi.org/10.1158/0008-5472.22413792.v1
