Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Emilia Peuhu"'
Autor:
Hussein Al‐Akhrass, Mika Pietilä, Johanna Lilja, Ella‐Maria Vesilahti, Johanna M. Anttila, Heidi M. Haikala, Pauliina M. Munne, Juha Klefström, Emilia Peuhu, Johanna Ivaska
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 116-129 (2022)
In breast cancer, the currently approved anti‐receptor tyrosine‐protein kinase erbB‐2 (HER2) therapies do not fully meet the expected clinical goals due to therapy resistance. Identifying alternative HER2‐related therapeutic targets could off
Externí odkaz:
https://doaj.org/article/3226b21a139d4cb2aecf7f1e1b37a9ec
Autor:
Mika Pietilä, Pranshu Sahgal, Emilia Peuhu, Niklas Z. Jäntti, Ilkka Paatero, Elisa Närvä, Hussein Al-Akhrass, Johanna Lilja, Maria Georgiadou, Olav M. Andersen, Artur Padzik, Harri Sihto, Heikki Joensuu, Matias Blomqvist, Irena Saarinen, Peter J. Boström, Pekka Taimen, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The EGF receptor HER2 is an oncogene protein thought to reside at the plasma membrane, but its endosomal trafficking is currently unclear. Here, the authors report that HER2 is endocytosed and that sortillin-related receptor 1 (SORLA) promotes endoso
Externí odkaz:
https://doaj.org/article/b28b871b1d0643feb58c297bc60c61de
Autor:
Martina Lerche, Alberto Elosegui-Artola, Jenny Z. Kechagia, Camilo Guzmán, Maria Georgiadou, Ion Andreu, Donald Gullberg, Pere Roca-Cusachs, Emilia Peuhu, Johanna Ivaska
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101507- (2020)
Externí odkaz:
https://doaj.org/article/f402f066a5984586b01e9d2270d05f4c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/5a82d2326c6444069ee172827946b025
Autor:
Guillaume Jacquemet, Habib Baghirov, Maria Georgiadou, Harri Sihto, Emilia Peuhu, Pierre Cettour-Janet, Tao He, Merja Perälä, Pauliina Kronqvist, Heikki Joensuu, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Filopodia have a prominent role in driving cancer cell invasion. Here, the authors show that L-type calcium channels are a druggable target regulating filopodia stability and maturation into focal adhesions in metastatic breast cancer cells.
Externí odkaz:
https://doaj.org/article/c0c5390a16a0498f861b5ea72324fa6a
Autor:
Emilia Peuhu, Siiri I Salomaa, Nicola De Franceschi, Christopher S Potter, John P Sundberg, Jeroen Pouwels
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186628 (2017)
SHARPIN (Shank-Associated RH Domain-Interacting Protein) is a component of the linear ubiquitin chain assembly complex (LUBAC), which enhances TNF-induced NF-κB activity. SHARPIN-deficient (Sharpincpdm/cpdm) mice display multi-organ inflammation and
Externí odkaz:
https://doaj.org/article/d6787d0b25c04ad189f33de6e067239d
Autor:
Nicola De Franceschi, Emilia Peuhu, Maddy Parsons, Sami Rissanen, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska, Jeroen Pouwels
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143423 (2015)
SHANK-associated RH domain interactor (SHARPIN) inhibits integrins through interaction with the integrin α-subunit. In addition, SHARPIN enhances nuclear factor-kappaB (NF-κB) activity as a component of the linear ubiquitin chain assembly complex (
Externí odkaz:
https://doaj.org/article/53e347ddde994722a02692ca70f9dc62
Autor:
Jukka Westermarck, Pirjo Laakkonen, Anthony J. Chalmers, John Eriksson, Hannu Haapasalo, Olayinka Raheem, Shafiq U. Ahmed, Emilia Peuhu, Mikael Jumppanen, Xi Qiao, Oxana V. Denisova, Amanpreet Kaur
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b72f08ef31c3e574c926ed19dcb2bd1
https://doi.org/10.1158/0008-5472.22413792.v1
https://doi.org/10.1158/0008-5472.22413792.v1
Autor:
Jukka Westermarck, Pirjo Laakkonen, Anthony J. Chalmers, John Eriksson, Hannu Haapasalo, Olayinka Raheem, Shafiq U. Ahmed, Emilia Peuhu, Mikael Jumppanen, Xi Qiao, Oxana V. Denisova, Amanpreet Kaur
List of indolocarbazole staurosporine analogues, their primary target proteins, and status in the clinical trials for the indicated diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e520866adff69de42926553065dab57
https://doi.org/10.1158/0008-5472.22413783.v1
https://doi.org/10.1158/0008-5472.22413783.v1
Supplementary Figure S2 from PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells
Autor:
Jukka Westermarck, Pirjo Laakkonen, Anthony J. Chalmers, John Eriksson, Hannu Haapasalo, Olayinka Raheem, Shafiq U. Ahmed, Emilia Peuhu, Mikael Jumppanen, Xi Qiao, Oxana V. Denisova, Amanpreet Kaur
Clinically relevant kinase inhibitors display synthetic lethality in PME-1 depleted glioma cells. Supplementary figure related to Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea37412e8212eb6e3b84772b3145c79
https://doi.org/10.1158/0008-5472.22413807
https://doi.org/10.1158/0008-5472.22413807