Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Emilia Ottosson-Laakso"'
Autor:
Emilia Ottosson-Laakso, Tiinamaija Tuomi, Björn Forsén, Monika Gullström, Per-Henrik Groop, Leif Groop, Petter Vikman
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146114 (2016)
Familial renal glycosuria is an inherited disorder resulting in glucose excretion in the urine despite normal blood glucose concentrations. It is most commonly due to mutations in the SLC5A2 gene coding for the glucose transporter SGLT2 in the proxim
Externí odkaz:
https://doaj.org/article/6be0505ec8af4ebbb483557638a421bf
Autor:
Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Mark Ibberson, Michele Solimena, Piero Marchetti, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi B Prasad
Publikováno v:
Life Sci. All. 5:e202201376 (2022)
Characterization of gene expression in pancreatic islets and its alteration in type 2 diabetes (T2D) are vital in understanding islet function and T2D pathogenesis. We leveraged RNA sequencing and genome-wide genotyping in islets from 188 donors to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6838e3d4003c0960d52634bc747502c5
http://hdl.handle.net/10138/347726
http://hdl.handle.net/10138/347726
Autor:
Ola Hansson, Emilia Ottosson-Laakso, Anders Lindqvist, S. Chriett, Nils Wierup, Lena Eliasson, J.A. Martínez López, Gad Hatem, Leif Groop, Rashmi B. Prasad, Mia Abels, Anna Edlund, Olof Asplund, Liliya Shcherbina
Publikováno v:
Molecular and cellular endocrinology. 521
Here we show that scratch family transcriptional repressor 1 (SCRT1), a zinc finger transcriptional regulator, is a novel regulator of beta cell function. SCRT1 was found to be expressed in beta cells in rodent and human islets. In human islets, expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fa4fae0f805ba2dedaf3d0e1197f23
https://pubmed.ncbi.nlm.nih.gov/33309639
https://pubmed.ncbi.nlm.nih.gov/33309639
Autor:
Olof Asplund, Petter Storm, Vikash Chandra, Emilia Ottosson-Laakso, Gad Hatem, Dina Mansour-Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Claes Wollheim, Isabella Artner, Hindrik Mulder, Ola Hansson, Timo Otonkoski, Leif Groop, Rashmi B. Prasad, Human Tissue Laboratory at Lund Uni Centre
Publikováno v:
SSRN Electronic Journal.
Changes in the hormone-producing pancreatic islets are central culprits in type 2 diabetes (T2D) pathogenesis. Characterization of gene expression in islets how it is altered in T2D are therefore vital in understanding islet function and T2D pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66838b5ffecefbbf7f520310d0d1fac3
https://doi.org/10.2139/ssrn.3724972
https://doi.org/10.2139/ssrn.3724972
Autor:
Emma Ahlqvist, Nikolay Oskolkov, Ola Hansson, Leif Groop, Petter Storm, Petter Vikman, Ulrika Krus, Emilia Ottosson-Laakso, Rashmi B. Prasad, João Fadista
Publikováno v:
Diabetes. 66:3013-3028
Dysregulation of gene expression in islets from patients with type 2 diabetes (T2D) might be causally involved in the development of hyperglycemia, or it could develop as a consequence of hyperglycemia (i.e., glucotoxicity). To separate the genes tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fa641c3515bbf069ddabb814c3afdf
https://doi.org/10.2337/db17-0311
https://doi.org/10.2337/db17-0311
Autor:
Petter Vikman, Mahboubeh Daneshpajooh, Madhusudhan Bysani, Charlotte Ling, Annika Bagge, Hindrik Mulder, Lena Eliasson, Emilia Ottosson Laakso, Karl Bacos
Publikováno v:
Diabetologia
Aims/hypothesis Pancreatic beta cell dysfunction is a prerequisite for the development of type 2 diabetes. Histone deacetylases (HDACs) may affect pancreatic endocrine function and glucose homeostasis through alterations in gene regulation. Our aim w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9c052a77578d3efc513b6fc84ac7a1
https://doi.org/10.1007/s00125-016-4113-2
https://doi.org/10.1007/s00125-016-4113-2
Autor:
João Fadista, Isabella Artner, Alexander Balhuizen, Nils Wierup, Hedvig Bennet, Inês G. Mollet, Anya Medina, Lena Eliasson, Marloes Dekker-Nitert, Emilia Ottosson-Laakso, Annika Bagge, Cecilia Nagorny, Petter Vikman, Malin Fex
Publikováno v:
Diabetologia. 59:744-754
The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9acde60fc9ff6a0cb80d4212e33b5180
https://doi.org/10.1007/s00125-015-3847-6
https://doi.org/10.1007/s00125-015-3847-6
Autor:
Nils Wierup, Otonkoski T, Claes B. Wollheim, Ola Hansson, Dina Mansour-Aly, Olle Korsgren, Ulrika Krus, Chandra, Hindrik Mulder, Isabella Artner, Emilia Ottosson-Laakso, Leif Groop, Olof Asplund, Rashmi B. Prasad, Tiinamaija Tuomi, Erik Renström, Emma Ahlqvist, Gad Hatem, Petter Storm, Hazem Ibrahim
Changes in the hormone-producing pancreatic islets are central culprits in type 2 diabetes (T2D) pathogenesis. Characterization of gene expression in islets how it is altered in T2D are therefore vital in understanding islet function and T2D pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6de08e77dd4643a2cfee88c9099cd1
https://doi.org/10.1101/435743
https://doi.org/10.1101/435743
Autor:
Andreas Lindqvist, Olof Asplund, Emma Ahlqvist, Esa Laurila, Nils Wierup, Tiinamaija Tuomi, Peter Almgren, Jens J. Holst, Emily Sonestedt, Marju Orho-Melander, Ulrika Krus, Leif Groop, Peter M. Nilsson, Liisa Hakaste, Emilia Ottosson-Laakso, Rashmi B. Prasad, Olle Melander
Publikováno v:
Almgren, P, Lindqvist, A, Krus, U, Hakaste, L, Ottosson-Laakso, E, Asplund, O, Sonestedt, E, Prasad, R B, Laurila, E, Orho-Melander, M, Melander, O, Tuomi, T, Holst, J J, Nilsson, P M, Wierup, N, Groop, L & Ahlqvist, E 2017, ' Genetic determinants of circulating GIP and GLP-1 concentrations ', JCI insight, vol. 2, no. 21, e93306 . https://doi.org/10.1172/jci.insight.93306
The secretion of insulin and glucagon from the pancreas and the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) from the gastrointestinal tract is essential for glucose homeostasis. Several novel t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9730492c0d028350d4ca7aab1fcb81
https://doi.org/10.1172/jci.insight.93306
https://doi.org/10.1172/jci.insight.93306
Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes
Autor:
Muhmmad Omar-Hmeadi, Peng Yin, Petter Vikman, Sebastian Barg, Nikhil R. Gandasi, Emilia Ottosson Laakso
Publikováno v:
Cell metabolism. 27(2)
Glucose-stimulated insulin secretion is biphasic, with a rapid first phase and a slowly developing sustained second phase; both are disturbed in type 2 diabetes (T2D). Biphasic secretion results from vastly different release probabilities of individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3148fb356f35f087d84f9668922a4374
https://pubmed.ncbi.nlm.nih.gov/29414688
https://pubmed.ncbi.nlm.nih.gov/29414688