Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Emilia Neuwirt"'
Autor:
Arianna Colcerasa, Jelena Melesina, Patrick Moser, Anja Vogelmann, Florian Friedrich, Pavlos Tzortzoglou, Emilia Neuwirt, Manuela Sum, Lin Zhang, Elizabeth Ramos-Morales, Christophe Romier, Oliver Einsle, Eric Metzger, Roland Schüle, Olaf Gross, Wolfgang Sippl, Manfred Jung
The NAD+-dependent lysine deacylase Sirtuin2 (Sirt2) is involved in multiple pathological conditions, including cancer. Targeting Sirt2 has thus received an increased interest for therapeutic purpose, including the ortholog from Schistosoma mansoni (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14bc1d79ad63cc86730b8191549ebacd
https://doi.org/10.26434/chemrxiv-2023-7x8pz
https://doi.org/10.26434/chemrxiv-2023-7x8pz
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Svenja Wöhrle, Larissa Fischer, Anna Kostina, Stephan Flemming, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian N. Parker, Andreas Boettcher, Christopher J. Farady, Rebecca Kesselring, Christopher Berlin, Rolf Backofen, Marta Rodriguez-Franco, Clemens Kreutz, Marco Prinz, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Publikováno v:
Science Signaling. 16
Inflammasomes are intracellular protein complexes that promote an inflammatory host defense in response to pathogens and damaged or neoplastic tissues and are implicated in inflammatory disorders and therapeutic-induced toxicity. We investigated the
Publikováno v:
Current Opinion in Biotechnology. 68:300-309
The NLRP3 inflammasome is an important player in innate immunity and pathogenic inflammation. Numerous studies have implicated it in sensing endogenous danger signals, yet the precise mechanisms remain unknown. Here, we review the current knowledge o
Autor:
Emilia Neuwirt, Giovanni Magnani, Tamara Ćiković, Anna Kostina, Svenja Wöhrle, Stephan Flemming, Larissa Fischer, Nora J. Fischenich, Benedikt S. Saller, Oliver Gorka, Steffen Renner, Claudia Agarinis, Christian Parker, Andreas Boettcher, Christopher J. Farady, Rolf Backofen, Marta Rodriguez-Franco, Martina Tholen, Thomas Reinheckel, Thomas Ott, Christina J. Groß, Philipp J. Jost, Olaf Groß
Inflammasomes are intracellular protein complexes that control proteolytic maturation and secretion of inflammatory interleukin-1 (IL-1) family cytokines and are thus important in host defense. While some inflammasomes are activated simply by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91918a639a74468417a76d5d58c4b680
https://doi.org/10.1101/2022.02.19.480941
https://doi.org/10.1101/2022.02.19.480941
Autor:
Anja Vogelmann, Matthias Schiedel, Nathalie Wössner, Annika Merz, Daniel Herp, Sören Hammelmann, Arianna Colcerasa, Garrison Komaniecki, Jun Young Hong, Manuela Sum, Eric Metzger, Emilia Neuwirt, Lin Zhang, Oliver Einsle, Olaf Groß, Roland Schüle, Hening Lin, Wolfgang Sippl, Manfred Jung
Sirtuin2 (Sirt2) with its NAD+-dependent deacetylase and defatty-acylase activities plays a central role in the regulation of specific cellular functions. Dysregulation of Sirt2 activity has been associated with the pathogenesis of many diseases, thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5cbfc9db19d6fb0113ee2ff20e3e9f2
https://doi.org/10.26434/chemrxiv-2021-1r1dn
https://doi.org/10.26434/chemrxiv-2021-1r1dn
Publikováno v:
Nature Chemical Biology. 15:552-553
The NLRP3 inflammasome contributes to pathogenic inflammation in a broad range of diseases, making it a highly relevant drug target. Two studies published in this issue found an inhibitor of NLRP3 inflammasome activation to directly bind NLRP3 within