Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Emilia Naydenova"'
Autor:
Sirine Jaber, Veronica Nemska, Ivan Iliev, Elena Ivanova, Tsvetelina Foteva, Nelly Georgieva, Ivan Givechev, Dimiter Tanev, Emilia Naydenova, Dancho Danalev
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 37, Iss 1, Pp 151-158 (2023)
AbstractPeptides are a promising alternative of conventional medical drugs for the treatment of different diseases because they have no or have very few side effects owing to the natural mechanisms for their elimination. There are a lot of examples o
Externí odkaz:
https://doaj.org/article/82744efd46af481b8f88051466073c75
Autor:
Sirine Jaber, Yana Evstatieva, Veronica Nemska, Dilyana Nikolova, Emilia Naydenova, Nelly Georgieva, Dancho Danalev
Publikováno v:
Current Research in Biotechnology, Vol 8, Iss , Pp 100236- (2024)
Many microorganisms pose a threat to human health due to the ever-increasing bacterial resistance to conventional drugs. Nowadays, searching for new alternatives to conventional antibiotics to fight bacterial resistance is a main task. Thus, natural
Externí odkaz:
https://doaj.org/article/89a0042b278a4c98931a2c005d22d825
Autor:
Victoria Vitkova, Krassimira Antonova, Ognyan Petkov, Angelina Stoyanova-Ivanova, Sirine Jaber, Vladislava Ivanova, Emilia Naydenova, Dancho Danalev
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 340 (2024)
Background: Specifically designed peptide mimetics offer higher selectivity regarding their toxicity to mammalian cells. In addition to the α-helix conformation, the specific activity is related to the peptide’s ability to penetrate the cell membr
Externí odkaz:
https://doaj.org/article/33da95278e334599abcfb4d1b8652aea
Publikováno v:
Pharmacia, Vol 69, Iss 4, Pp 935-942 (2022)
Stress is known to exert an influence on neuroendocrine, autonomic, hormonal functioning. Various stress models have been reported to induce analgesia. This is a phenomenon, referred to as stress-induced analgesia (SIA). Nociceptin/Orphanin FQ(N/OFQ)
Externí odkaz:
https://doaj.org/article/717abab4da544e7aa534ce7df92243a4
Autor:
Kameliya Anichina, Anelia Mavrova, Dimitar Vuchev, Galya Popova-Daskalova, Giada Bassi, Arianna Rossi, Monica Montesi, Silvia Panseri, Filip Fratev, Emilia Naydenova
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1518 (2023)
Benzimidazole anthelmintic drugs hold promise for repurposing as cancer treatments due to their interference with tubulin polymerization and depolymerization, manifesting anticancer properties. We explored the potential of benzimidazole compounds wit
Externí odkaz:
https://doaj.org/article/e34ca2f2440e45e59d5be0c45e98282b
Autor:
Dancho Danalev, Ivan Iliev, Stefan Dobrev, Silvia Angelova, Stoiko Petrin, Tatyana Dzimbova, Elena Ivanova, Dessislava Borisova, Emilia Naydenova
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1123 (2023)
(1) Background: Hydrophobicity (or lipophilicity) is a limiting factor in the ability of molecules to pass through cell membranes and to perform their function. The ability to efficiently access cytosol is especially important when a synthetic compou
Externí odkaz:
https://doaj.org/article/d82a6f044e184e70acf75b75b677df3e
Autor:
Sirine Jaber, Veronica Nemska, Ivan Iliev, Elena Ivanova, Tsvetelina Foteva, Nelly Georgieva, Ivan Givechev, Emilia Naydenova, Veronika Karadjova, Dancho Danalev
Publikováno v:
Molecules, Vol 26, Iss 23, p 7321 (2021)
(1) Background: Peptides are good candidates for anticancer drugs due to their natural existence in the body and lack of secondary effects. (KLAKLAK)2 is an antimicrobial peptide that also shows good anticancer properties. (2) Methods: The Solid Phas
Externí odkaz:
https://doaj.org/article/d0e4992db759419e90a89c5fbbf8bfa5
Autor:
Sirine Jaber, Ivan Iliev, Tsvetelina Angelova, Veronica Nemska, Inna Sulikovska, Emilia Naydenova, Nelly Georgieva, Ivan Givechev, Ivo Grabchev, Dancho Danalev
Publikováno v:
Molecules, Vol 26, Iss 4, p 898 (2021)
(1) Background: (KLAKLAK)2 is a representative of the antimicrobial peptide group which also shows good anticancer properties. (2) Methods: Herein, we report synthesis using SPPS and characterization by HPLC/MS of a series of shortened analogues of (
Externí odkaz:
https://doaj.org/article/fd3ca816c03e4dc5b2cfac04c08eb05e
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 1, Pp o6-o6 (2010)
In the title compound, NH4+·C5H9NO5P−, the five-membered methyloxazolidin-2-one unit is disordered over two positions, the major component having a site occupancy of 0.832 (9). A three-dimensional network of O—H...O and N—H...O hydrogen bonds
Externí odkaz:
https://doaj.org/article/53b8176eb3cf4e63a16e86ca92a0c34d
Publikováno v:
Proceedings of the Bulgarian Academy of Sciences. 75:1428-1436
Peptide mimetics imitate natural peptides’ structure but they could be specifically designed to be more selective concerning their toxicity to mammalian cells. In most cases this specificity is due to their ability to form α-helix in amphipathic e