Metastasis of breast cancer to bones alters the tumor immune microenvironment

Autor: Xue Chao, Ying Zhang, Chengyou Zheng, Qitao Huang, Jiabin Lu, Emilia M. Pulver, Julia Houthuijzen, Stefan Hutten, Rongzhen Luo, Jiehua He, Peng Sun

Publikováno v: European Journal of Medical Research, Vol 28, Iss 1, Pp 1-9 (2023)

Abstract Background Bone is one of the most frequent sites for breast cancer metastasis. Breast cancer bone metastasis (BCBM) leads to skeletal morbidities including pain, fractures, and spinal compression, all of which severely impact quality of lif

Externí odkaz: https://doaj.org/article/4598911194934f28a32b463ae4c06fbd

Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer

Autor: Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, Ron D. Jachimowicz, Marieke van de Ven, Natalie Proost, Bjørn Siteur, Renske de Korte-Grimmerink, Peter Bouwman, Emilia M. Pulver, Roebi de Bruijn, Jörg Isensee, Tim Hucho, Gaurav Pandey, Maarten van Lohuizen, Peter Mallmann, Hans Christian Reinhardt, Jos Jonkers, Julian Puppe

Publikováno v: Breast Cancer Research, Vol 24, Iss 1, Pp 1-19 (2022)

Abstract Background The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the

Externí odkaz: https://doaj.org/article/9766126bd94646d0abb634dc3e2d1caa

Data from iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer

Autor: Sangeeta N. Bhatia, Tyler Jacks, William C. Hahn, Charles S. Fuchs, Brian M. Wolpin, Andrew J. Aguirre, Felicia Hsu, Emilia M. Pulver, Ester J. Kwon, Srivatsan Raghavan, Mandar D. Muzumdar, Liangliang Hao, Justin H. Lo

Pancreatic cancer is one of the leading causes of cancer-related death, with 5-year survival of 8.5%. The lack of significant progress in improving therapy reflects our inability to overcome the desmoplastic stromal barrier in pancreatic ductal adeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5466183ec078fe83137fdebb5b8615b6
https://doi.org/10.1158/1535-7163.c.6539331.v1

Data from A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair

Autor: Jos Jonkers, Peter Bouwman, Arnab Ray Chaudhuri, Haico van Attikum, Jeroen Essers, Dik C. van Gent, Bing Xia, Ivo J. Huijbers, Colin E.J. Pritchard, Marieke van de Ven, Renske de Korte-Grimmerink, Sjoerd Klarenbeek, Kerstin Hahn, Nicole S. Verkaik, Anne Paulien Drenth, Eline van der Burg, Maria Valeria Lattanzio, Roebi de Bruijn, Hanneke van der Gulden, Magdalena B. Rother, Stefan J. Roobol, Gerarda van de Kamp, Chirantani Mukherjee, Emilia M. Pulver

The BRCA1 tumor suppressor gene encodes a multidomain protein for which several functions have been described. These include a key role in homologous recombination repair (HRR) of DNA double-strand breaks, which is shared with two other high-risk her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::786ed1996ad6e1a9b8f8a8dc4137aca5
https://doi.org/10.1158/0008-5472.c.6513568.v1

A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair

Autor: Arnab Ray Chaudhuri, Jos Jonkers, Sjoerd Klarenbeek, Eline van der Burg, Bing Xia, Kerstin Hahn, Nicole S. Verkaik, Jeroen Essers, Haico van Attikum, Magdalena B. Rother, Colin Pritchard, Peter Bouwman, Hanneke van der Gulden, Chirantani Mukherjee, Emilia M. Pulver, Ivo J. Huijbers, Anne Paulien Drenth, Stefan J. Roobol, Roebi de Bruijn, Marieke van de Ven, Renske de Korte-Grimmerink, Maria Valeria Lattanzio, Gerarda van de Kamp, Dik C. van Gent

Publikováno v: Cancer Research, 81(24), 6171-6182. American Association for Cancer Research Inc.
Cancer Research, 81(24), 6171-6182. AMER ASSOC CANCER RESEARCH

The BRCA1 tumor suppressor gene encodes a multidomain protein for which several functions have been described. These include a key role in homologous recombination repair (HRR) of DNA double-strand breaks, which is shared with two other high-risk her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b78fbb36a46387ef6ac760f80bcf66
https://doi.org/10.1158/0008-5472.can-21-1415