Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Emilia M Swietlik"'
Autor:
Anna Ulrich, Yukyee Wu, Harmen Draisma, John Wharton, Emilia M. Swietlik, Inês Cebola, Eleni Vasilaki, Zhanna Balkhiyarova, Marjo-Riitta Jarvelin, Juha Auvinen, Karl-Heinz Herzig, J. Gerry Coghlan, James Lordan, Colin Church, Luke S. Howard, Joanna Pepke-Zaba, Mark Toshner, Stephen J. Wort, David G. Kiely, Robin Condliffe, Allan Lawrie, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Pulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA variants influence PAH risk, but susceptibility from epigenetic changes is unknown. We
Externí odkaz:
https://doaj.org/article/8e50277bf2c448aa930fb3478374f053
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Genetic research and testing are increasingly important for understanding and treating pulmonary arterial hypertension. We aimed to explore how attitudes toward genetic research among clinical and research teams impacted the engagement in ge
Externí odkaz:
https://doaj.org/article/35669212093c449ebe904ea6f77589c5
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Genetic research's growing importance in understanding pulmonary arterial hypertension (PAH) and developing effective treatments prompted the RAPID‐PAH study. This study sought feedback from stakeholders who participated in two genomic stu
Externí odkaz:
https://doaj.org/article/3909ff7d528b4c97a6adad6b8534f6d4
Autor:
Sokratis Kariotis, Emmanuel Jammeh, Emilia M. Swietlik, Josephine A. Pickworth, Christopher J. Rhodes, Pablo Otero, John Wharton, James Iremonger, Mark J. Dunning, Divya Pandya, Thomas S. Mascarenhas, Niamh Errington, A. A. Roger Thompson, Casey E. Romanoski, Franz Rischard, Joe G. N. Garcia, Jason X.-J. Yuan, Tae-Hwi Schwantes An, Ankit A. Desai, Gerry Coghlan, Jim Lordan, Paul A. Corris, Luke S. Howard, Robin Condliffe, David G. Kiely, Colin Church, Joanna Pepke-Zaba, Mark Toshner, Stephen Wort, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Allan Lawrie, Dennis Wang, UK National PAH Cohort Study Consortium
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Idiopathic pulmonary arterial hypertension is a rare and fatal disease with a heterogeneous treatment response. Here the authors show that unsupervised machine learning of whole blood transcriptomes from 359 patients with idiopathic pulmonary arteria
Externí odkaz:
https://doaj.org/article/f8e37550b75b47d2a53cbd19d4302aa9
Autor:
Margaret R. MacLean, Divya Pandya, Emilia M. Swietlik, Nina Denver, Kirsty Mair, Nicholas W. Morrell, Stefan Gräf, National Cohort Study for Idiopathic and Heritable Pulmonary Arterial Hypertension Consortium
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for
Externí odkaz:
https://doaj.org/article/dec4cb90876246eabc4530ead367a981
Autor:
Na Zhu, Emilia M. Swietlik, Carrie L. Welch, Michael W. Pauciulo, Jacob J. Hagen, Xueya Zhou, Yicheng Guo, Johannes Karten, Divya Pandya, Tobias Tilly, Katie A. Lutz, Jennifer M. Martin, Carmen M. Treacy, Erika B. Rosenzweig, Usha Krishnan, Anna W. Coleman, Claudia Gonzaga-Juaregui, Allan Lawrie, Richard C. Trembath, Martin R. Wilkins, Regeneron Genetics Center, PAH Biobank Enrolling Centers’ Investigators, NIHR BioResource for Translational Research - Rare Diseases, National Cohort Study of Idiopathic and Heritable PAH, Nicholas W. Morrell, Yufeng Shen, Stefan Gräf, William C. Nichols, Wendy K. Chung
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-18 (2021)
Abstract Background Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to increased pulmonary pressures, right ventricular hypertrophy, and heart failure. PAH can be a
Externí odkaz:
https://doaj.org/article/7d26217cb5954a278edcedd89f0346c6
Autor:
Sokratis Kariotis, Emmanuel Jammeh, Emilia M. Swietlik, Josephine A. Pickworth, Christopher J. Rhodes, Pablo Otero, John Wharton, James Iremonger, Mark J. Dunning, Divya Pandya, Thomas S. Mascarenhas, Niamh Errington, A. A. Roger Thompson, Casey E. Romanoski, Franz Rischard, Joe G. N. Garcia, Jason X.-J. Yuan, Tae-Hwi Schwantes An, Ankit A. Desai, Gerry Coghlan, Jim Lordan, Paul A. Corris, Luke S. Howard, Robin Condliffe, David G. Kiely, Colin Church, Joanna Pepke-Zaba, Mark Toshner, Stephen Wort, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Allan Lawrie, Dennis Wang, UK National PAH Cohort Study Consortium
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/cc1c89b6164a4d8d9937f26685d4f667
Autor:
Stefan Gräf, Matthias Haimel, Marta Bleda, Charaka Hadinnapola, Laura Southgate, Wei Li, Joshua Hodgson, Bin Liu, Richard M. Salmon, Mark Southwood, Rajiv D. Machado, Jennifer M. Martin, Carmen M. Treacy, Katherine Yates, Louise C. Daugherty, Olga Shamardina, Deborah Whitehorn, Simon Holden, Micheala Aldred, Harm J. Bogaard, Colin Church, Gerry Coghlan, Robin Condliffe, Paul A. Corris, Cesare Danesino, Mélanie Eyries, Henning Gall, Stefano Ghio, Hossein-Ardeschir Ghofrani, J. Simon R. Gibbs, Barbara Girerd, Arjan C. Houweling, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Robert V. MacKenzie Ross, Shahin Moledina, David Montani, Michael Newnham, Andrea Olschewski, Horst Olschewski, Andrew J. Peacock, Joanna Pepke-Zaba, Inga Prokopenko, Christopher J. Rhodes, Laura Scelsi, Werner Seeger, Florent Soubrier, Dan F. Stein, Jay Suntharalingam, Emilia M. Swietlik, Mark R. Toshner, David A. van Heel, Anton Vonk Noordegraaf, Quinten Waisfisz, John Wharton, Stephen J. Wort, Willem H. Ouwehand, Nicole Soranzo, Allan Lawrie, Paul D. Upton, Martin R. Wilkins, Richard C. Trembath, Nicholas W. Morrell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Pulmonary arterial hypertension (PAH) is a rare lung disorder characterised by narrowing and obliteration of small pulmonary arteries ultimately leading to right heart failure. Here, the authors sequence whole genomes of over 1000 PAH patients and id
Externí odkaz:
https://doaj.org/article/cb3171b4e79940aa9ab812b5a9ce621a
Autor:
S Ashwin Reddy, Emilia M Swietlik, Lucy Robertson, Alice Michael, Sonja Boyle, Gary Polwarth, Nick J Screaton, Alessandro Ruggiero, Sarah L Nethercott, Dolores Taboada, Karen K Sheares, Charaka Haddinapola, John E Cannon, Katherine Bunclark, David Jenkins, Choo Ng, Mark R Toshner, Joanna Pepke-Zaba
BACKGROUND: We describe baseline characteristics, disease progression and mortality in chronic thromboembolic pulmonary disease patients as a function of mean pulmonary artery pressure (mPAP) according to new and previous definitions of pulmonary hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58534afb732885b35fb8afdc5b7aaa1d
https://www.repository.cam.ac.uk/handle/1810/353664
https://www.repository.cam.ac.uk/handle/1810/353664
Autor:
Na Zhu, Emilia M. Swietlik, Carrie L. Welch, Michael W. Pauciulo, Jacob J. Hagen, Xueya Zhou, Yicheng Guo, Johannes Karten, Divya Pandya, Tobias Tilly, Katie A. Lutz, Jennifer M. Martin, Carmen M. Treacy, Erika B. Rosenzweig, Usha Krishnan, Anna W. Coleman, Claudia Gonzaga-Jauregui, Allan Lawrie, Richard C. Trembath, Martin R. Wilkins, Regeneron Genetics Center, PAH Biobank Enrolling Centers’ Investigators, NIHR BioResource for Translational Research - Rare Diseases, National Cohort Study of Idiopathic and Heritable PAH, Nicholas W. Morrell, Yufeng Shen, Stefan Gräf, William C. Nichols, Wendy K. Chung
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/2f9c2543b76a476ea740d73fa0a70388