Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Emilia Jerman"'
1
Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells
Autor: Gundula Streubel, Ariane Waston, Darrell Andrews, Gerard Cagney, Emilia Jerman, John Crean, Gerard L. Brien, Nayla Munawar, Adrian P. Bracken, Kieran Wynne, Giorgio Oliviero, Benjamin Doyle
Publikováno v: Oliviero, G, Brien, G L, Waston, A, Streubel, G, Jerman, E, Andrews, D, Doyle, B, Munawar, N, Wynne, K, Crean, J, Bracken, A P & Cagney, G 2016, ' Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells ', Molecular & Cellular Proteomics (MCP), vol. 15, no. 11, pp. 3450-3460 . https://doi.org/10.1074/mcp.M116.062240
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene repression.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0f7f7099eeeafcad6d3e019e30ce0f
https://doi.org/10.1074/mcp.m116.062240
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2
Native gel analysis of macromolecular protein complexes in cultured mammalian cells
Autor: Kieran Wynne, Giorgio Olivero, Gundula Streubel, Emilia Jerman, Gerard Cagney, Adrian P. Bracken, Nayla Munawar, Benjamin Doyle
Publikováno v: PROTEOMICS. 15:3603-3612
Native gel electrophoresis enables separation of cellular proteins in their non-denatured state. In experiments aimed at analysing proteins in higher order or multimeric assemblies (i.e. protein complexes) it offers some advantages over rival approac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e110d7564b7f7db908ada3b761f2f0
https://doi.org/10.1002/pmic.201500045
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4
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
Autor: Chris M. Egan, Eiseart J. Dunne, Maike C. Jürgens, Lianhua Piao, Gerard Cagney, Siobhán A. Turner, Neil M. Ferguson, Xiaobing Shi, Kieran Wynne, Gerard L. Brien, Amanda J. Lohan, Adrian P. Bracken, Guillermo Gambero, Krishna M. Sinha, Brendan J. Loftus, Emilia Jerman, David J. O'Connell
Publikováno v: Nature Structural & Molecular Biology. 19:1273-1281
Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional silencing during line
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dea30d27325b15563ed169e344f57ddf
https://doi.org/10.1038/nsmb.2449
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5
Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients
Autor: Fatima Aloraifi, Karsten Hokamp, Adrian P. Bracken, Louise Flanagan, Ashwini Maratha, Gerard L. Brien, Karin Jirström, Amanda J. Lohan, James Geraghty, Cecily Quinn, Brendan J. Loftus, Yue Fan, Emilia Jerman, William M. Gallagher, Marie Fridberg, Martha R. Stampfer, Stephen F. Madden, Eiseart J. Dunne, Fiona Lanigan, James C. Garbe
Publikováno v: The FEBS journal, vol 282, iss 18
Lanigan, F; Brien, GL; Fan, Y; Madden, SF; Jerman, E; Maratha, A; et al.(2015). Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients. FEBS Journal, 282(18), 3455-3473. doi: 10.1111/febs.13354. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/1pk9r3h7
© 2015 FEBS. The majority of women diagnosed with lymph node-negative breast cancer are unnecessarily treated with damaging chemotherapeutics after surgical resection. This highlights the importance of understanding and more accurately predicting pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97eeb0524d6e54ea9ce5b2a3b98144a2
https://escholarship.org/uc/item/1pk9r3h7
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6
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence
Autor: Elisa Fadda, Eric Conway, Aoife McLysaght, Adrian P. Bracken, Emilia Jerman, Scott A. Armstrong, Conor J. Kearney, Alan M. Rice, Andrei V. Krivtsov, David J. O'Connell, Simon S. McDade, Evan Healy, Gerard L. Brien, Darragh O'Donovan, Andrew Flaus, Seamus J. Martin
Publikováno v: Genesdevelopment. 29(21)
Polycomb-like proteins 1–3 (PCL1–3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee123bebcef13312e904991ed6a3ccc
https://pubmed.ncbi.nlm.nih.gov/26494712
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7
Abstract A28: Targeting PCL3/PHF19 as an alternative therapeutic strategy to EZH2 inhibition in PRC2-deregulated cancers
Autor: Gerard L. Brien, Bracken P. Adrian, Emilia Jerman, Matthew Campbell
Publikováno v: Cancer Research. 73:A28-A28
The Polycomb Repressive Complex 2 (PRC2) is emerging as an attractive therapeutic target for the treatment of cancer. Several functional protein domains that are amenable to small-molecule inhibition exist within the complex and the recent developmen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb26fc1af1beabe8efb0f8f48b5b2ded
https://doi.org/10.1158/1538-7445.cec13-a28
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