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pro vyhledávání: '"Emilia Elizabeth Savage"'
Autor:
Emilia Elizabeth Savage, Denise Wootten, Arthur Christopoulos, Patrick Michael Sexton, Sebastian George Barton Furness
Publikováno v:
BioTechniques, Vol 54, Iss 4, Pp 217-221 (2013)
Transient protein-protein interactions form the basis of signal transduction pathways in addition to many other biological processes. One tool for studying these interactions is bioluminescence resonance energ y transfer (BRET). This technique has be
Externí odkaz:
https://doaj.org/article/5bb5bd7b4e1948bbabdb49abc95b1af4
Autor:
Laurence J. Miller, Patrick M. Sexton, John Simms, Kevin J. Smith, Juan Carlos Mobarec, Emilia Elizabeth Savage, Mengjie Liu, Philip E. Thompson, Denise Wootten, Arthur Christopoulos, Rohan Sridhar, Sebastian G.B. Furness, Christopher A. Reynolds, Cassandra Koole, Kavita Pabreja
Publikováno v:
Cell
Summary Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding of the molecular events coupling ligand binding t
Autor:
Patrick M. Sexton, Denise Wootten, Emilia Elizabeth Savage, Laurence J. Miller, Arthur Christopoulos, Cassandra Koole
Publikováno v:
Molecular Endocrinology. 27:1234-1244
The glucagon-like peptide-1 receptor (GLP-1R) controls the physiological responses to the incretin hormone glucagon-like peptide-1 and is a major therapeutic target for the treatment of type 2 diabetes, owing to the broad range of effects that are me
Autor:
Patrick M. Sexton, Denise Wootten, Arthur Christopoulos, Sebastian G.B. Furness, Emilia Elizabeth Savage
Publikováno v:
BioTechniques. 54:217-221
Transient protein-protein interactions form the basis of signal transduction pathways in addition to many other biological processes. One tool for studying these interactions is bioluminescence resonance energ y transfer (BRET). This technique has be
Autor:
Francis S. Willard, Denise Wootten, Kyle W. Sloop, Krister Bokvist, James Ficorilli, Patrick M. Sexton, Jorge Alsina-Fernandez, Thomas B. Farb, Arthur Christopoulos, Emilia Elizabeth Savage, Aaron D. Showalter, Sebastian Gb Furness
Publikováno v:
Molecular Pharmacology. 82:1066-1073
Identifying novel mechanisms to enhance glucagon-like peptide-1 (GLP-1) receptor signaling may enable nascent medicinal chemistry strategies with the aim of developing new orally available therapeutic agents for the treatment of type 2 diabetes melli
Autor:
Cassandra Koole, Patrick M. Sexton, Laurence J. Miller, Arthur Christopoulos, Kavita Pabreja, Sebastian G.B. Furness, Emilia Elizabeth Savage, Denise Wootten
Publikováno v:
Biochemical Society transactions. 41(1)
Type 2 diabetes is a major global health problem and there is ongoing research for new treatments to manage the disease. The GLP-1R (glucagon-like peptide-1 receptor) controls the physiological response to the incretin peptide, GLP-1, and is currentl
Autor:
Patrick M. Sexton, Arthur Christopoulos, Denise Wootten, Emilia Elizabeth Savage, Ana B. Bueno, Francis S. Willard, Kyle W. Sloop
Publikováno v:
Molecular pharmacology. 83(4)
The glucagon-like peptide-1 receptor (GLP-1R) is a major therapeutic target for the treatment of type 2 diabetes due to its role in glucose homeostasis. Despite the availability of peptide-based GLP-1R drugs for treatment of this disease, there is gr
Autor:
Arthur Christopoulos, Kyle W. Sloop, Francis S. Willard, James Ficorilli, Lauren T. May, Denise Wootten, Patrick M. Sexton, Aaron D. Showalter, Emilia Elizabeth Savage, Celine Valant
Publikováno v:
Molecular pharmacology. 82(2)
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and a key drug target class. Recently, allosteric drugs that can co-bind with and modulate the activity of the endogenous ligand(s) for the receptor have become a ma
Autor:
Laurence J. Miller, Patrick M. Sexton, John Simms, Cassandra Koole, Arthur Christopoulos, Denise Wootten, Emilia Elizabeth Savage
The glucagon-like peptide-1 receptor (GLP-1R) is a prototypical family B G protein-coupled receptor that exhibits physiologically important pleiotropic coupling and ligand-dependent signal bias. In our accompanying article (Koole, C., Wootten, D., Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d294991a93bccd222a4e84bd7a4ca1b
https://publications.aston.ac.uk/id/eprint/40235/1/J._Biol._Chem._2012_Koole_3659_73.pdf
https://publications.aston.ac.uk/id/eprint/40235/1/J._Biol._Chem._2012_Koole_3659_73.pdf
Autor:
Patrick M. Sexton, Francis S. Willard, Kyle W. Sloop, Ana B. Bueno, Arthur Christopoulos, Emilia Elizabeth Savage, Denise Wootten
Publikováno v:
Molecular Pharmacology. 84:170-170
In the above article [Wootten, D, Savage EE, Willard FS, Bueno AB, Sloop KW, Christopoulos A, and Sexton PM (2013) Mol Pharmacol 83: [822–834][1]], the structure drawing of TT15 in Fig. 1 is wrong. The structure should be as represented below. The